Angle Plc - ANPCY STOCK NEWS

ANGLE plc has announced breakthrough research from ETH Zurich published in Nature Medicine, featuring their Parsortix system in a Phase 1 clinical trial for metastatic breast cancer treatment. The study used FDA-approved drug digoxin and demonstrated the Parsortix system's critical role in identifying patients with CTC clusters for targeted treatment.

The trial achieved its primary endpoint, showing significant reduction in CTC cluster size in the treatment group. This proof-of-principle study opens possibilities for developing novel drugs preventing metastasis. Professor Aceto's lab has co-founded PAGE Therapeutics to develop compounds effective at disassociating CTC clusters, with Parsortix expected to play a important role in future development.

The research is particularly significant as metastasis accounts for the majority of cancer-related deaths. The Parsortix system's unique ability to capture CTC clusters makes it valuable for developing drugs targeting metastatic spread, potentially improving patient outcomes across all solid tumors.

ANGLE plc (AIM:AGL, OTCQX:ANPCY), a liquid biopsy company, released its trading update for FY2024. Revenue increased 31% to £2.9 million (from £2.2 million in FY23). The company maintains a strong cash position of £10.4 million as of December 31, 2024, with expected R&D tax credits of £1.4 million in Q1 2025 and £0.8 million in Q3 2025, totaling available cash resources of £12.6 million.

The company's annual loss decreased 30% to approximately £14 million (from £20.1 million in FY23), aligning with guidance. Following strategic focus on pharma services and cost reduction, current cash reserves provide runway into 2026. The company expects higher revenue growth in 2025 compared to 2024, with potential for significant increase over time, supported by progressing pharma contracts and new opportunities.

ANGLE plc announced the presentation of an independent study by Weill Cornell Medicine at the San Antonio Breast Cancer Symposium, showcasing a novel Parsortix-based HER2 workflow. The study, involving 16 metastatic breast cancer patients, demonstrated 100% success in isolating CTCs and classifying their HER2 status. The research identified patients with HER2-expressing CTCs who had HER2-negative tissue biopsies, suggesting potential for expanded treatment options.

The workflow enables quantitative and semi-automated assessment of HER2 in CTCs, which is important as HER2 status can change in up to 38% of breast cancer patients. This development could help identify patients eligible for HER2-targeted antibody drug conjugates (ADCs), particularly beneficial for the over 60% of breast cancer patients initially diagnosed as HER2-negative.

ANGLE plc has presented new data at the AACR Special Conference showcasing their Parsortix-based PD-L1 assay for lung cancer monitoring. The assay demonstrated high analytical sensitivity and specificity in identifying different CTC phenotypes and determining PD-L1 status. In a study of metastatic lung cancer patients, CTCs were identified in 91% of cases, with PD-L1 positive CTCs found in 72% of patients with PD-L1 positive tissue biopsies and 27% of those with negative biopsies. The technology enables minimally invasive, longitudinal monitoring of PD-L1 status, potentially advancing personalized treatment approaches.

ANGLE plc presented new data at the AACR Special Conference regarding their development of a Parsortix-based HER2 assay kit in collaboration with BioView. The study, involving 43 metastatic breast cancer patients, showcased a scoring system for HER2 expression in circulating tumor cells (CTCs). The research demonstrated that some initially HER2-negative patients became HER2-positive over time, as detected through CTC analysis. This blood-based test could enable identification of patients who might benefit from HER2-targeted therapies, particularly important since approximately 80% of breast cancer patients are initially categorized as HER2-negative, but their status can change over time.

ANGLE plc presented two posters at the EACR Liquid Biopsies Conference in Lyon, France. The first poster demonstrated the effectiveness of combining Parsortix system with Portrait+ CTC staining kit for detecting and characterizing circulating tumor cells (CTCs). In prostate cancer patients, 64% showed CTC positivity, with 67% of positive samples containing CTC clusters. Notably, 77% of CTC-positive patients had only mesenchymal CTCs.

The second poster showcased enhanced multiplexing capabilities in digital PCR for CTC analysis, demonstrating improved molecular characterization potential using QIAGEN's Qiacuity dPCR system with Parsortix-enriched samples. This advancement allows for simultaneous assessment of multiple genes from a single sample.

ANGLE plc announced research findings on dual analysis of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in non-small cell lung cancer (NSCLC) patients. The study, conducted by the National and Kapodistrian University of Athens, used the Parsortix system to analyze 30 NSCLC patients treated with osimertinib. The research demonstrated that dual analysis of CTC-DNA and ctDNA provides complementary information, enabling better identification of resistance mutations and DNA methylation at disease progression. The study also revealed druggable molecular markers that could inform combined targeted treatment approaches, supporting ANGLE's pharma services strategy.

ANGLE plc (AIM:AGL)(OTCQX:ANPCY) announced the publication of research investigating a panel of prostate cancer gene transcripts in circulating tumor cells (CTCs). The study, conducted by the Medical University of Vienna, used ANGLE's Parsortix system to isolate CTCs from 38 prostate cancer patients. Key findings include:

1. 67% of localized prostate cancer patients were positive for CTC biomarker(s) at baseline.
2. 77% were positive for CTC biomarker(s) after treatment.
3. Strong correlation between specific CTC biomarkers and clinical parameters like tumor grade and stage.

The research supports ANGLE's pharma services business, demonstrating how Parsortix-enriched, CTC-based multi-marker analysis can enhance targeted therapy development and improve patient stratification in clinical trials. This approach could lead to new drug classes requiring a Parsortix-based companion diagnostic for regulatory clearance.

ANGLE plc (AIM:AGL)(OTCQX:ANPCY) announces the 100th peer-reviewed journal article using its Parsortix® system for circulating tumour cell (CTC) analysis. The latest publication, from researchers at Fondazione IRCCS - Istituto Nazionale dei Tumori Di Milano, reports on using the Parsortix system to isolate CTCs from triple negative breast cancer patients for whole genomic sequencing (WGS).

The study used machine learning to identify cancer genes associated with DNA proliferation and repair. The authors conclude that this cost-effective sequencing assay has potential to guide clinical patient management. The 100 publications span a decade of research across 24 cancer types, involving 42 independent institutions in 15 countries.

ANGLE's Chief Scientific Officer, Karen Miller, highlighted that CTC analysis has evolved from simple enumeration to detailed biomarker analysis using advanced techniques. She emphasized the potential of multi-analyte assessment in liquid biopsy as a less invasive and more cost-effective alternative to tissue biopsy.