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Zymeworks Inc. (Nasdaq: ZYME) is a global biotechnology company committed to the discovery, development, and commercialization of novel, multifunctional biotherapeutics. The company's mission is to make a meaningful difference for people impacted by difficult-to-treat cancers and other serious diseases.
Zymeworks specializes in developing best-in-class bi-specific antibodies and antibody-drug conjugates (ADCs) to treat oncology, autoimmunity, and inflammatory diseases. Their proprietary platforms, including Azymetric™, Albucore™, and ZymeLink™, enable the creation of highly potent bi-specific antibodies and multivalent protein therapeutics targeting a range of indications.
The company's leading therapeutic candidate, zanidatamab, is a novel HER2-targeted bispecific antibody currently in multiple Phase 1, Phase 2, and pivotal clinical trials globally. Zanidatamab is being developed as a targeted treatment for patients with HER2-expressing cancers. Recent milestones include the acceptance of a Biologics License Application (BLA) by the FDA and China's National Medical Products Administration (NMPA) for second-line treatment of HER2-positive biliary tract cancers (BTC).
Zymeworks is also advancing a deep preclinical pipeline, including candidates like zanidatamab zovodotin (ZW49) and new investigational drugs ZW171 and ZW191, with plans for multiple IND filings in 2024 and 2025. The company is financially robust, with a cash runway extending into the second half of 2027, bolstered by strategic partnerships with BeiGene and Jazz Pharmaceuticals, among others.
The company's complementary therapeutic platforms and fully integrated drug development engine enable precise engineering of differentiated product candidates, offering potential best-in-class treatments for various challenging diseases. For more information, visit www.zymeworks.com.
Zymeworks presented new preclinical data for two antibody-drug conjugate (ADC) candidates, ZW220 and ZW251, at the EORTC-NCI-AACR Conference. ZW220, targeting NaPi2b, shows potential for treating NSCLC, ovarian, and uterine cancers, with high tolerability in animal studies. ZW251, targeting glypican-3, demonstrates promise for hepatocellular carcinoma treatment. Both candidates incorporate Zymeworks' proprietary payload ZD06519. The company plans IND submissions for ZW220 in first half 2025 and ZW251 in second half 2025. The preclinical data suggests potential improvements over current standards of care, with favorable toxicology profiles and efficacy in various cancer models.
Zymeworks Inc. (Nasdaq: ZYME) has announced the dosing of the first patient in a Phase 1 clinical trial (NCT06523803) for ZW171, an investigational therapy targeting mesothelin (MSLN)-expressing cancers. The global study aims to evaluate the safety and tolerability of ZW171 in treating advanced ovarian cancer, non-small cell lung cancer (NSCLC), and other MSLN-expressing cancers.
The trial is designed as a two-part, open-label multi-center study, expected to enroll approximately 160 adult patients. Part 1 will focus on dose escalation in ovarian cancer and NSCLC patients, while Part 2 will involve dose expansion in three cohorts. The study will be conducted at sites in the United States, Europe, and the Asia-Pacific region.
Preclinical studies have shown ZW171's potential for potent, preferential killing of MSLN-overexpressing cells and stimulation of MSLN-dependent T cell activation, with potentially favorable tolerability.
Zymeworks Inc. (Nasdaq: ZYME), a clinical-stage biotechnology company, has announced it will report its third quarter 2024 financial results after market close on October 31, 2024. Following this, the company will host a conference call and webcast at 4:30 pm Eastern Time on the same day to discuss the financial results and provide a corporate update.
Zymeworks develops a diverse pipeline of novel, multifunctional biotherapeutics aimed at improving the standard of care for difficult-to-treat diseases. The event will be webcast live, and both dial-in details and webcast replays will be available on the company's investor relations website at https://ir.zymeworks.com/events-and-presentations.
Zymeworks Inc. (Nasdaq: ZYME) announced two presentations at the upcoming EORTC-NCI-AACR Conference in Barcelona, showcasing preclinical data for their antibody-drug conjugate (ADC) candidates ZW220 and ZW251. ZW220, targeting NaPi2b, demonstrated promising activity in non-small cell lung, ovarian, and uterine cancer models. ZW251, targeting glypican-3, showed compelling results in hepatocellular carcinoma models. Both candidates utilize Zymeworks' proprietary payload, ZD06519.
Chief Scientific Officer Paul Moore expressed excitement about the progress of these next-generation ADC programs, which are on track for IND filings in 2025. This follows the recent advancement of ZW171 and ZW191, currently in Phase 1 studies. The presentations highlight Zymeworks' ongoing development of novel biotherapeutics for difficult-to-treat cancers and other diseases.
