STOCK TITAN

Verastem, Inc. - VSTM STOCK NEWS

Welcome to our dedicated page for Verastem news (Ticker: VSTM), a resource for investors and traders seeking the latest updates and insights on Verastem stock.

Verastem, Inc. (NASDAQ: VSTM) is a pioneering biopharmaceutical company dedicated to discovering and developing innovative drugs that target cancer stem cells. These cells are a significant factor in tumor recurrence and metastasis, posing a substantial challenge in the treatment of various cancers. Verastem's mission is to translate groundbreaking cancer stem cell research into new medicines that address major cancers, including breast cancer.

The core focus of Verastem lies in advancing novel anticancer agents, particularly those inhibiting critical signaling pathways that promote cancer cell survival and tumor growth. This includes the development of RAF/MEK inhibitors and FAK inhibitors. These targeted therapies are designed to intercept the mechanisms that allow cancer cells to thrive and spread, offering hope for more effective treatments.

One of the company's notable projects involves the combination of avutometinib (a RAF/MEK clamp) and defactinib (a FAK inhibitor). This drug combination has shown promising results and has been granted breakthrough therapy designation for treating recurrent low-grade serous ovarian cancer (LGSOC), regardless of KRAS status, after one or more prior lines of therapy, including platinum-based chemotherapy.

Verastem has also entered into a strategic partnership with GenFleet Therapeutics, a clinical-stage biotechnology company. This collaboration aims to advance three oncology programs, with GFH375 being the first selected candidate. GFH375, an oral KRAS G12D inhibitor, targets both the

Rhea-AI Summary
Verastem Oncology (VSTM) plans to submit an NDA for Accelerated Approval for the combination of avutometinib and defactinib in recurrent low-grade serous ovarian cancer in the first half of 2024. They also aim to provide data read-outs with avutometinib and defactinib combinations in KRAS G12C-mutant non-small cell lung cancer and frontline metastatic pancreatic cancer, as well as supporting their collaborator GenFleet in advancing oral KRAS G12D inhibitor GFH375/VS-7375 into a Phase 1 clinical trial this year.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
7.12%
Tags
none
-
Rhea-AI Summary
Verastem Oncology (VSTM) announced that the FDA has granted Fast Track Designation to its investigational RAF/MEK clamp, avutometinib, in combination with Amgen’s KRAS G12C inhibitor, LUMAKRASTM (sotorasib), for the treatment of patients with KRAS G12C-mutant metastatic non-small cell lung cancer (NSCLC). Initial RAMP 203 trial results showed confirmed responses in both KRAS G12C inhibitor resistant and naïve patients. Enrollment is ongoing in the expansion phase, with updated results expected in the first half of 2024.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
7.51%
Tags
-
Rhea-AI Summary
Verastem Oncology (VSTM) to participate in fireside chat at B. Riley Securities 4th Annual Oncology Conference on January 18, 2024
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
2.01%
Tags
conferences
Rhea-AI Summary
Verastem Oncology (VSTM) Grants Stock Options to New Employees
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
0.24%
Tags
none
-
Rhea-AI Summary
Verastem Oncology (Nasdaq: VSTM) plans to submit an Investigational New Drug (IND) for GFH375/VS-7375, an oral inhibitor targeting KRAS G12D, the most prevalent KRAS mutation in human cancer, in the first half of 2024. The potential best-in-class inhibitor is the lead program from Verastem's collaboration with GenFleet Therapeutics. The company aims to address the lack of FDA-approved therapies targeting KRAS G12D, which represents 26% of all KRAS mutations. The collaboration with GenFleet aims to advance three oncology discovery programs related to RAS pathway-driven cancers, with Verastem having the exclusive option to obtain a license to each of the three compounds after successful completion of pre-determined milestones in a Phase 1 trial.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
2.63%
Tags
none
-
Rhea-AI Summary
Verastem Oncology (VSTM) initiates Phase 3 RAMP 301 trial to evaluate avutometinib and defactinib combination for recurrent low-grade serous ovarian cancer. The combination reports an objective response rate of 45% with manageable safety and tolerability profile. The company plans to submit an Accelerated Approval NDA based on mature data from RAMP 201 and FRAME trials.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
10.67%
Tags
Rhea-AI Summary
Let's Talk (LT) announces a new partnership with healthcare professionals and patients, aiming to enhance healthcare communication. The initiative focuses on improving patient-doctor dialogue and fostering better understanding of medical conditions and treatment options. This collaboration seeks to address the need for more effective communication in healthcare.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-- %
Tags
none
-
Rhea-AI Summary
Verastem Oncology (VSTM) reported plans to submit an application for accelerated approval for Avutometinib and Defactinib in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) in H1 2024. They also presented additional patient subgroup data showing promising levels of response in LGSOC, regardless of prior therapies. The company entered into a collaboration with GenFleet Therapeutics and reported financial results for Q3 2023.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-5.66%
Tags
-
Rhea-AI Summary
Verastem Oncology (Nasdaq: VSTM) announced the results of the first-ever LGSOC Patient Impact Survey, revealing the challenges faced by people living with low-grade serous ovarian cancer. The survey was developed through a global collaboration among patient advocacy groups and medical leaders to address the urgent needs of patients. LGSOC is a rare, highly recurrent ovarian cancer associated with slow but persistent tumor growth and a high mortality rate, relatively resistant to chemotherapy, with limited treatment options available.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
6.65%
Tags
none
Rhea-AI Summary
Verastem Oncology announced results of a subgroup analysis of the Phase 2 RAMP 201 trial, showing the combination of avutometinib and defactinib demonstrated robust efficacy in recurrent low-grade serous ovarian cancer (LGSOC) regardless of prior therapies. The analysis revealed consistent objective response rates (ORRs) in patients who received 1-3 lines of therapy (45.5%) and ≥4 lines of therapy (44.4%). The combination yielded an ORR of 43.5% in patients who had poor response to their last prior treatment. Safety profiles were similar across subgroups, and adverse events were mostly mild to moderate. Verastem Oncology plans to file for accelerated approval with the FDA and initiate a Phase 3 confirmatory trial of avutometinib and defactinib in LGSOC.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-3.36%
Tags
none

