Agenus Corporate Update and First Quarter 2022 Financial Report
Agenus Inc. (NASDAQ: AGEN) announced significant clinical advancements in its immuno-oncology pipeline. The company is set to initiate Phase 2 trials for botensilimab targeting colorectal, melanoma, and pancreatic cancers, with data updates expected in Q3. AGEN1571 trials will commence following its presentation at AACR, while AGEN2373 is progressing, evidenced by a $5 million milestone payment from Gilead, with potential future payments up to $570 million. Financially, Agenus reported $26 million in revenue for Q1 2022, an increase of $14 million year-over-year, and a net loss of $51 million.
- Phase 2 trials for botensilimab commencing in key cancers.
- Received $5 million milestone payment from Gilead for AGEN2373.
- Net loss of $51 million in Q1 2022, despite revenue growth.
- Cash and short-term investments decreased to $263 million from $307 million.
- Botensilimab data to be presented and Phase 2 trials to launch.
- AGEN1571 (ILT2) clinical trials to commence and data presented at AACR.
- AGEN2373 progressing in the clinic and Gilead milestone payment received.
LEXINGTON, Mass., May 10, 2022 (GLOBE NEWSWIRE) -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of therapeutics designed to activate the immune response to cancers and infections, today provided a corporate update and reported financial results for the first quarter 2022.
“In the current challenging environment for the biotech industry, we are prioritizing our most promising clinical programs, including botensilimab combinations, as well as preclinical programs with the highest potential for engagement from collaborators,” said Garo Armen, PhD, Chairman and Chief Executive Officer of Agenus. “Needless to say, we are also taking decisive steps to contain costs across the board despite our reasonable cash position.”
Botensilimab, Agenus’ innate and adaptive immune stimulator, to advance to Phase 2
- Present updated data from our ongoing development program in the 3rd quarter.
- Phase 2 clinical studies to commence in colorectal, melanoma, and pancreatic cancers.
- All trials designed to demonstrate superiority to other immunotherapies and/or other standards of care.
- In addition, trials are designed to show benefit in cold tumors in combination with chemotherapy.
AGEN1571 clinical trials to commence; preclinical data presented at AACR
- Agenus’ first myeloid-targeting agent.
- Overcomes the suppression of anti-tumor response via the ILT2 pathway which drives resistance to CTLA-4 and PD-1 directed therapies.
- Rationale is further validated by the durable clinical responses achieved in PD-1 resistant cancers with an ILT4 antagonist discovered by Agenus and licensed to Merck.
- Provides advantages in enhanced activation of T, NK and NKT cells and a superior ability to switch myeloid cells to a pro-inflammatory state.
- Phase 1 study to commence.
Milestone payment received from Gilead for the clinical advancement of AGEN2373 targeting CD137
- Another key pathway for antitumor immunity with enhancement of T cell and NK cell proliferation, cytokine secretion, and cellular cytotoxicity.
- Phase 1b combination study with botensilimab ongoing in melanoma patients who have relapsed or are refractory to prior anti-PD-1 therapy.
- Gilead has an exclusive option to license AGEN2373, while Agenus can opt-in for a 50:50 profit share and US co-commercialization rights.
- Agenus received
$5M milestone payment with up to$570 million in future potential option fees and milestones.
First Quarter 2022 Financial Results
We ended our first quarter 2022 with a cash and short-term investment balance of
We recognized revenue of
Net loss for the quarter ended March 31, 2022, was
Cash used in operations for the three months ended March 31, 2022, was
| Select Financial Information | ||||||||
| (in thousands, except per share data) | ||||||||
| (unaudited) | ||||||||
| March 31, 2022 | December 31, 2021 | |||||||
| Cash, cash equivalents and short-term investments | $ | 262,687 | $ | 306,923 | ||||
| Three months ended March 31, | ||||||||
| 2022 | 2021 | |||||||
| Revenues, research and development | $ | 6,740 | $ | 1,571 | ||||
| Revenues, non-cash royalty | 17,634 | 8,484 | ||||||
| Revenues, other | 1,567 | 1,664 | ||||||
| Total Revenue | 25,941 | 11,719 | ||||||
| Research and development expenses | 42,442 | 36,677 | ||||||
| General and administrative expenses | 18,953 | 16,352 | ||||||
| Cost of service revenue | 543 | 1,105 | ||||||
| Other (income) expense | 191 | (2,579 | ) | |||||
| Non-cash interest expense | 14,952 | 15,611 | ||||||
| Non-cash contingent consideration fair value adjustment | (536 | ) | (1,044 | ) | ||||
| Net loss | $ | (50,604 | ) | $ | (54,403 | ) | ||
| Net loss per share attributable to Agenus Inc. common stockholders: | $ | (0.19 | ) | $ | (0.27 | ) | ||
| Cash used in operations | $ | 52,391 | $ | 42,744 | ||||
| Non-cash operating expenses | $ | 21,069 | $ | 20,297 | ||||
Conference Call
Tuesday, May 10, 2022, 8:30am ET
Dial-in numbers: (866) 374-5140 (US Toll-Free) or (404) 400-0571 (US Toll)
Conference PIN: 71044045#
Webcast
A live webcast and replay of the conference call will be accessible from the Events & Presentations page of the Company’s website at https://investor.agenusbio.com/events-and-presentations and via https://edge.media-server.com/mmc/p/5nove2tf.
About Agenus
Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer and infections. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its subsidiary MiNK Therapeutics), adjuvants, and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and Twitter.
Forward-Looking Statements
This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements relating to the use of therapeutic candidates botensilimab, AGEN1571, and AGEN2373, for instance, statements regarding therapeutic benefit and efficacy, mechanism of action (including validation of mechanism of action), potency, durability, and safety profile of the therapeutic candidates, both alone and in combination with each other and/or other agents (e.g., botensilimab in combination with balstilimab); statements relating to future clinical and regulatory development plans for therapeutic candidates alone and in combination with other agents, including botensilimab in combination with balstilimab; statements relating to superiority of our therapeutic candidates over third party therapeutics and therapeutic candidates; statements relating to current or future manufacturing capabilities, manufacturing sustainability and cost-effective manufacturing; statements relating to planned savings or efficiencies; and any other statements containing the words "may," "expects," "anticipates," "will," “establish,” “potential,” “superiority,” and similar expressions are intended to identify forward-looking statements. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Quarterly Report on Form 10-Q or Annual Report on Form 10-K filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.
Contact
Ethan Lovell
339-927-1763
ethan.lovell@agenusbio.com
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