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About ADC Therapeutics SA
ADC Therapeutics SA (NYSE: ADCT) is a leading biotechnology company headquartered in Lausanne, Switzerland, with additional operations in London and New Jersey. The company specializes in the development and commercialization of antibody-drug conjugates (ADCs), a cutting-edge technology that combines the targeting capabilities of antibodies with the potent cell-killing ability of cytotoxic drugs. ADC Therapeutics is dedicated to transforming the treatment paradigm for patients with hematological malignancies and solid tumors, addressing significant unmet medical needs in oncology.
Core Business and Market Position
ADC Therapeutics operates as a commercial-stage biotechnology company, generating revenue primarily through the commercialization of its flagship ADC therapy, ZYNLONTA® (loncastuximab tesirine-lpyl). Approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), ZYNLONTA is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) after two or more lines of systemic therapy. The therapy leverages a proprietary pyrrolobenzodiazepine (PBD) payload to induce tumor cell death, offering a novel approach for patients with difficult-to-treat cancers.
In addition to ZYNLONTA, ADC Therapeutics has a robust pipeline of ADC candidates, including camidanlumab tesirine (ADCT-301), ADCT-602, ADCT-601, and others. These candidates target a range of hematologic and solid tumor indications, underscoring the company’s commitment to advancing innovative therapies in oncology.
Proprietary ADC Technology
The company’s proprietary ADC technology platform is designed to deliver highly potent cytotoxic agents directly to cancer cells while minimizing off-target effects. This targeted approach enhances therapeutic efficacy and reduces systemic toxicity, making it a promising solution for patients with limited treatment options. ADC Therapeutics is also leveraging its exatecan-based platform to explore new applications in solid tumors, further expanding its therapeutic reach.
Pipeline and Clinical Trials
ADC Therapeutics is actively advancing its clinical pipeline through a series of strategically designed trials. Key programs include:
- LOTIS-5: A Phase 3 confirmatory trial evaluating ZYNLONTA in combination with rituximab for r/r DLBCL. This trial aims to expand the label and confirm accelerated approval.
- LOTIS-7: A Phase 1b trial exploring ZYNLONTA in combination with bispecific antibodies like glofitamab in relapsed or refractory B-cell lymphomas.
- Investigator-initiated trials for ZYNLONTA in follicular lymphoma and marginal zone lymphoma, demonstrating promising results in high-risk patient populations.
Competitive Landscape
Operating in the highly competitive field of oncology-focused biotechnology, ADC Therapeutics faces competition from other ADC developers and traditional cancer therapies. However, the company differentiates itself through its proprietary PBD-based ADC technology, strong clinical data, and strategic focus on underserved cancer indications. Its partnerships for global commercialization also enhance its market presence.
Commitment to Innovation and Patient Care
ADC Therapeutics is committed to improving patient outcomes through scientific innovation and strategic execution. By focusing on advancing its clinical pipeline, expanding indications for ZYNLONTA, and leveraging its platform for new therapeutic areas, the company aims to remain at the forefront of ADC technology and oncology treatment.
ADC Therapeutics (NYSE: ADCT) and Swedish Orphan Biovitrum AB (Sobi) have received conditional marketing authorization from the European Commission for ZYNLONTA (loncastuximab tesirine) to treat relapsed or refractory diffuse large B-cell lymphoma (DLBCL). This approval, based on the LOTIS-2 trial, triggers a
ADC Therapeutics (NYSE: ADCT) has appointed Jose "Pepe" Carmona as Chief Financial Officer (CFO), effective December 19, 2022. He replaces Jenn Creel, who departed for other opportunities. Ameet Mallik, CEO, expressed confidence that Carmona’s extensive experience in the pharmaceutical industry will support corporate growth and enhance shareholder value. Carmona has over 20 years of leadership experience, including previous roles at Rubius Therapeutics, Radius Health, and Novartis. ADC Therapeutics focuses on developing targeted antibody drug conjugates for cancer treatment.