FAQ

What is the current stock price of Verastem (VSTM)?

The current stock price of Verastem (VSTM) is $5.49 as of December 4, 2024.

What is the market cap of Verastem (VSTM)?

The market cap of Verastem (VSTM) is approximately 243.7M.

What does Verastem, Inc. specialize in?

Verastem, Inc. specializes in developing novel drugs that target cancer stem cells to treat various major cancers, including breast cancer.

What are some of Verastem's key projects?

Verastem is working on RAF/MEK and FAK inhibitors to treat cancer. They are also developing a combination therapy of avutometinib and defactinib for low-grade serous ovarian cancer.

Who are Verastem's partners?

One of Verastem's key partners is GenFleet Therapeutics, with whom they are collaborating to advance oncology programs targeting KRAS mutations.

What is GFH375?

GFH375 is an oral KRAS G12D inhibitor being developed in collaboration with GenFleet Therapeutics. It targets cancer cells with KRAS G12D mutations.

What makes Verastem's approach unique?

Verastem focuses on cancer stem cells, aiming to develop therapies that prevent tumor recurrence and metastasis, a major challenge in cancer treatment.

What are RAF/MEK and FAK inhibitors?

RAF/MEK and FAK inhibitors are drugs that target specific signaling pathways in cancer cells, hindering their growth and survival.

What types of cancer is Verastem targeting?

Verastem is targeting major cancers, including breast cancer, ovarian cancer, and those with KRAS mutations.

What recent achievements has Verastem made?

Verastem's combination therapy of avutometinib and defactinib has been granted breakthrough therapy designation for treating recurrent low-grade serous ovarian cancer.

How does Verastem's partnership with GenFleet Therapeutics benefit their research?

The partnership allows Verastem to leverage GenFleet's expertise in oncology to advance new therapies targeting KRAS mutations, enhancing their oncology pipeline.

Where can I find more information about Verastem, Inc.?

More information can be found on their official website: www.verastem.com.

Verastem, Inc.

Nasdaq:VSTM

VSTM Rankings

VSTM Stock Data

243.67M
41.24M
0.83%
59.93%
5.3%
Biotechnology
Pharmaceutical Preparations
Link
United States of America
NEEDHAM