XPhyto Completes Rotigotine Transdermal Patch Optimization and Comparative Skin Absorption Study

Rhea-AI Summary

XPhyto Therapeutics Corp. has completed the optimization of its Rotigotine transdermal patch formulation intended for Parkinson's disease treatment. The final comparative study using human skin cadaver samples has also been concluded, with results expected shortly. The global market for Rotigotine patches is projected to surpass US$766 million by 2030, with significant growth opportunities within the transdermal skin patch market, valued at US$20 billion by 2028. XPhyto aims to leverage its proprietary technology for additional pharmaceutical developments.

Positive

• Completion of Rotigotine TDS formulation optimization.
• Final comparative study on skin absorption completed, with results pending.
• Large market potential for Rotigotine patches, expected to surpass US$766 million by 2030.
• Opportunities for expansion in the US$20 billion transdermal skin patch market.

Negative

• None.

VANCOUVER, BC and UTTENWEILER, GERMANY / ACCESSWIRE / October 11, 2022 / XPhyto Therapeutics Corp. (CSE:XPHY)(OTCQB:XPHYF)(FSE:4XT) ("XPhyto" or the "Company") is pleased to provide a product development report on its Rotigotine transdermal ("TDS") patch. The Company's Rotigotine patch is based on the TDS platform technology developed by its wholly owned German subsidiary, Vektor Pharma TF GmbH ("Vektor").

Over the past 90 days, the Company has been focused on the optimization of its Rotigotine TDS formulation for the treatment of Parkinson's disease, with multiple novel but related formulas under development. After several rounds of skin permeation studies using mouse and human cadaver skin samples to compare Rotigotine absorption between XPhyto's formulas and the name brand product, XPhyto is pleased to announce that its Rotigotine TDS formula is complete.

Upon the recent formula completion, the Company carried out what it anticipates to be the final comparative human skin cadaver study. This study is now complete and analytical results are expected to be finalized and announced within the coming days.

Rotigotine is a non-ergoline dopamine agonist approved for the treatment of Parkinson's disease and restless legs syndrome (RLS) in Europe and the United States. The active pharmaceutical ingredient is not well absorbed via oral delivery and is formulated as a once-daily TDS patch to increase bioavailability and provide a slow and steady supply of the drug over the course of 24 hours. The therapeutic market for Parkinson's Disease is over 10 million people with PD worldwide and growing. The top selling name brand product launched by the originator in 2007 independently sold over $375 million of its Rotigotine TDS patches in 2021. According to Wissen Market Research, total global sales for Rotigotine patches were approximately US$518 million in 2021 with the market expected to surpass US$766 million by 2030.

XPhyto's Rotigotine transdermal product is a single product based on its 100% owned platform technology which represents a scalable opportunity for additional TDS drug development and manufacturing programs. According to Research and Markets, the global transdermal skin patch market had a value of nearly US$6.5 billion in 2020 while Kuick Research, Pharmaceutical and Healthcare, estimate the market will reach approximately US$20 billion by 2028.

Vektor, a wholly owned XPhyto subsidiary, is a German narcotics manufacturer, developer, and researcher located in the district of Biberach, Baden-Württemberg, Germany. For over a decade, the company and its team have been leaders in the design, testing and manufacture of innovative, non-invasive drug delivery systems, particularly transdermal patches and sub-lingual strips for the delivery of active pharmaceutical ingredients for the treatment of pain and neurological conditions. According to Precedence Research, the global drug delivery market was valued at US$1,476 billion in 2021 and is expected to grow to US$2,047 billion by 2030.

About XPhyto Therapeutics Corp.

XPhyto Therapeutics Corp. is a diversified bioscience accelerator focused on next-generation drug formulation, diagnostic, and new active pharmaceutical ingredient investment opportunities, including: precision transdermal and oral dissolvable drug formulations; rapid, low-cost infectious disease and oral health screening tests; and manufacture, standardization, and evaluation of psychedelic compounds for the treatment of neurological conditions. The Company has research and development operations in North America and Europe, with an operational focus in Germany, and is currently focused on regulatory approval and commercialization of medical products for European markets.

XPhyto Therapeutics Corp.

Hugh Rogers, CEO and Director

Investor inquiries:

T: 780-818-6422
E: info@xphyto.com

Forward looking statements

This news release includes statements containing forward-looking information within the meaning of applicable Canadian securities law ("forward-looking statements"). Forward-looking statements are frequently characterized by words such as "develop", "plan", "continue", "expect", "project", "intend", "believe", "anticipate", "estimate", "potential", "propose" and other similar words, or statements that certain events or conditions "may" or "will" occur, and in this release include the statement regarding the Company's goal of building a successful diagnostic, drug delivery, and medical cannabis company. Forward-looking statements are only predictions based on the opinions and estimates of management at the date the statements are made and are subject to a variety of risks and uncertainties and other factors that could cause actual events or results to differ materially from those projected in the forward-looking statements, including: that the Company may not succeed in developing a commercial product; that the sale of products may not be a viable business; that the Company may be unable to scale its business; product liability risks; product regulatory risk; general economic conditions; adverse industry events; future legislative and regulatory developments; inability to access sufficient capital from internal and external sources, and/or inability to access sufficient capital on favourable terms; currency risks; competition; international risks; and other risks beyond the Company's control. The Company is under no obligation, and expressly disclaims any intention or obligation, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as expressly required by applicable law. Neither the CSE nor its Market Regulator (as that term is defined in the policies of the CSE) accepts responsibility for the adequacy or accuracy of this news release.

SOURCE: XPhyto Therapeutics Corp.

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FAQ

What recent progress has XPhyto Therapeutics made with its Rotigotine patch?

XPhyto has completed the optimization of its Rotigotine transdermal patch formulation and finished a key comparative study on skin absorption.

When can we expect results from XPhyto's Rotigotine study?

Analytical results from the final comparative skin cadaver study are expected to be announced shortly.

What is the market outlook for XPhyto's Rotigotine patches?

The market for Rotigotine patches is expected to exceed US$766 million by 2030, indicating strong growth prospects.

What is the significance of the transdermal skin patch market for XPhyto?

The transdermal skin patch market is anticipated to reach US$20 billion by 2028, presenting substantial development opportunities for XPhyto.

What technology is XPhyto using for its Rotigotine patch?

XPhyto's Rotigotine patch is based on its proprietary transdermal delivery system developed by its subsidiary, Vektor Pharma.