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About ADC Therapeutics SA
ADC Therapeutics SA (NYSE: ADCT) is a leading biotechnology company headquartered in Lausanne, Switzerland, with additional operations in London and New Jersey. The company specializes in the development and commercialization of antibody-drug conjugates (ADCs), a cutting-edge technology that combines the targeting capabilities of antibodies with the potent cell-killing ability of cytotoxic drugs. ADC Therapeutics is dedicated to transforming the treatment paradigm for patients with hematological malignancies and solid tumors, addressing significant unmet medical needs in oncology.
Core Business and Market Position
ADC Therapeutics operates as a commercial-stage biotechnology company, generating revenue primarily through the commercialization of its flagship ADC therapy, ZYNLONTA® (loncastuximab tesirine-lpyl). Approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), ZYNLONTA is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) after two or more lines of systemic therapy. The therapy leverages a proprietary pyrrolobenzodiazepine (PBD) payload to induce tumor cell death, offering a novel approach for patients with difficult-to-treat cancers.
In addition to ZYNLONTA, ADC Therapeutics has a robust pipeline of ADC candidates, including camidanlumab tesirine (ADCT-301), ADCT-602, ADCT-601, and others. These candidates target a range of hematologic and solid tumor indications, underscoring the company’s commitment to advancing innovative therapies in oncology.
Proprietary ADC Technology
The company’s proprietary ADC technology platform is designed to deliver highly potent cytotoxic agents directly to cancer cells while minimizing off-target effects. This targeted approach enhances therapeutic efficacy and reduces systemic toxicity, making it a promising solution for patients with limited treatment options. ADC Therapeutics is also leveraging its exatecan-based platform to explore new applications in solid tumors, further expanding its therapeutic reach.
Pipeline and Clinical Trials
ADC Therapeutics is actively advancing its clinical pipeline through a series of strategically designed trials. Key programs include:
- LOTIS-5: A Phase 3 confirmatory trial evaluating ZYNLONTA in combination with rituximab for r/r DLBCL. This trial aims to expand the label and confirm accelerated approval.
- LOTIS-7: A Phase 1b trial exploring ZYNLONTA in combination with bispecific antibodies like glofitamab in relapsed or refractory B-cell lymphomas.
- Investigator-initiated trials for ZYNLONTA in follicular lymphoma and marginal zone lymphoma, demonstrating promising results in high-risk patient populations.
Competitive Landscape
Operating in the highly competitive field of oncology-focused biotechnology, ADC Therapeutics faces competition from other ADC developers and traditional cancer therapies. However, the company differentiates itself through its proprietary PBD-based ADC technology, strong clinical data, and strategic focus on underserved cancer indications. Its partnerships for global commercialization also enhance its market presence.
Commitment to Innovation and Patient Care
ADC Therapeutics is committed to improving patient outcomes through scientific innovation and strategic execution. By focusing on advancing its clinical pipeline, expanding indications for ZYNLONTA, and leveraging its platform for new therapeutic areas, the company aims to remain at the forefront of ADC technology and oncology treatment.
ADC Therapeutics (NYSE: ADCT) announced positive results from the initial safety run-in of the LOTIS-5 Phase 3 trial, showing a 75% overall response rate and a 40% complete response rate for ZYNLONTA in combination with rituximab for patients with relapsed or refractory diffuse large B-cell lymphoma. The results will be presented at the SOHO 2022 conference in Houston, Texas from September 28-October 1, 2022. Additionally, the company plans to showcase pivotal Phase 2 data for Camidanlumab Tesirine (Cami) during the event.
ADC Therapeutics (NYSE: ADCT) and Swedish Orphan Biovitrum AB announce a positive opinion from the CHMP of the European Medicines Agency, recommending ZYNLONTA® (loncastuximab tesirine) for treating relapsed or refractory diffuse large B-cell lymphoma (DLBCL). This opinion is now under review by the European Commission, with a decision expected in 4Q 2022. Earlier, ADC Therapeutics secured an exclusive licensing deal with Sobi for ZYNLONTA's development in Europe. The favorable CHMP opinion reflects progress towards broader patient access in Europe.
ADC Therapeutics (NYSE: ADCT) announced that
ADC Therapeutics is focused on developing innovative antibody drug conjugates to treat cancer, including ZYNLONTA, which targets relapsed or refractory diffuse large B-cell lymphoma.
ADC Therapeutics (NYSE: ADCT) announced a series of strategic transactions, including a new $175 million senior secured term loan with Owl Rock and Oaktree Capital Management. The company settled $115 million of convertible notes with Deerfield Management, in which Deerfield took equity as part of the settlement. An additional investment of $6.25 million for common shares was made by Owl Rock. The new debt facility, maturing in 2029, helps maintain liquidity into early 2025, supporting the advancement of ADC Therapeutics' cancer treatments.
ADC Therapeutics reported financial results for the second quarter of 2022, highlighting net sales for ZYNLONTA® at $17.3 million, up from $3.8 million year-over-year. The company established a license agreement with Sobi® to enhance global access to ZYNLONTA, extending its cash runway to early 2025. Notable advancements include the initiation of multiple clinical trials, including LOTIS-9 and LOTIS-7. Net loss for the quarter was $64.4 million, showing an improvement compared to the previous year. ADC's focus on increasing product awareness is expected to support ongoing growth.
ADC Therapeutics (NYSE: ADCT) announced a conference call and webcast scheduled for August 9, 2022, at 8:30 a.m. ET to disclose its Q2 2022 financial results and share business updates. The call will provide investors with insights into the company’s performance and operations. ADC Therapeutics specializes in targeted antibody drug conjugates for cancer treatment, including the FDA-approved ZYNLONTA for diffuse large B-cell lymphoma, and ongoing developments in its ADC pipeline.
ADC Therapeutics announced the initiation of a Phase 1b clinical trial for ADCT-601 (mipasetamab uzoptirine), targeting AXL in patients with advanced solid tumors. The trial aims to assess ADCT-601's safety as a standalone and in combination with gemcitabine, particularly in sarcoma, a tumor resistant to current treatments. ADCT-601 has shown a manageable tolerability profile and promising preclinical synergy with gemcitabine. This advancement continues ADC Therapeutics' focus on improving cancer treatment through targeted antibody-drug conjugates.
ADC Therapeutics has initiated the LOTIS-9 Phase 2 clinical trial, targeting unfit and frail patients with previously untreated DLBCL. This trial aims to evaluate the efficacy and tolerability of ZYNLONTA (loncastuximab tesirine-lpyl) combined with rituximab in approximately 80 patients aged 80 and older. The trial follows promising results from the LOTIS-5 Phase 3 trial, addressing a significant medical need in a typically underserved population. The study may pave the way for new treatment options for these patients.
Overland ADCT BioPharma has initiated its Phase 3 LOTIS-5 trial in China, dosing the first patient with ZYNLONTA® combined with rituximab for DLBCL. This follows ZYNLONTA's accelerated FDA approval as a single-agent therapy for relapsed DLBCL. The trial aims to support a supplemental BLA in the U.S. and China for transplant-ineligible patients. This significant milestone reflects the commitment to advancing treatment options for patients with difficult-to-treat DLBCL in China.
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