Welcome to our dedicated page for Xenetic Biosciences news (Ticker: XBIO), a resource for investors and traders seeking the latest updates and insights on Xenetic Biosciences stock.
Overview
Xenetic Biosciences Inc (NASDAQ: XBIO) is a clinical-stage biopharmaceutical company dedicated to the discovery, research, and development of next-generation biologic drugs and novel oncology therapeutics. With a strong emphasis on immuno-oncology, the company leverages innovative approaches to address hard-to-treat cancers, harnessing state-of-the-art technologies to improve patient outcomes. Its focus on clinical precision and advanced targeted treatments positions it uniquely within the competitive landscape of biopharma companies.
Core Technologies and Platforms
At the heart of Xenetic's research is its proprietary DNase-based oncology platform. This technology is designed to optimize existing therapies by targeting neutrophil extracellular traps (NETs), key biological structures implicated in cancer progression and resistance to treatment. By breaking down NETs in the tumor microenvironment, Xenetic’s approach enhances the efficacy of immunotherapies, adoptive cell therapy, and conventional chemotherapies. In addition, the company has developed polyxen™, a unique platform that enhances the pharmacological properties of biologic drugs, improving longevity and performance in the body.
Product Pipeline and Platform Applications
Xenetic Biosciences is advancing several investigational product candidates across its pipeline. Notable among them is an orphan-designated oncology therapeutic, specifically targeting cancers such as progesterone receptor negative endometrial cancer. The company is also exploring a personalized CAR T platform, which is part of its efforts to tailor cancer treatments to individual patient profiles. Moreover, its DNase platform is under active evaluation in combination with standard-of-care therapies for solid tumors, such as pancreatic carcinoma and colorectal cancers, aiming to overcome the immunosuppressive tumor microenvironment.
Collaborations and Strategic Partnerships
To bolster its research and clinical development initiatives, Xenetic has entered into significant collaborations with notable industry partners. Partnerships with established biopharmaceutical companies and academic institutions have provided strategic advantages such as enhanced research funding, advanced preclinical studies, and shared technical expertise. These collaborations are central to Xenetic’s approach of integrating its proprietary technologies with established treatment regimens to augment therapeutic efficacy.
Market Position and Competitive Landscape
Operating at the forefront of immuno-oncology, Xenetic Biosciences Inc is positioned within a highly specialized segment of the biopharmaceutical industry. The company differentiates itself through its dual focus on both biologic drug enhancement (via polyxen™) and innovative immune-oncology strategies (using its DNase platform). With a robust research pipeline and strategic partnerships, it navigates a complex competitive landscape by focusing on therapeutic areas that represent significant unmet medical needs.
Expertise and Scientific Rationale
The scientific foundation of Xenetic's work is reinforced by extensive preclinical research. The company emphasizes rigorous experimental data to support its novel approaches, particularly in dissecting the role of NETs in tumor biology. This deep dive into mechanistic insights not only validates their therapeutic pathways but also illustrates a commitment to building long-term, evidence-based interventions. The detailed explanations of advanced concepts, such as how degradation of NETs can potentiate immune checkpoint blockade, underscore the company’s expertise and scientific rigor.
Conclusion
Overall, Xenetic Biosciences Inc provides a comprehensive approach to tackling some of the most challenging cancers today. By integrating cutting-edge biotechnologies with strategic research initiatives, the company is dedicated to enhancing treatment outcomes and expanding the therapeutic landscape of oncology. Its ongoing efforts in both product development and collaborative research exemplify a deep commitment to scientific advancement and clinical innovation.
Xenetic Biosciences (NASDAQ:XBIO) has announced that its collaboration partner, PeriNess, has entered into a Clinical Study Agreement for an exploratory clinical study of XBIO-015, a systemic DNase I candidate, in patients with relapsed/refractory osteosarcoma and Ewing sarcoma.
The study, to be conducted at Tel-Aviv Sourasky Medical Center, will primarily assess safety and tolerability of XBIO-015 in combination with relapsed chemotherapy regimens. Secondary objectives include evaluating efficacy through objective response rate and progression-free survival.
Research conducted at the center between 2013-2024 revealed that neutrophil extracellular traps (NETs) in pediatric sarcomas' tumor microenvironment is a prognostic factor, with higher NETs burden correlating to poor prognosis. XBIO-015, a recombinant DNase I enzyme, works by digesting these NETs.
This initiative follows Xenetic's December 2024 agreement with PeriNess for exploratory studies of recombinant DNase in pancreatic carcinoma and other solid tumors at Israeli medical centers.
Xenetic Biosciences (NASDAQ:XBIO) reported its financial results for FY2024, highlighting progress in its DNase-based technology development for cancer treatment. The company recorded a net loss of $4.0 million, with R&D expenses decreasing 5.9% to $3.3 million and G&A expenses declining 4.1% to $3.4 million.
Key developments include extended collaborations with the University of Virginia and Scripps Research through 2025, and a new Clinical Trial Services Agreement with PeriNess for investigator-initiated studies. The company maintained stable royalty payments of $2.5 million from its Takeda Pharmaceuticals sublicense and ended the year with $6.2 million in cash.
