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Verastem, Inc. - VSTM STOCK NEWS

Welcome to our dedicated page for Verastem news (Ticker: VSTM), a resource for investors and traders seeking the latest updates and insights on Verastem stock.

Verastem, Inc. (NASDAQ: VSTM) is a pioneering biopharmaceutical company dedicated to discovering and developing innovative drugs that target cancer stem cells. These cells are a significant factor in tumor recurrence and metastasis, posing a substantial challenge in the treatment of various cancers. Verastem's mission is to translate groundbreaking cancer stem cell research into new medicines that address major cancers, including breast cancer.

The core focus of Verastem lies in advancing novel anticancer agents, particularly those inhibiting critical signaling pathways that promote cancer cell survival and tumor growth. This includes the development of RAF/MEK inhibitors and FAK inhibitors. These targeted therapies are designed to intercept the mechanisms that allow cancer cells to thrive and spread, offering hope for more effective treatments.

One of the company's notable projects involves the combination of avutometinib (a RAF/MEK clamp) and defactinib (a FAK inhibitor). This drug combination has shown promising results and has been granted breakthrough therapy designation for treating recurrent low-grade serous ovarian cancer (LGSOC), regardless of KRAS status, after one or more prior lines of therapy, including platinum-based chemotherapy.

Verastem has also entered into a strategic partnership with GenFleet Therapeutics, a clinical-stage biotechnology company. This collaboration aims to advance three oncology programs, with GFH375 being the first selected candidate. GFH375, an oral KRAS G12D inhibitor, targets both the

News

Verastem Oncology Announces Multiple Oral Presentations at SGO 2024 Annual Meeting on Women’s Cancer that Highlight Advances in Low-Grade Serous Ovarian Cancer Research and Reinforce Commitment to Addressing Urgent Unmet Needs

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Verastem Oncology (Nasdaq: VSTM) presented multiple oral and poster presentations at the SGO 2024 Annual Meeting on Women’s Cancer. The presentations included a late-breaking oral presentation of avutometinib and defactinib combination data from the RAMP 201 Part A trial in heavily pretreated patients with low-grade serous ovarian cancer.
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Verastem Oncology Receives Orphan Drug Designation from FDA for Avutometinib Alone or in Combination With Defactinib in Recurrent Low-Grade Serous Ovarian Cancer

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Verastem Oncology receives FDA Orphan Drug Designation for avutometinib and defactinib in recurrent low-grade serous ovarian cancer, aiming for Accelerated Approval in 2024. The company is addressing a rare cancer with no approved treatments, impacting a significant patient population.
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Verastem Oncology Announces Preclinical Presentations for New Oral G12D Inhibitor and for Avutometinib and Defactinib Combination as a Backbone of Therapy for RAS/MAPK Driven Cancers at AACR Annual Meeting 2024

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Verastem Oncology announces promising preclinical data on GFH375 (VS-7375) and avutometinib-FAK inhibitor combination for pancreatic and colorectal cancer treatment. Partner GenFleet to submit IND in H1 2024. Key presentations at AACR Annual Meeting 2024.
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Verastem Oncology Outlines Key 2024 Strategic Priorities and Upcoming Catalysts for Advancing Avutometinib and Defactinib and Broader Pipeline in RAS Pathway-Driven Cancers

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Verastem Oncology (VSTM) plans to submit an NDA for Accelerated Approval for the combination of avutometinib and defactinib in recurrent low-grade serous ovarian cancer in the first half of 2024. They also aim to provide data read-outs with avutometinib and defactinib combinations in KRAS G12C-mutant non-small cell lung cancer and frontline metastatic pancreatic cancer, as well as supporting their collaborator GenFleet in advancing oral KRAS G12D inhibitor GFH375/VS-7375 into a Phase 1 clinical trial this year.
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Verastem Oncology Granted Fast Track Designation for Combination of Avutometinib and Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer (NSCLC)

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Verastem Oncology (VSTM) announced that the FDA has granted Fast Track Designation to its investigational RAF/MEK clamp, avutometinib, in combination with Amgen’s KRAS G12C inhibitor, LUMAKRASTM (sotorasib), for the treatment of patients with KRAS G12C-mutant metastatic non-small cell lung cancer (NSCLC). Initial RAMP 203 trial results showed confirmed responses in both KRAS G12C inhibitor resistant and naïve patients. Enrollment is ongoing in the expansion phase, with updated results expected in the first half of 2024.
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Verastem Oncology to Participate in the B. Riley Securities 4th Annual Oncology Conference

