XORTX Therapeutics Inc. - XRTX STOCK NEWS

XORTX Therapeutics Inc. (NASDAQ: XRTX) announced the acceptance of an abstract for presentation at the American Society of Nephrology's Kidney Week 2024. The abstract, titled 'Xanthine oxidase in rats, mice and humans with polycystic kidney disease', focuses on the role of xanthine oxidase (XO) in polycystic kidney disease (PKD). The study, conducted at the University of Colorado and sponsored by XORTX, aimed to understand serum xanthine oxidase activity (XOa) in PKD and its relation to total kidney volume and glomerular filtration rate (GFR) decline.

The research investigated XO activity in PCK1 rats, PKD1RC/RC mice, and 34 patients from the HALT-PKD Clinical study. Results provide insights into how aberrant purine metabolism in PKD tissue may contribute to circulating uric acid levels, kidney expansion rate, and GFR decline. This study builds on previous findings suggesting XO overexpression in PKD kidney tissue. XORTX plans to provide a detailed update on the study results in early November.

XORTX Therapeutics, a late-stage clinical pharmaceutical company focused on treating progressive kidney disease, announces its participation in the BIO International Convention 2024 from June 3-6 at the San Diego Convention Center. CEO Dr. Allen Davidoff will present an overview of the company's progress and future plans on June 4 at 3:30 pm in Theater 1. The event aims to foster outreach to pharmaceutical partners and industry contacts, with over 25 meetings scheduled. One-on-one meetings with Dr. Davidoff can be arranged through the BIO International 2024 meeting platform.

XORTX Therapeutics announced the repricing of warrants issued in October 2021, receiving approval from the TSX Venture Exchange to amend the terms. The repricing affects 101,111 warrants post a 9:1 consolidation, lowering the exercise price from USD $42.93 to USD $5.00. If the company's stock price exceeds USD $6.50 for ten consecutive trading days, warrant holders must exercise their options within 30 days or face expiration.

XORTX Therapeutics Inc. announces the amendment of 1,024,099 outstanding common share purchase warrants by changing the exercise price to USD $5.00 per share. The TSX Venture Exchange approved the amendments related to Private Placements from 2021 to 2022. Additionally, a new Warrant Acceleration Provision was introduced.

XORTX Therapeutics Inc. announces the publication of a research paper in the American Journal of Physiology-Renal Physiology focusing on the effects of increasing serum uric acid on Autosomal Dominant Polycystic Kidney Disease (ADPKD). The study reveals that elevated uric acid levels can significantly impact cyst growth and kidney size in ADPKD, potentially accelerating disease progression. The research also highlights the potential benefits of XORTX's XORLO™ in attenuating these effects, offering new insights into the treatment of ADPKD.

XORTX Therapeutics Inc. welcomes Abigail Jenkins, a biotech industry veteran, to its Board of Directors. Ms. Jenkins brings over 20 years of leadership experience in delivering life-enhancing therapies. She has held key positions at various biopharmaceutical companies and holds a Master of Science in biotechnology. XORTX has granted 8,000 stock options to Ms. Jenkins.

XORTX Therapeutics Inc. announces participation in investor conferences, engagement of LHA Investor Relations for services.

XORTX Therapeutics Inc. announces the addition of Dr. Ronald Perrone to its Clinical Advisory Board, enhancing the expertise in treating autosomal dominant polycystic kidney disease (ADPKD). Dr. Perrone's vast experience in nephrology and clinical research will benefit the company's advanced clinical program, particularly the XRX-OXY-201 registration trial.

XORTX Therapeutics Inc. reports significant progress in 2023, achieving key milestones in the development of therapies for kidney diseases. The Company received U.S. Orphan Drug Designation for the XRx-008 program for ADPKD, aligning endpoints for accelerated approval. XORTX made advancements in chemistry, manufacturing, and clinical studies, aiming to conduct a registration clinical trial in 2024. Notable achievements include FDA and EMA regulatory submissions, patent advancements, and organizational enhancements. The independent commercial assessment forecasts potential worldwide peak sales exceeding $1B annually for the XRx-008 program.