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Zentalis Pharmaceuticals, Inc. (NASDAQ: ZNTL) is a clinical-stage biopharmaceutical company dedicated to discovering and developing innovative small molecule therapeutics that target fundamental biological pathways in cancer. Utilizing its proprietary Integrated Discovery Engine, Zentalis aims to identify unique targets and develop novel, potentially best-in-class new chemical entities (NCEs) with differentiated product profiles.
The company's robust pipeline is highlighted by two lead product candidates: ZN-c5 and ZN-c3. ZN-c5 is being developed for the treatment of advanced estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer, while ZN-c3 targets advanced solid tumors and ovarian cancer. Zentalis is also developing azenosertib (ZN-c3), a WEE1 inhibitor, as a monotherapy and in combination with other agents to address multiple tumor types.
Recently, Zentalis announced plans to use the net proceeds from its latest offering to fund ongoing and planned clinical trials, as well as for working capital and other general corporate purposes. The company’s financial strategy is designed to support its operational expenses and capital expenditure requirements through 2026.
The company’s latest financial disclosures highlighted strong clinical data for azenosertib, showing an objective response rate of 36.8% in ovarian cancer and uterine serous carcinoma patients. Azenosertib, currently in multiple clinical trials, demonstrated encouraging efficacy both as a monotherapy and in combination with chemotherapy.
Headquartered in New York and San Diego, Zentalis is collaborating with top financial institutions like Morgan Stanley, Jefferies, and Guggenheim Securities to drive its growth. The company's strong cash position is bolstered by its recent offerings and ongoing support from financial advisors.
Continuing to advance its clinical strategies, Zentalis is focused on its fast-to-market approach for azenosertib, aiming to submit its first NDA in gynecologic malignancies by 2026. Furthermore, Zentalis is leveraging its expertise in cancer biology and medicinal chemistry to explore the potential of protein degraders and other innovative treatment modalities.
Stay updated on Zentalis Pharmaceuticals’ latest developments by visiting their official website or following them on social media platforms such as Twitter and LinkedIn.
Zentalis Pharmaceuticals (Nasdaq: ZNTL) announced that CEO Anthony Sun will speak at two virtual investor conferences on September 17, 2020. The events are the Morgan Stanley 18th Annual Global Healthcare Conference at 8:45 a.m. ET and the Cantor Fitzgerald Virtual Global Healthcare Conference at 10:00 a.m. ET. Both presentations will be webcast live on Zentalis' website. The company focuses on developing small molecule therapeutics targeting cancer pathways, with a promising pipeline including ZN-c5 for breast cancer and other inhibitors.
On August 13, 2020, Zentalis Pharmaceuticals (ZNTL) announced key financial results for Q2 2020, highlighted by a successful IPO raising ~$190 million and a follow-on offering generating ~$144.4 million. The company also completed a $20 million Series A financing for its joint venture, Zentera Therapeutics. Strategic collaborations with Eli Lilly and Tavros Therapeutics were established to enhance their oncology pipeline. Despite a net loss of $27.3 million, Zentalis maintains a strong cash position of $233.2 million, which is expected to fund operations into 2023.
Zentalis Pharmaceuticals (Nasdaq: ZNTL) has announced a public offering of 4,125,000 shares of common stock at $35.00 per share, aiming for total gross proceeds of approximately $144.4 million. The offering is set to close on August 3, 2020, subject to customary conditions. Additionally, underwriters have a 30-day option to purchase up to 618,750 extra shares.
The effective registration statement was filed with the U.S. SEC on July 29, 2020. Zentalis focuses on developing small molecule therapeutics targeting cancer.
Zentalis Pharmaceuticals, Inc. (Nasdaq: ZNTL) announced a public offering of 3,750,000 shares of its common stock, with an additional 562,500 shares available for underwriters. The offering, managed by Morgan Stanley, Jefferies, SVB Leerink, and Guggenheim Securities, aims to provide funding for the company's oncology product development. While the registration statement has been filed with the SEC, it is not yet effective. Proceeds from the sale will potentially support their ongoing research and development in cancer therapeutics.
Zentalis Pharmaceuticals, Inc. (Nasdaq: ZNTL) announced a clinical collaboration with Eli Lilly to evaluate ZN-c5, a selective estrogen receptor degrader, in combination with Lilly's Verzenio for treating ER+/HER2- advanced breast cancer. This study aims to assess the potential of ZN-c5 alongside a CDK4 and 6 inhibitor, building upon existing therapies. Zentalis will conduct the trial while retaining ownership of ZN-c5, with Lilly providing Verzenio doses. ZN-c5 is currently in a Phase 1/2 trial as a monotherapy and with palbociclib, another collaboration with Pfizer.
Zentalis Pharmaceuticals (Nasdaq: ZNTL) has appointed Dr. Kimberly Blackwell to its Board of Directors. A seasoned breast cancer researcher, Dr. Blackwell brings over 20 years of experience in the biopharmaceutical sector. Her previous roles include Chief Medical Officer at Tempus and Vice President of Early Phase Oncology at Eli Lilly. Dr. Blackwell's expertise in oncology will be crucial for advancing Zentalis's oncology pipeline. The company is focused on developing small molecule therapeutics targeting cancer pathways, including promising candidates like ZN-c5 and ZN-c3.
Zentalis Pharmaceuticals (Nasdaq: ZNTL) announced the presentation of preclinical data on ZN-c5 at the AACR Virtual Annual Meeting II from June 22-24, 2020. ZN-c5, an oral selective estrogen receptor degrader, showed anti-tumor activity in breast cancer models and favorable oral bioavailability across species. Currently under evaluation in a Phase 1/2 trial for ER+/HER2- advanced breast cancer, ZN-c5 may pave the way for improved treatment options in oncology.
Zentalis Pharmaceuticals (Nasdaq: ZNTL) announced that its CEO, Anthony Sun, MD, will participate in a fireside chat at the Jefferies Virtual Healthcare Conference on June 4, 2020, at 1:30 p.m. ET. A live webcast will be available on the company’s website, with an archived version accessible afterwards.
Zentalis focuses on developing novel small molecule therapeutics targeting cancer pathways, including its lead program, ZN-c5, an oral selective estrogen receptor degrader for breast cancer. For more information, visit www.zentalis.com.
Zentalis Pharmaceuticals (Nasdaq: ZNTL) announced a strategic collaboration with Tavros Therapeutics to enhance its oncology pipeline. This partnership aims to utilize Tavros' functional genomic discovery platform to identify new targeted small molecule drug candidates. Both CEOs expressed optimism about leveraging their technologies to produce safer and more effective cancer therapies. The agreement grants each company rights to any new products developed through this collaboration. This partnership could significantly advance Zentalis' development of innovative treatments for cancer patients.
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