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Pliant Therapeutics announced positive topline data from a 12-week Phase 2a clinical trial of bexotegrast (PLN-74809) in patients with idiopathic pulmonary fibrosis (IPF). The study showed that bexotegrast 160 mg led to a reduction in total lung collagen compared to an increase in the placebo group, suggesting potential reversal of fibrosis. Improvements in forced vital capacity (FVC) and reduced cough severity were observed in bexotegrast-treated patients at all timepoints. The drug was well tolerated with no serious adverse events or discontinuations. The trial involved 10 patients, with 7 receiving bexotegrast and 3 on placebo. PET imaging was used to measure changes in lung collagen levels. The primary endpoint was the change in standardized uptake value (SUV) of a PET ligand that binds to type 1 collagen. Bexotegrast-treated patients showed a reduction in SUV, indicating a decrease in lung collagen. Additionally, improvements in fibrosis biomarkers, FVCpp, and patient-reported cough severity were noted.
Pliant Therapeutics, Inc. (PLRX) announces two poster presentations at the EASL International Liver Congress in Milan, Italy. The presentations focus on the updated safety and efficacy analysis of the INTEGRIS-PSC Phase 2a trial and the TGF-beta inhibition in human liver explant tissue with biliary fibrosis. The company continues to lead in the discovery of novel therapeutics for fibrotic diseases.
Pliant Therapeutics, a leader in fibrotic disease therapeutics, reported positive safety and efficacy data from Phase 2a trials. They accelerated the BEACON-IPF Phase 2b trial and received regulatory clearance for the PLN-101325 muscular dystrophy program. Financially, they reported a net loss of $47.0 million, with $483.9 million in cash and investments as of March 31, 2024.
Pliant Therapeutics, a clinical-stage biotechnology company focusing on fibrotic diseases, will participate in investor events in May 2024. The events include discussions with key company executives, offering insights into the company's progress and future plans.