STOCK TITAN

Alpine Immune Sciences, Inc. - ALPN STOCK NEWS

Welcome to our dedicated page for Alpine Immune Sciences news (Ticker: ALPN), a resource for investors and traders seeking the latest updates and insights on Alpine Immune Sciences stock.

Founded in 2015, Alpine Immune Sciences, Inc. (NASDAQ: ALPN) is a leading clinical-stage biotechnology company dedicated to developing innovative protein-based immunotherapies to treat autoimmune and inflammatory diseases. Alpine leverages its unique understanding of immunology, particularly recombinant protein-based immunotherapies, to modify the complexities of the immune synapse for the benefit of patients living with cancer, autoimmune disorders, and other diseases.

Alpine's standout product, povetacicept (ALPN-303), is a dual antagonist of the BAFF and APRIL cytokines. This product is currently in phase 2 development and has demonstrated potential best-in-class efficacy for treating IgA nephropathy (IgAN). IgAN is a serious, progressive kidney disease with no approved therapies that target its underlying cause. Povetacicept has exhibited promising results in reducing proteinuria, stabilizing renal function, and reducing key disease-related biomarkers.

Additionally, Alpine has a robust pipeline, including acazicolcept (ALPN-101), a first-in-class dual inhibitor targeting the CD28 and ICOS T-cell costimulatory pathways. This drug is being investigated for treating systemic lupus erythematosus (SLE) and other autoimmune diseases. Alpine's research and development capabilities are enhanced by strategic collaborations with leading global biopharmaceutical companies, propelling its efforts to create multifunctional immunotherapies that improve patients' lives.

The company has been highly productive in the past year, achieving significant milestones, such as the phase 2 study of acazicolcept in SLE, a pivotal phase 3 trial of povetacicept in IgAN planned for the second half of 2024, and successful financial activities supporting ongoing and future development projects.

Alpine Immune Sciences remains committed to innovation, with ongoing studies in various autoimmune diseases and strategic goals aligning with its mission to lead a new wave of immune therapeutics.

Rhea-AI Summary

Alpine Immune Sciences reported its financial results for the first quarter of 2024, with a cash position of $362.4 million. Vertex Pharmaceuticals will acquire Alpine for $65 per share, expected to close in Q2 2024. Collaboration revenue decreased to $7.0 million, with an increase in research and development expenses to $22.5 million. Net loss for Q1 2024 was $17.9 million.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-- %
Tags
-
Rhea-AI Summary
Alpine Immune Sciences, Inc. (ALPN) shares updated clinical data for povetacicept in IgA nephropathy, showing UPCR reductions of over 60% at 36 weeks, remission, resolution of hematuria, and stable renal function. Successful end of phase 2 meeting with FDA supports advancement to phase 3 study. Key biomarkers Gd-IgA1 and Gd-IgA1/C3 ratios significantly reduced. Monthly dosing well-tolerated with no severe infections.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
36.9%
Tags
-
Rhea-AI Summary
Vertex Pharmaceuticals to Acquire Alpine Immune Sciences for $4.9 Billion: A Strategic Move in Immunotherapy
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-- %
Tags
Rhea-AI Summary
Vertex Pharmaceuticals to Acquire Alpine Immune Sciences for $4.9 Billion in Cash, Focusing on Povetacicept for IgA Nephropathy Treatment
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-- %
Tags
-
Rhea-AI Summary
Alpine Immune Sciences, Inc. (ALPN) to present updated clinical data for povetacicept in IgA nephropathy patients at the World Congress of Nephrology. Investor event scheduled on April 15th.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
1.46%
Tags
conferences clinical trial
-
Rhea-AI Summary
Alpine Immune Sciences presents promising translational data for povetacicept (ALPN-303) at SLEuro 14th European Lupus Meeting. Povetacicept demonstrates superior disease activity reduction in a lupus mouse model compared to WT TACI-Ig or B cell depletion. It shows increased distribution to disease-related organs. A phase 2 study in SLE (DENALI) is planned for 2H 2024.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
3.41%
Tags
none
Rhea-AI Summary
Alpine Immune Sciences, Inc. (ALPN) to participate in H.C. Wainwright 2nd Annual Autoimmune & Inflammatory Disease Virtual Conference. Remy Durand, Chief Business Officer, to join fireside chat. Investor meetings scheduled. Webcasts and replays available on company website.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
3.41%
Tags
conferences
-
Rhea-AI Summary
Alpine Immune Sciences, Inc. reports positive clinical data on povetacicept in IgA nephropathy and systemic lupus erythematosus. The company plans pivotal phase 3 trials for IgAN and phase 2 trials for SLE. Financially, Alpine saw a significant increase in collaboration revenue and a strong cash position, enough to fund operations into 2026.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
12.63%
Tags
-
Rhea-AI Summary
Alpine Immune Sciences, Inc. (ALPN) will release its fourth quarter and full year 2023 financial results on March 18, 2024. The company focuses on developing treatments for autoimmune and inflammatory diseases. A conference call and webcast will be held on the same day.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-2.89%
Tags
conferences earnings
Rhea-AI Summary
Alpine Immune Sciences (ALPN) to participate in two healthcare conferences to discuss IgA Nephropathy and biopharma developments. Live webcasts and investor meetings scheduled.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
3.48%
Tags
conferences

FAQ

What is the current stock price of Alpine Immune Sciences (ALPN)?

The current stock price of Alpine Immune Sciences (ALPN) is $64.97 as of May 17, 2024.

What is the market cap of Alpine Immune Sciences (ALPN)?

The market cap of Alpine Immune Sciences (ALPN) is approximately 4.5B.

What does Alpine Immune Sciences, Inc. specialize in?

Alpine Immune Sciences specializes in developing innovative protein-based immunotherapies for autoimmune and inflammatory diseases.

What is povetacicept (ALPN-303)?

Povetacicept (ALPN-303) is a dual antagonist of the BAFF and APRIL cytokines, showing potential best-in-class efficacy in treating IgA nephropathy (IgAN).

What are the core focus areas of Alpine Immune Sciences?

Alpine focuses on recombinant protein-based immunotherapies to treat cancer, autoimmune disorders, and other diseases.

What recent achievement has Alpine Immune Sciences accomplished?

Alpine recently presented promising phase 2 data for povetacicept in IgA nephropathy and planned a pivotal phase 3 trial for this drug in the second half of 2024.

What is acazicolcept (ALPN-101)?

Acazicolcept (ALPN-101) is a first-in-class dual inhibitor targeting the CD28 and ICOS T-cell costimulatory pathways, being developed for treating systemic lupus erythematosus (SLE) and other autoimmune diseases.

What collaborations has Alpine Immune Sciences engaged in?

Alpine has entered into strategic collaborations with leading global biopharmaceutical companies to enhance its research and development capabilities.

What is the ticker symbol for Alpine Immune Sciences?

Alpine Immune Sciences is traded on NASDAQ under the ticker symbol ALPN.

When was Alpine Immune Sciences founded?

Alpine Immune Sciences was founded in 2015.

What is the mission of Alpine Immune Sciences?

Alpine Immune Sciences aims to lead a new wave of immune therapeutics to improve patients' lives through unique protein engineering technologies.

Where can more information about Alpine Immune Sciences be found?

More information about Alpine Immune Sciences can be found on their website at www.alpineimmunesciences.com.

Alpine Immune Sciences, Inc.

Nasdaq:ALPN

ALPN Rankings

ALPN Stock Data

4.46B
62.73M
4.65%
99.47%
5.93%
Biotechnology
Pharmaceutical Preparations
Link
United States of America
SEATTLE