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ZyVersa Therapeutics, Inc. - ZVSA STOCK NEWS

Welcome to our dedicated page for ZyVersa Therapeutics news (Ticker: ZVSA), a resource for investors and traders seeking the latest updates and insights on ZyVersa Therapeutics stock.

ZyVersa Therapeutics, Inc. (Nasdaq: ZVSA) is a clinical-stage specialty biopharmaceutical company committed to developing first-in-class drugs for patients with renal and inflammatory diseases who have significant unmet medical needs. Leveraging advanced proprietary technologies, ZyVersa is focused on creating therapeutic solutions that address these critical health challenges.

ZyVersa's impressive pipeline features two main drug development platforms. The Cholesterol Efflux Mediator™ VAR 200 (2-hydroxypropyl-beta-cyclodextrin) is an injectable drug in clinical development for treating kidney diseases caused by lipid accumulation. Clinical trials for VAR 200 have shown promising results in animal models of diabetic kidney disease, focal segmental glomerulosclerosis (FSGS), and Alport syndrome (AS). The Phase 2a clinical trial protocol for diabetic kidney disease has recently received IRB approval, marking a significant milestone in the drug's development.

The second platform is the Inflammasome ASC Inhibitor IC 100, a novel humanized IgG4 monoclonal antibody. IC 100 inhibits the inflammasome adaptor protein ASC, which plays a crucial role in the body's inflammatory response. The drug is in preclinical development for treating various inflammatory conditions, including neurological diseases like Alzheimer's, multiple sclerosis, and traumatic brain injury. Recent research has highlighted IC 100's potential in addressing obesity-related inflammation and metabolic complications, further expanding its therapeutic scope.

Under the leadership of an experienced team with over 15 years of success in the biopharmaceutical industry, ZyVersa continues to advance its drug candidates towards clinical trials. The company's strategic partnerships and collaborations with notable research institutions like the University of Miami Miller School of Medicine further bolster its research and development efforts.

Financially, ZyVersa is navigating the challenges of a clinical-stage biopharmaceutical company. While the company reported a net loss of $98.3 million for the year ending December 31, 2023, it continues to secure funding through public and private equity, grants, and collaborations. Recent financial updates indicate a net loss improvement for Q1 2024, with operating expenses managed efficiently to support ongoing and future clinical trials.

For more detailed information, visit the ZyVersa Therapeutics website and stay updated with their latest news and developments.

Rhea-AI Summary
ZyVersa Therapeutics, Inc. has published a study in Molecular Neurobiology demonstrating the neuroprotective effects of NLRP3 inflammasome inhibition in a mouse model of multiple sclerosis (MS). The study showed significant decreases in neuronal damage and demyelination with NLRP3 inhibition. MS affects around 2.1 million people worldwide and is characterized by neuron damage in the central nervous system, leading to physical and cognitive disability. ZyVersa is developing Inflammasome ASC Inhibitor IC 100, which aims to attenuate damaging inflammation by inhibiting the formation of inflammasomes and their associated ASC specks.
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Obesity exacerbates scarring of the heart's muscular tissue through inflammasome ASC recruitment to the heart's mitochondria, leading to damaging inflammation. ZyVersa Therapeutics announces a publication in Diabetes demonstrating the role of ASC in obesity-induced myocardial fibrosis. Inhibition of NLRP3 activation or removal of IL-1β and IL-18 abated adverse effects on cardiac fibrosis and function in mice.
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Chronic kidney disease worsens with age due to NLRP3 inflammasome signaling in the kidneys' filtration system, according to a study by ZyVersa Therapeutics.
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ZyVersa Therapeutics announces publication of a review paper highlighting the role of kidney cholesterol and lipid accumulation in chronic kidney disease (CKD) development and progression.
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ZyVersa Therapeutics publishes scientific paper on the role of inflammation in brain and heart health
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ZyVersa Therapeutics announces that Stephen C. Glover will participate in a panel and serve as a judge at the BioFlorida Conference. ZyVersa is developing drugs for the treatment of renal and inflammatory diseases.
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ZyVersa highlights how chronic kidney disease triggers inflammation in the heart, leading to atrial fibrillation. They are developing Inflammasome ASC Inhibitor IC 100 to attenuate IL-1β propagation and control inflammation. The research supports the importance of inhibiting inflammasomes to reduce damaging inflammation.
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ZyVersa Therapeutics provides corporate update and reports Q2 2023 financial results
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ZyVersa Therapeutics, Inc. announces the pricing of a public offering of common stock and warrants, with expected gross proceeds of approximately $2.1 million. The offering is expected to close on July 26, 2023.
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FAQ

What is the current stock price of ZyVersa Therapeutics (ZVSA)?

The current stock price of ZyVersa Therapeutics (ZVSA) is $1.14 as of December 20, 2024.

What is the market cap of ZyVersa Therapeutics (ZVSA)?

The market cap of ZyVersa Therapeutics (ZVSA) is approximately 3.0M.

What is ZyVersa Therapeutics, Inc.?

ZyVersa Therapeutics, Inc. (Nasdaq: ZVSA) is a clinical-stage biopharmaceutical company developing first-in-class drugs for renal and inflammatory diseases.

What are ZyVersa's main drug platforms?

ZyVersa's main drug platforms are Cholesterol Efflux Mediator™ VAR 200 for kidney diseases and Inflammasome ASC Inhibitor IC 100 for inflammatory conditions.

What is the status of the VAR 200 clinical trials?

VAR 200 is in Phase 2a clinical trials for diabetic kidney disease, with IRB approval recently granted and trials set to begin in the first half of 2024.

What conditions does IC 100 target?

IC 100 targets various inflammatory conditions, including neurological diseases like Alzheimer's, multiple sclerosis, and traumatic brain injury, as well as obesity-related inflammation.

Who are ZyVersa's research partners?

ZyVersa collaborates with institutions like the University of Miami Miller School of Medicine to advance its research and development efforts.

What recent financial updates has ZyVersa reported?

For Q1 2024, ZyVersa reported a net loss improvement and efficient management of operating expenses to support ongoing and future clinical trials.

What technologies does ZyVersa utilize in its drug development?

ZyVersa leverages advanced proprietary technologies, including Cholesterol Efflux Mediator™ and Inflammasome ASC Inhibitor platforms, to develop its drugs.

How does IC 100 function?

IC 100 is a monoclonal antibody that inhibits the inflammasome adaptor protein ASC, attenuating inflammatory responses by blocking activation of IL-1β.

What is the significance of the recent IRB approval for VAR 200?

IRB approval for the Phase 2a clinical trial of VAR 200 in diabetic kidney disease is a key milestone, indicating readiness to begin human trials.

Where can I find more information about ZyVersa?

For more information, visit ZyVersa's official website at www.zyversa.com.

ZyVersa Therapeutics, Inc.

Nasdaq:ZVSA

ZVSA Rankings

ZVSA Stock Data

2.98M
2.50M
0.61%
4.47%
4.23%
Biotechnology
Pharmaceutical Preparations
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United States of America
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