Zymeworks Inc. (Nasdaq: ZYME) has reported an equity inducement award to Ms. Leone Patterson, their new Executive Vice President and Chief Business and Financial Officer. The award, granted under Nasdaq Stock Market Rule 5635(c), consists of a stock option to purchase 360,000 shares of the company's common stock. The option has an exercise price of $11.73 per share, equal to the closing price on August 30, 2024, and a maximum term of 10 years.
The option will vest over four years, with 25% vesting on the one-year anniversary of Ms. Patterson's start date (September 1, 2024), and the remaining 75% vesting monthly over the following three years. In the event of a change of control followed by termination without cause within 12 months, all unvested shares will fully vest.
Zymeworks Inc. (Nasdaq: ZYME), a clinical-stage biotechnology company, has announced its participation in four upcoming investor conferences in September 2024. These events include:
- Wells Fargo Healthcare Conference on September 4 in Boston, MA
- Morgan Stanley 22nd Annual Global Healthcare Conference on September 5 in New York, NY
- H.C. Wainwright 26th Annual Global Investment Conference on September 10 in New York, NY
- 2024 Cantor Global Healthcare Conference on September 18 in New York, NY
At each conference, Zymeworks' management will engage in one-on-one meetings and participate in fireside chats. The company, which focuses on developing novel, multifunctional biotherapeutics for difficult-to-treat diseases, aims to improve its visibility among investors and showcase its progress in the biotechnology sector.
Augurex Life Sciences Corp., a leader in early autoimmune disease diagnosis, has appointed Neil Klompas as President and CEO, succeeding co-founder Dr. Norma Biln. Dr. Biln will transition to global head of product research and development while remaining Board Chair. Klompas, a veteran life sciences executive with over 30 years of experience, most recently served as President and COO of Zymeworks (NASDAQ: ZYME).
Augurex's key products include JOINTstat®, a diagnostic for autoimmune arthritic diseases, and the upcoming SPINEstat®, a potential first-in-class diagnostic for Ankylosing Spondylitis. Klompas aims to lead Augurex into its next phase of commercial growth, focusing on delivering value to patients and shareholders.
Zymeworks Inc. (Nasdaq: ZYME) has announced a $60 million Share Repurchase Program authorized by its Board of Directors. The company plans to initiate the program with $30 million in initial repurchases, starting promptly and continuing through the second half of 2024. The remaining $30 million will be reserved for future repurchases, allowing flexibility to adapt to market conditions and growth opportunities.
Kenneth Galbraith, Chair and CEO, stated that this decision reflects confidence in the company's future outlook, pipeline strength, and commitment to stockholder value. The program will be funded through Zymeworks' strong balance sheet and may be executed through open market transactions or other means, in accordance with SEC regulations. The timing, number of shares, and prices will depend on various factors, and the program can be suspended or discontinued at any time.
Zymeworks Inc. (Nasdaq: ZYME) reported its Q2 2024 financial results and provided a corporate update. Key highlights include:
- $395.9 million in cash resources as of June 30, 2024, with projected runway into 2H 2027
- Priority Review granted for zanidatamab BLA in HER2-positive biliary tract cancers (BTC) with target action date of November 29, 2024
- EMA validated the MAA for zanidatamab in 2L BTC
- $8 million milestone payment received from BeiGene for zanidatamab BLA acceptance in China
- FDA clearance for ZW191 and ZW171 INDs, with first-in-human studies planned for 2H 2024
- Appointment of Leone Patterson as EVP, Chief Business Officer and CFO
Financial results: $29.3 million revenue for H1 2024, net loss of $69.3 million, decreased from $75.5 million in H1 2023.
Zymeworks Inc. (Nasdaq: ZYME), a clinical-stage biotechnology company, has announced its participation in two upcoming investor conferences. The company, which focuses on developing novel, multifunctional biotherapeutics for difficult-to-treat diseases, will be present at:
1. BTIG Virtual Biotechnology Conference on August 6, where management will engage in virtual one-on-one meetings and a fireside chat at 4:00 pm ET.
2. Wedbush PacGrow Healthcare Conference on August 13-14 in New York, NY. Here, Zymeworks will participate in a panel discussion titled 'ADCs and Old Lace: Antibody Drug Conjugates' on August 14 from 8:45 – 9:25 am ET, as well as one-on-one meetings throughout the event.
These conferences provide Zymeworks with opportunities to showcase their progress and engage with investors in the biotechnology sector.
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