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Wave Life Sciences Ltd. Ordinary Shares - WVE STOCK NEWS

Welcome to our dedicated page for Wave Life Sciences Ltd. Ordinary Shares news (Ticker: WVE), a resource for investors and traders seeking the latest updates and insights on Wave Life Sciences Ltd. Ordinary Shares stock.

Wave Life Sciences Ltd. (Nasdaq: WVE) is a clinical-stage biotechnology company harnessing its groundbreaking synthetic chemistry platform to create stereopure nucleic acid therapeutics. Focused on rare genetic diseases, Wave's pipeline addresses conditions such as alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy (DMD), and Huntington's disease. Wave's proprietary PRISMTM platform integrates various RNA modalities, including RNA editing, antisense, exon-skipping, and RNA interference, enabling scientific breakthroughs that address both rare and common disorders.

Recently, Wave has made significant progress with its Phase 2 FORWARD-53 trial for DMD, showing promising results with WVE-N531. This trial, which began dosing in December 2023, aims to evaluate dystrophin protein generation in boys amenable to exon 53 skipping, with critical data expected in 2024. The company also anticipates delivering first-of-its-kind RNA editing proof-of-mechanism data in 2024 for its WVE-006 program, targeting alpha-1 antitrypsin deficiency.

Financially, Wave is well-capitalized, with substantial cash inflows and strategic partnerships, including a notable collaboration with GSK. This partnership has led to significant milestone payments and the initiation of development programs utilizing Wave's advanced GalNAc-siRNA format.

Wave Life Sciences is at the forefront of RNA medicine, driven by a commitment to transform human health and provide life-changing treatments for devastating diseases.

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Wave Life Sciences Ltd. (Nasdaq: WVE) has commenced an underwritten public offering of $100 million in aggregate of its ordinary shares, and pre-funded warrants to purchase ordinary shares. The offering is subject to market and other conditions, with J.P. Morgan and Leerink Partners acting as joint book-running managers. The company intends to grant the underwriters a 30-day option to purchase ordinary shares in an amount up to an additional 15% of the total amount of ordinary shares and pre-funded warrants sold in the public offering on the same terms and conditions.
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Wave Life Sciences Ltd. (Nasdaq: WVE) announced the initiation of dosing in healthy volunteers in the RestorAATion clinical trial program, investigating WVE-006 as a potential treatment for alpha-1 antitrypsin deficiency (AATD). WVE-006 is a first-in-class, GalNAc-conjugated RNA editing oligonucleotide designed to restore circulation of healthy, wild-type alpha-1 antitrypsin (M-AAT) protein and reduce dysfunctional Z-AAT protein, addressing AATD-related lung disease, liver disease, or both. Wave earned a $20 million USD milestone from GSK for initiation of dosing and is eligible for additional milestones of up to $505 million for WVE-006. Proof-of-mechanism data in individuals with AATD, as measured by restoration of M-AAT protein, is expected in 2024. Wave is also advancing a pipeline of wholly owned RNA editing therapeutics beyond WVE-006 and across a range of high-impact GalNAc-hepatic and extra hepatic targets.
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Wave Life Sciences Ltd. (WVE) CEO Paul Bolno to participate in fireside chat at Evercore ISI HealthCONx Conference on Nov. 29, 2023
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Wave Life Sciences Ltd. (Nasdaq: WVE) announced the initiation of the RestorAATion clinical program for WVE-006, the industry’s first RNA editing clinical candidate. The program is set to investigate WVE-006 as a treatment for alpha-1 antitrypsin deficiency (AATD). Additionally, the company announced progress in their WVE-N531 and WVE-003 clinical development programs and presented preclinical proof-of-concept data for a new GalNAc-siRNA program targeting INHBE for metabolic disorders, including obesity. The company also reported cash and cash equivalents of $140 million as of September 30, 2023, with a runway expected into 2025.
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Wave Life Sciences Ltd. will host a live webcast and conference call on November 9, 2023, to review their third quarter 2023 financial results and provide business updates. Analysts can join the conference call and a recorded version will be available on the company's website.
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Wave Life Sciences presents preclinical proof-of-concept data for new program targeting INHBE for metabolic disorders, including obesity. INHBE loss-of-function carriers exhibit reduced waist-to-hip circumference and reduced odds ratio of Type 2 Diabetes. Reduction in INHBE of 50% or greater is expected to restore a healthy metabolic profile. Wave expects to select an INHBE clinical candidate in 4Q 2024. Wave also announces progress in siRNA and RNA editing programs. Wave expects to select five new clinical candidates by year-end 2025.
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Wave Life Sciences to present at Chardan Genetic Medicines Conference
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Wave Life Sciences to participate in virtual fireside chat at H.C. Wainwright conference
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Wave Life Sciences submits first clinical trial application for WVE-006 in alpha-1 antitrypsin deficiency (AATD)
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Wave Life Sciences Ltd. (Nasdaq: WVE) announced financial results for Q2 2023 and provided a business update, including clinical trial updates, upcoming milestones, and financial data. The company reported a net loss of $21.1 million, with $173.0 million in cash and cash equivalents as of June 30, 2023.
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FAQ

What is the current stock price of Wave Life Sciences Ltd. Ordinary Shares (WVE)?

The current stock price of Wave Life Sciences Ltd. Ordinary Shares (WVE) is $14.27 as of November 22, 2024.

What is the market cap of Wave Life Sciences Ltd. Ordinary Shares (WVE)?

The market cap of Wave Life Sciences Ltd. Ordinary Shares (WVE) is approximately 2.2B.

What is Wave Life Sciences Ltd.?

Wave Life Sciences Ltd. (Nasdaq: WVE) is a biotechnology company focused on developing stereopure nucleic acid therapeutics for genetic diseases using its proprietary PRISMTM platform.

What diseases is Wave targeting?

Wave Life Sciences is developing treatments for diseases such as alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington's disease.

What is the PRISMTM platform?

PRISMTM is Wave's proprietary platform that combines multiple RNA modalities, chemistry innovation, and genetic insights to create RNA-targeting therapies.

What is the FORWARD-53 trial?

FORWARD-53 is a Phase 2 trial evaluating WVE-N531 for boys with Duchenne muscular dystrophy amenable to exon 53 skipping. It aims to assess dystrophin protein levels and safety.

What recent achievements has Wave Life Sciences made?

Wave has initiated dosing in the FORWARD-53 trial, advanced its WVE-006 program, and received significant milestone payments through its partnership with GSK.

How is Wave Life Sciences funded?

Wave Life Sciences is well-capitalized with substantial cash inflows, including $142 million in Q4 2023 and additional payments under existing collaborations.

What is WVE-006?

WVE-006 is Wave's RNA editing candidate for alpha-1 antitrypsin deficiency, designed to restore functional M-AAT protein and expected to provide proof-of-mechanism data in 2024.

What is the significance of the partnership with GSK?

The partnership with GSK allows Wave to advance multiple RNA-targeting programs, providing substantial milestone payments and leveraging Wave's PRISMTM platform.

What is Wave's approach to RNA medicines?

Wave Life Sciences employs a multimodal approach, utilizing RNA editing, splicing, RNA interference, and antisense silencing to design precise, effective therapies.

Where is Wave Life Sciences headquartered?

Wave Life Sciences is headquartered in Cambridge, Massachusetts.

Wave Life Sciences Ltd. Ordinary Shares

Nasdaq:WVE

WVE Rankings

WVE Stock Data

2.16B
129.41M
15.04%
78.49%
4.48%
Biotechnology
Pharmaceutical Preparations
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