Waters Sets New Standard in High Resolution Mass Spectrometry with SELECT SERIES Multi Reflecting Time-of-Flight Platform

Rhea-AI Summary

Waters Corporation (NYSE:WAT) has launched the Waters™ SELECT SERIES™ MRT, an advanced mass spectrometer integrating Multi Reflecting Time-of-Flight (MRT) technology with enhanced DESI and new MALDI imaging sources. This device allows for rapid, precise identification of molecules, achieving speeds of up to 10Hz without losing mass accuracy. The SELECT SERIES MRT boasts a resolution of 200,000 FWHM, setting a new standard in mass spectrometry. Shipments are slated to begin in Q4 of this year, promising significant advancements in biological research and imaging applications.

Positive

• Launch of SELECT SERIES MRT enhances Waters' product lineup.
• Achieves resolution of 200,000 FWHM and part-per-billion mass accuracy.
• Increases speed of molecular analysis to up to 10Hz.
• Integration of DESI and MALDI imaging expands research capabilities.

Negative

• None.

Waters Corporation (NYSE:WAT) today introduced the Waters™ SELECT SERIES™ MRT, a high-resolution mass spectrometer that combines Multi Reflecting Time-of-Flight (MRT) technology with both enhanced DESI and new MALDI imaging sources. Together, these technologies enable scientists to explore molecular structure and function through the precise identification and localization of individual molecules in samples, with a unique combination of speed, resolution, and mass accuracy.

The Waters SELECT SERIES MRT allows scientists to explore molecular structure and function by precisely identifying and mapping the location of molecules on a test sample’s surface with speed, resolution and mass accuracy. (Photo: Business Wire)

For example, a scientist researching how an investigational oncology drug interacts with its intended target, such as a specific brain tumor receptor, can now do so much faster, at speeds up to 10Hz without compromising mass accuracy or resolution.

“The Waters SELECT SERIES MRT opens the door to a greater understanding of molecules and their mechanisms of action in numerous scientific fields,” said Dr. Udit Batra, CEO and President, Waters Corporation. “The clarity of images produced by this instrument can yield profoundly important molecular information to scientists in research areas such as targeted therapeutics, to provide insights and enable deep biological discoveries.”

The SELECT SERIES MRT platform is the basis for the next generation of Waters’ high-resolution mass spectrometers. It is the first commercially available instrument of its kind that is capable of attaining 200,000 Full Width Half Maximum (FWHM) resolution and part-per-billion mass accuracy independent of scan speed. The superior performance of the SELECT SERIES MRT allows scientists to get the highest quality mass spectrometry data and information faster than any commercial mass spectrometer on the market todayⁱⁱ. The new Multi Reflecting Time-of-Flight technology features an extended flight path of almost 50 meters to give scientists a much clearer picture of structural information, including fine isotope structure.

DESI XS and MALDI Imaging on a Single MRT Platform

The first application of the SELECT SERIES MRT unlocks the potential of MS imaging using DESI and MALDI ionization. DESI is a direct-from-sample, soft ionization technique performed under ambient environmental conditions, requiring no prior sample preparation. It provides imaging information about the biochemical distribution of small molecule drugs, lipids, and naturally occurring metabolites within a slice of tissue or on other sample surfaces after just a single measurement. Scientists are applying DESI today to research breast and ovarian cancer, to study drug metabolism and pharmacokinetics (DMPK), to investigate the function of key metabolites in natural products in traditional medicines, and to get a closer look at the biotransformation of bacterial colonies after gene modifications.

Featuring a new high-performance sprayer and a heated transfer line, the advanced DESI XS source delivers new levels of usability, image clarity and sensitivity at high speed, bringing more accessible imaging to scientists through mass spectrometry data.

For scientists interested in conducting MALDI imaging experiments, the SELECT SERIES MRT is available with a newly designed MALDI source. MALDI is an ideal complementary technique for the imaging of biological molecules such as peptides and can visualize tissue sections at spatial resolutions of less than 10 microns. Taken together, the combination of imaging sources gives researchers the means to generate fine spatial information and morphological detail for biological samples and even visualize brain vasculature. Customer shipments of the SELECT SERIES MRT are expected to begin in the fourth quarter of this year.

Additional Resources

• Learn more about the Waters SELECT SERIES MRT
• Watch the SELECT SERIES MRT product video
• Learn more about the Waters DESI XS source
• Read the blog: New SELECT SERIES MRT Redefines Performance of Next Generation High-Resolution Mass Spectrometry
• Connect with Waters via LinkedIn, Twitter, and Facebook

About Waters Corporation (www.waters.com)

Waters Corporation (NYSE:WAT), the world's leading specialty measurement company, has pioneered chromatography, mass spectrometry, and thermal analysis innovations serving the life, materials, food and environmental sciences for more than 60 years. With more than 7,400 employees worldwide, Waters operates directly in 35 countries, including 14 manufacturing facilities, and with products available in more than 100 countries.

Waters and SELECT SERIES are trademarks of Waters Corporation.

 

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ⁱ Waters SELECT SERIES MRT mass resolution >200k FWHM @ m/z 785 and independent of scan time; highest resolution achieved irrespective of scan rate

ⁱⁱ See above

View source version on businesswire.com: https://www.businesswire.com/news/home/20210608006036/en/

FAQ

What is the significance of the Waters SELECT SERIES MRT?

The Waters SELECT SERIES MRT is a high-resolution mass spectrometer designed to enable faster and more accurate molecular analysis, revolutionizing research in various scientific fields.

When will the SELECT SERIES MRT be available for customers?

Customer shipments of the SELECT SERIES MRT are expected to begin in the fourth quarter of this year.

What technologies does the SELECT SERIES MRT combine?

The SELECT SERIES MRT combines Multi Reflecting Time-of-Flight (MRT) technology with enhanced DESI and new MALDI imaging sources.

How fast can the SELECT SERIES MRT analyze samples?

The SELECT SERIES MRT can analyze samples at speeds of up to 10Hz.