Alpine Immune Sciences Announces Poster Presentations at AACR Virtual Annual Meeting I

Rhea-AI Summary

Alpine Immune Sciences (NASDAQ:ALPN) announced its participation in the AACR Virtual Annual Meeting I, scheduled for April 10-15, 2021. The company will present two posters: one on the Phase 1 NEON-1 study of ALPN-202, a dual checkpoint inhibitor for advanced malignancies, and another detailing a preclinical study on engineered fusion proteins for anti-tumor immunity. ALPN-202 aims to enhance checkpoint inhibition effectiveness while minimizing toxicities, with promising preclinical efficacy demonstrated.

Positive

• Presentation at a prominent conference (AACR) enhances visibility.
• ALPN-202 shows superior efficacy in preclinical tumor models compared to traditional treatments.
• NEON-1 study is actively enrolling, indicating progress in clinical research.

Negative

• None.

Alpine Immune Sciences, Inc. (NASDAQ:ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for cancer and autoimmune/inflammatory diseases, today announced the planned presentation of two posters at the American Association for Cancer Research (AACR) Virtual Annual Meeting I, taking place April 10-15, 2021. Dr. Mark Voskoboynik of Nucleus Network and The Alfred Hospital in Melbourne, Australia, will be presenting a poster in the Phase 1 Clinical Trials in Progress session on NEON-1, a Phase I study of ALPN-202 in advanced malignancies. Separately, Alpine researchers will present a preclinical poster describing the application of Alpine’s directed evolution platform to the development of fusion proteins capable of tumor antigen-dependent CD28 costimulation, as a distinctive immuno-oncology approach.

Details of the presentations are as follows:

Presentation Title: NEON-1: A first-in-human phase I open-label study of ALPN-202, a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies

• Session Category: Phase I Clinical Trials in Progress
• Session Title: Phase I Clinical Trials in Progress
• Date Poster Available: Saturday, April 10th
• Session Type: E-Poster Session
• Poster Number: CT213

Presentation Title: Engineered variant domain fusion proteins provide checkpoint inhibition and tumor antigen dependent CD28 costimulation resulting in potent anti-tumor immunity

• Session Category: Immunology
• Session Title: Immunomodulatory Agents and Interventions
• Date Poster Available: Saturday, April 10th
• Session Type: E-Poster Session
• Poster Number: 1740

Titles and/or full abstracts are available on the AACR Virtual Annual Meeting website. Posters for both presentations will be available on the Scientific Publications page of Alpine’s website on April 10^th.

About ALPN-202

ALPN-202 is a first-in-class, conditional CD28 costimulator and dual checkpoint inhibitor designed to improve upon the efficacy of combined checkpoint inhibition while limiting significant toxicities. Preclinical studies of ALPN-202 demonstrated superior efficacy in tumor models compared to checkpoint inhibition alone. NEON-1 (NCT04186637), a Phase 1 study of ALPN-202 in patients with advanced malignancies, is currently enrolling.

About Alpine Immune Sciences, Inc.

Alpine Immune Sciences, Inc. is committed to leading a new wave of immune therapeutics. With world-class research and development capabilities, a highly productive scientific platform, and a proven management team, Alpine endeavors to create first- or best-in-class multifunctional immunotherapies via unique protein engineering technologies to improve patients’ lives. Alpine has entered into strategic collaborations with leading global biopharmaceutical companies and has a diverse pipeline of clinical and preclinical candidates in development. For more information, visit www.alpineimmunesciences.com. Follow @AlpineImmuneSci on Twitter and LinkedIn.

“Secreted Immunomodulatory Proteins”, “SIP”, “Transmembrane Immunomodulatory Protein,” “TIP,” “Variant Ig Domain,” “vIgD” and the Alpine logo are registered trademarks or trademarks of Alpine Immune Sciences, Inc. in various jurisdictions.

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FAQ

What is ALPN-202 and its significance for investors?

ALPN-202 is a first-in-class conditional CD28 costimulator and dual checkpoint inhibitor, aimed at improving cancer treatment efficacy while reducing toxicities.

When will the presentations about ALPN-202 take place?

The presentations will occur during the AACR Virtual Annual Meeting I from April 10-15, 2021.

What are the key titles of the posters being presented?

The posters are titled 'NEON-1: A first-in-human phase I open-label study of ALPN-202' and 'Engineered variant domain fusion proteins provide checkpoint inhibition and tumor antigen dependent CD28 costimulation.'

What is the current status of the NEON-1 study?

The NEON-1 study of ALPN-202 is currently enrolling patients with advanced malignancies.