Xenetic's focus remains on advancing its DNase-based technology toward IND and Phase 1 clinical trials for pancreatic carcinoma and other solid tumors, with preliminary preclinical studies completed in colorectal cancer models.
Xenetic Biosciences (NASDAQ:XBIO) presented positive preclinical data at the SITC Spring Scientific 2025 Cell Therapy Meeting, demonstrating the potential of DNase I as an adjunctive treatment to enhance immunotherapeutic responses.
The study investigated co-administration of DNase I with CAR T cells in a melanoma model, showing that a single injection of DNase I (10 mg/kg) with CAR T cells effectively suppressed lung metastasis at early stages. The combination treatment led to:
- Marked suppression of tumor burden
- Decreased metastatic foci
- Prolonged survival compared to CAR T cell monotherapy
- Increased tumor-infiltrating T and CAR T cells
- Reduced T cell exhaustion markers (PD-1 and TIM-3)
The company is advancing its DNase-based technology towards Phase 1 clinical trials for pancreatic carcinoma and other solid tumors.
Xenetic Biosciences (NASDAQ:XBIO) announced that its abstract has been accepted for poster presentation at the Society for Immunotherapy of Cancer (SITC) Spring Scientific 2025 Cell Therapy Meeting. The event will be held from March 12-14, 2025, in San Diego, CA, with a virtual component.
The presentation, titled 'DNase I Intervention Enhances CAR-T Cell Therapy in Solid Tumors by Targeting Neutrophil Extracellular Traps in Metastatic Melanoma', will be delivered by Dr. Alexey Stepanov from The Scripps Research Institute on March 12, 2025, at 5:10 p.m. PT.
Xenetic Biosciences (NASDAQ:XBIO) announced that Dr. Reid Bissonnette, Executive Consultant for Translational Research and Development, participated in a Virtual Investor 'What This Means' segment. The segment focuses on discussing the company's recently announced extension of its Research Agreement with the University of Virginia for advancing its DNase-Based oncology platform, which aims to address hard-to-treat cancers.
Literacy Texas, a Regions Bank customer and nonprofit organization, is addressing critical literacy challenges in Texas under the leadership of Executive Director Jenny Walker. The organization serves as a support network, collaborating with over 300 nonprofits and government agencies to improve adult and family literacy through resources, training, and advocacy.
Key statistics reveal that 28% of Texas is at level one for reading, and 40% of the population reads at a third-grade level. The organization focuses on developing workforce skills, improving digital literacy, and bridging the technological divide, particularly in rural communities. Low literacy rates nationally cost the U.S. approximately $200 billion in safety and health issues and over $2 trillion in lost productivity annually.
Xenetic Biosciences (NASDAQ:XBIO) has extended its Research Funding Agreement with the University of Virginia (UVA) through 2025 to advance its DNase-based oncology platform. The program targets neutrophil extracellular traps (NETs) in the tumor microenvironment, which promote cancer spread and immunosuppression. Preclinical studies have shown that reducing NETs burden with Xenetic's recombinant human DNase I improves the efficacy of immunotherapy, adoptive cell therapy, and chemotherapy.
The company maintains an option to exclusively license new intellectual property from the research program. UVA will continue investigating DNase I combinations with immunotherapies in primary and metastatic colorectal cancer models. Xenetic is progressing toward its first-in-human study to evaluate DNase combined with immune checkpoint inhibitors or chemotherapy.
Xenetic Biosciences (NASDAQ:XBIO) has entered into a Clinical Trial Services Agreement with Israel-based PeriNess to advance its systemic DNase I oncology program. The collaboration aims to develop XBIO-015, a DNase I candidate, as an adjunctive treatment in combination with chemotherapy and immunotherapy for pancreatic carcinoma, colorectal cancer, and other advanced solid tumors.
Under the agreement, PeriNess will lead regulatory approval and manage potential exploratory studies in Israeli medical centers. The partnership leverages PeriNess' expertise in clinical development of human recombinant DNase. Preclinical data supports DNase I's role in improving therapeutic responses by targeting Neutrophil Extracellular Traps (NETs) in cancer treatment.
Xenetic Biosciences (NASDAQ:XBIO) released a Virtual Investor segment featuring Dr. Reid Bissonnette discussing recent preclinical data presented at the SITC 39th Annual Meeting. The data shows that DNase I significantly improves the effectiveness of anti-CTLA-4 immune checkpoint blockade in preclinical models of microsatellite stable/mismatch repair proficient (MSS/MMRp) colorectal carcinoma. This is particularly significant as MSS/MMRp CRC affects approximately 85% of colorectal cancer patients, a group that has historically shown response to immune checkpoint blockade treatments.
Xenetic Biosciences (NASDAQ:XBIO) presented positive preclinical data showing the potential of co-administering DNase I with CAR T cells in treating melanoma lung metastasis. The study demonstrated that a single injection of DNase I (10 mg/kg) with EGFR-CAR T cells significantly suppressed metastatic tumor burden and extended survival compared to CAR T cell therapy alone. Key findings showed that DNase I increases tumor-infiltrating T and CAR T cells while reducing immunosuppressive effects. The research supports DNase I's potential as an adjunctive treatment to improve CAR T cell therapy responses, particularly in solid tumors where traditional CAR T cell therapy has shown efficacy.
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