Agilent Announces New SureSelect Human All Exon V8

Rhea-AI Summary

Agilent Technologies (NYSE: A) has launched the SureSelect Human All Exon V8, enhancing exome sequencing capabilities for genomics research. This new design covers key protein coding regions along with hard-to-capture exons, offering options for routine, clinical, and translational research. The panel spans a 35.1 Mb target region, ensuring outstanding enrichment performance and cost-effective sequencing. Kevin Meldrum highlighted its significance in exome sequencing's growth, further supported by automation on the Bravo platform for efficient laboratory operations.

Positive

• Launch of SureSelect Human All Exon V8 enhances exome sequencing options.
• Comprehensive coverage of protein coding regions and TERT promoter improves research capabilities.
• Efficient probe design leads to improved enrichment performance.
• Integration with Alissa Interpret streamlines variant interpretation in clinical settings.
• Automation with Bravo platform reduces operational costs for labs.

Negative

• None.

Agilent Technologies Inc. (NYSE: A) today announced the release of SureSelect Human All Exon V8 – a new exome design that provides comprehensive content and up-to-date coverage of protein coding regions from RefSeq, CCDS, and GENCODE. It also covers the TERT promoter and hard-to-capture exons that are omitted by other exomes on the market. The new design is available in three options – routine exome sequencing (Exome v8), clinical research sequencing (v8 Clinical Plus), and translational research (v8 UTR Plus) – allowing for content flexibility to meet our customer’s needs.

Powered by machine learning-based probe design and an improved probe-printing process, the SureSelect Human All Exon V8 spans a 35.1 Mb target region of the human genome, with an efficient end-to-end design size of only 41.6 Mb. The panel delivers excellent enrichment performance for more uniform coverage, as well as efficient and cost-effective exome sequencing.

Kevin Meldrum, vice president and general manager for Agilent's Genomics Division, discussed the impact of the release. “The SureSelect exome has been widely adopted in both clinical and translational research, and it has played an important role in shaping the rise of exome sequencing as a routine genomics technique," he said. "The SureSelect Human All Exon V8 provides best-in-class enrichment performance and sequencing efficiency, and it shows our commitment to exceed customer expectations and continue our legacy as the benchmark exome to the genomics community."

This new exome design is already delivering promising results in genetics by supporting virtual analysis of targeted genes important in germline investigations through seamless integration with Alissa Interpret for variant interpretation and reporting. In cancer, exome sequencing is commonly used to identify mutations that contribute to tumor progression, and the sequencing efficiency and coverage achieved with this new design will enable customers to get more out of each exome capture than ever before to identify critical genomic targets. In addition, large-scale manufacturing ensures the panel will provide consistent results for many years, another critical need in clinical research laboratories.

These new Exome designs can be automated on the Bravo automated liquid handling platform for high throughput applications and the Magnis NGS Prep System for complete, walkaway automation. The complete, pushbutton automation provided by the Magnis system will allow laboratories to efficiently deploy exome sequencing while reducing labor and operational expenses.

About Agilent Technologies

Agilent is a leader in life sciences, diagnostics, and applied chemical markets, delivering innovative technology solutions that provide trusted answers to researchers’ most challenging scientific questions. The company generated revenue of $5.34 billion in fiscal year 2020 and employs 16,400 people worldwide. Information about Agilent is available at www.agilent.com. To receive the latest Agilent news, please subscribe to the Agilent Newsroom. Follow Agilent on LinkedIn, Twitter, and Facebook.

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FAQ

What is the SureSelect Human All Exon V8 by Agilent?

The SureSelect Human All Exon V8 is a new exome design that provides comprehensive coverage of protein coding regions, enhancing sequencing capabilities.

How does the new exome design impact genomics research?

It improves enrichment performance and sequencing efficiency, allowing for better identification of critical genomic targets.

What manufacturing advantages does the SureSelect V8 offer?

The design ensures consistent results through large-scale manufacturing, meeting the needs of clinical research laboratories.

Is automation supported for the SureSelect Human All Exon V8?

Yes, it can be automated using the Bravo platform for high-throughput applications.

What are the options available with the SureSelect Human All Exon V8?

The options include routine exome sequencing, clinical research sequencing, and translational research.