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X4 Pharmaceuticals, Inc. (Nasdaq: XFOR) is a late-stage clinical biopharmaceutical company committed to the development of novel therapeutics aimed at improving immune cell trafficking and reversing immune suppression. The company's core focus is on treating rare diseases and conditions resulting from immune system dysfunction, including cancer and genetic primary immunodeficiency diseases.
X4’s lead clinical candidate, mavorixafor, is a selective, small-molecule antagonist of the chemokine receptor CXCR4. Designed as an oral, once-daily therapy, mavorixafor targets immune cell mobilization and has shown promising results in clinical trials. It is currently under priority review by the FDA for the treatment of WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome, a rare primary immunodeficiency. The company’s recent NDA submission is supported by positive results from the global, pivotal 4WHIM Phase 3 clinical trial, which demonstrated mavorixafor's ability to reduce infection rates and improve immune cell counts without serious adverse events.
In addition to mavorixafor for WHIM syndrome, X4 is advancing its pipeline with ongoing investigations for mavorixafor in chronic neutropenic disorders and other immunodeficiencies. The company has also initiated preclinical development of other CXCR4 antagonists, including X4P-002 and X4P-003, to address different properties and mechanisms within the immune system.
Headquartered in Boston, Massachusetts, with a research center in Vienna, Austria, X4 leverages its deep understanding of CXCR4 biology to innovate and bring transformative therapies to patients with limited treatment options. The company's mission is driven by a commitment to improve the lives of those affected by rare and severe immune diseases through rigorous scientific research and strategic investment in its proprietary pipeline.
For more updates and detailed information, visit X4 Pharmaceuticals.
X4 Pharmaceuticals (Nasdaq: XFOR) recently announced the issuance of an inducement award on April 30, 2021, under its 2019 Inducement Equity Incentive Plan. The award includes options to purchase 17,000 shares of common stock at an exercise price of $8.38 per share, reflecting the closing price on the grant date. These options will vest over four years and are aimed at attracting new talent. X4 focuses on developing therapies targeting CXCR4 pathway dysfunction, with its lead candidate, mavorixafor, currently undergoing Phase 3 clinical trials for WHIM syndrome.
X4 Pharmaceuticals (Nasdaq: XFOR) will report its Q1 2021 financial results on May 6, 2021. A conference call is scheduled for 8:30 a.m. ET, where updates on recent business highlights will also be discussed. The company is focused on developing therapies targeting CXCR4 pathway dysfunction, with its lead candidate mavorixafor undergoing Phase 3 trials for WHIM syndrome and Phase 1b trials for Waldenström macroglobulinemia and severe congenital neutropenia. Investors can access the call via phone or live webcast on its website.
X4 Pharmaceuticals (Nasdaq: XFOR) is set to present a corporate overview at the 20th Annual Needham Virtual Healthcare Conference on April 12, 2021, at 2:15 PM ET. The presentation will focus on their innovative therapies targeting the CXCR4 pathway, particularly the lead candidate, mavorixafor, a unique treatment aimed at rare diseases. A live webcast will be available on the company's website, with an archive accessible for 90 days following the event.
X4 Pharmaceuticals (Nasdaq: XFOR) announced on March 31, 2021, that its Board's Compensation Committee granted inducement awards under the 2019 Inducement Equity Incentive Plan. The awards consist of options to purchase a total of 58,000 shares at an exercise price of $8.61 per share, matching the stock's closing price on the grant date. These options will vest over four years, helping attract new employees to the company. X4 focuses on developing therapies targeting diseases related to the CXCR4 pathway, with its lead candidate being mavorixafor.
X4 Pharmaceuticals (Nasdaq: XFOR) announced a private investment in public equity (PIPE) financing, raising approximately $55 million by selling 6,321,837 shares of common stock at $8.70 per share. New and existing institutional investors participated, including Bain Capital Life Sciences and Abingworth. The funds will support the clinical development of X4's lead candidate, mavorixafor, aimed at treating rare diseases. Following the transaction, X4 intends to file a registration statement with the SEC for resale of shares.
X4 Pharmaceuticals (Nasdaq: XFOR) provided a financial update for Q4 and full year 2020, reporting a net loss of $62.1 million, up from $52.8 million in 2019. The company focuses on its lead candidate, mavorixafor, currently undergoing Phase 3 trials for WHIM syndrome and Phase 1b trials for Waldenström’s and SCN. X4 expects to complete enrollment in the WHIM trial in 2021, with data expected in 2022. The company also received Fast Track and Rare Pediatric Designations for mavorixafor from the FDA to address unmet needs in WHIM syndrome.
X4 Pharmaceuticals (Nasdaq: XFOR) is set to report its financial results for Q4 and the full year ended December 31, 2020, on March 4, 2021. The announcement includes insights into recent business highlights and will be followed by a conference call at 8:30 a.m. ET. The company specializes in therapies targeting the CXCR4 pathway, with its lead candidate mavorixafor undergoing various clinical trials. X4 aims to address rare diseases and those with limited treatment options, leveraging its expertise at its facilities in Boston and Vienna.
X4 Pharmaceuticals, Inc. (Nasdaq: XFOR) will participate in the B. Riley Oncology Institutional Investor Conference on January 20, 2021, at 11:00 AM ET. The event includes a fireside chat and one-on-one investor meetings. Due to audience limitations, advance registration is required. An archived webcast will be available on the X4 Pharmaceuticals website for 90 days post-event. The company focuses on developing therapies targeting CXCR4 pathway dysfunction, with its lead candidate mavorixafor currently in Phase 3 and Phase 1b clinical trials for various conditions.
X4 Pharmaceuticals (Nasdaq: XFOR) has announced its participation in the H.C. Wainwright Virtual BioConnect Conference from January 11-14, 2021. The company's management will present on their innovative therapies targeting CXCR4 pathway dysfunction. An on-demand webcast of the presentation will be accessible on X4's investor website starting January 11, and it will remain available for about 90 days post-conference. X4 is focused on rare diseases with limited treatment options, and its lead candidate, mavorixafor, is currently in pivotal clinical trials.
X4 Pharmaceuticals (Nasdaq: XFOR) announced on January 4, 2021, that its Board of Directors granted inducement awards to new employees under the 2019 Inducement Equity Incentive Plan. This includes options to purchase 156,050 shares at an exercise price of $6.43, equal to the stock's closing price on November 30, 2020. The options will vest over four years, contingent on continued employment. X4 focuses on developing therapies targeting diseases from CXCR4 pathway dysfunction, with its lead candidate, mavorixafor, in advanced clinical trials for conditions like WHIM syndrome.
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