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Verastem Oncology (VSTM) to participate in fireside chat at B. Riley Securities 4th Annual Oncology Conference on January 18, 2024
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Verastem Oncology Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

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Verastem Oncology (VSTM) Grants Stock Options to New Employees
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Verastem Oncology Selects Oral KRAS G12D Inhibitor GFH375/VS-7375 as Lead Program in Discovery and Development Collaboration with GenFleet Therapeutics

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Verastem Oncology (Nasdaq: VSTM) plans to submit an Investigational New Drug (IND) for GFH375/VS-7375, an oral inhibitor targeting KRAS G12D, the most prevalent KRAS mutation in human cancer, in the first half of 2024. The potential best-in-class inhibitor is the lead program from Verastem's collaboration with GenFleet Therapeutics. The company aims to address the lack of FDA-approved therapies targeting KRAS G12D, which represents 26% of all KRAS mutations. The collaboration with GenFleet aims to advance three oncology discovery programs related to RAS pathway-driven cancers, with Verastem having the exclusive option to obtain a license to each of the three compounds after successful completion of pre-determined milestones in a Phase 1 trial.
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Verastem Oncology Announces Initiation of a Confirmatory Phase 3 Trial of Avutometinib and Defactinib in Recurrent Low-Grade Serous Ovarian Cancer

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Verastem Oncology (VSTM) initiates Phase 3 RAMP 301 trial to evaluate avutometinib and defactinib combination for recurrent low-grade serous ovarian cancer. The combination reports an objective response rate of 45% with manageable safety and tolerability profile. The company plans to submit an Accelerated Approval NDA based on mature data from RAMP 201 and FRAME trials.
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New Healthcare Professional Component of Let’s Talk About LGSOC to Raise Awareness of Low-Grade Serous Ovarian Cancer as a Distinct and Different Form of Ovarian Cancer Requiring Tailored Resources and Treatment Approach

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Let's Talk (LT) announces a new partnership with healthcare professionals and patients, aiming to enhance healthcare communication. The initiative focuses on improving patient-doctor dialogue and fostering better understanding of medical conditions and treatment options. This collaboration seeks to address the need for more effective communication in healthcare.
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FAQ

What is the current stock price of Verastem (VSTM)?

The current stock price of Verastem (VSTM) is $5.9 as of January 8, 2025.

What is the market cap of Verastem (VSTM)?

The market cap of Verastem (VSTM) is approximately 281.7M.

What does Verastem, Inc. specialize in?

Verastem, Inc. specializes in developing novel drugs that target cancer stem cells to treat various major cancers, including breast cancer.

What are some of Verastem's key projects?

Verastem is working on RAF/MEK and FAK inhibitors to treat cancer. They are also developing a combination therapy of avutometinib and defactinib for low-grade serous ovarian cancer.

Who are Verastem's partners?

One of Verastem's key partners is GenFleet Therapeutics, with whom they are collaborating to advance oncology programs targeting KRAS mutations.

What is GFH375?

GFH375 is an oral KRAS G12D inhibitor being developed in collaboration with GenFleet Therapeutics. It targets cancer cells with KRAS G12D mutations.

What makes Verastem's approach unique?

Verastem focuses on cancer stem cells, aiming to develop therapies that prevent tumor recurrence and metastasis, a major challenge in cancer treatment.

What are RAF/MEK and FAK inhibitors?

RAF/MEK and FAK inhibitors are drugs that target specific signaling pathways in cancer cells, hindering their growth and survival.

What types of cancer is Verastem targeting?

Verastem is targeting major cancers, including breast cancer, ovarian cancer, and those with KRAS mutations.

What recent achievements has Verastem made?

Verastem's combination therapy of avutometinib and defactinib has been granted breakthrough therapy designation for treating recurrent low-grade serous ovarian cancer.

How does Verastem's partnership with GenFleet Therapeutics benefit their research?

The partnership allows Verastem to leverage GenFleet's expertise in oncology to advance new therapies targeting KRAS mutations, enhancing their oncology pipeline.

Where can I find more information about Verastem, Inc.?

More information can be found on their official website: www.verastem.com.
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Verastem, Inc.

Nasdaq:VSTM

VSTM Rankings

#3606 Ranked by Market Cap
N/A Ranked by Dividends

VSTM Stock Data

281.73M
41.25M
0.82%
59.92%
5.89%
Biotechnology
Pharmaceutical Preparations
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United States of America
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