Freenome presented promising research at the ASH Annual Meeting regarding their multiomics platform's ability to identify biomarkers for response to ADC Therapeutics' drug, loncastuximab tesirine (lonca), in treating DLBCL. The collaboration is set to enhance the understanding of treatment efficacy and mechanisms of resistance in patients. Results indicate potential for improved patient-specific predictions using cfDNA profiling combined with clinical data. Both companies emphasize the importance of these findings in guiding treatment strategies for DLBCL patients.
Biocytogen Pharmaceuticals announced an agreement with ADC Therapeutics (NYSE: ADCT) to evaluate Biocytogen's proprietary antibodies against three tumor targets. This agreement allows ADC Therapeutics to license selected antibodies for global development, with Biocytogen retaining all rights beyond ADC development. The agreement includes an upfront payment, option-exercise fees, and milestone payments that may total tens of millions, alongside royalties on net sales. This partnership aims to leverage both companies' expertise in antibody drug conjugates (ADCs) for innovative cancer treatments.
ADC Therapeutics reported strong financial results for Q3 2022, with net sales of $21.3 million for ZYNLONTA, reflecting a 23% increase from Q2 2022. The company has a cash runway extending into early 2025, supported by a $175 million loan and a $55 million upfront payment from a licensing agreement. The LOTIS-5 trial showed favorable initial results, enhancing the outlook for ZYNLONTA. However, the company is pausing significant investments in the Cami program, awaiting further FDA guidance.
ADC Therapeutics (NYSE: ADCT) announced that CEO Ameet Mallik will participate in a fireside chat at the Jefferies London Healthcare Conference on November 15 at 9:45 a.m. GMT. A live webcast will be available on the company's Investors page, with a replay accessible for 30 days. The company specializes in targeted antibody drug conjugates aimed at improving cancer treatment. Its FDA-approved ADC, ZYNLONTA, is used for treating diffuse large B-cell lymphoma, among other ongoing trials.
ADC Therapeutics announced the presentation of multiple abstracts at the 64th American Society of Hematology Annual Meeting in New Orleans from December 10-13, 2022. Highlights include oral presentations on ZYNLONTA (loncastuximab tesirine-lpyl) and ADCT-602, focusing on their efficacy in treating lymphomas. Key presentations involve studies on real-world effectiveness, ongoing Phase 2 trials for Hodgkin lymphoma, and new combinations of ZYNLONTA. Notably, ZYNLONTA has received FDA approval for treating certain B-cell lymphomas, emphasizing its potential in difficult-to-treat cases.
IGM Biosciences and ADC Therapeutics have formed a clinical trial collaboration to examine a combination therapy for relapsed/refractory B cell non-Hodgkin’s lymphoma (NHL). This partnership will evaluate IGM’s imvotamab, a bispecific antibody, alongside ADC’s ZYNLONTA®, an antibody-drug conjugate. The Phase 1 trial is slated to commence in Q1 2023. Previous data indicated a 50% complete response rate for imvotamab at optimal dosing, with manageable safety profiles. Both companies aim to address significant unmet medical needs in lymphoma treatments.
ADC Therapeutics announced the appointments of Kristen Harrington-Smith as Chief Commercial Officer and Peter Graham as Chief Legal Officer, effective November 17, 2022, and November 1, 2022, respectively. Harrington-Smith brings over 20 years of experience in pharmaceuticals, having led important product launches in hematological diseases. Graham, with over 25 years in legal management, aims to support ADC's regulatory and commercial strategies. Both leaders will contribute to maximizing the commercial potential of ZYNLONTA, ADC Therapeutics' CD19-directed ADC.
ADC Therapeutics (NYSE: ADCT) will host a conference call on
The call will be accessible via registration, and details will be available on the ADC Therapeutics investor website. The company specializes in antibody drug conjugates (ADCs) for cancer treatment, with its approved product, ZYNLONTA®, currently aiding patients with relapsed or refractory lymphoma.
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