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Viking Therapeutics, Inc. (NASDAQ: VKTX) is a clinical-stage biopharmaceutical company based in San Diego, specializing in the development of novel therapies for metabolic and endocrine disorders. Focused on creating first-in-class or best-in-class treatments, Viking's research leverages its deep expertise in metabolism to develop innovative therapeutics designed to improve patients' lives.
Viking's pipeline includes three main compounds currently in clinical trials. VK2809, a selective thyroid hormone receptor beta agonist, is being evaluated for the treatment of non-alcoholic steatohepatitis (NASH) and fibrosis. Recent data from a Phase 2b VOYAGE study showed that VK2809 achieved both its primary and secondary endpoints, demonstrating significant reductions in liver fat content and improvements in fibrosis and NASH resolution over a 52-week treatment period.
The company is also advancing VK2735, a dual agonist of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors, which is being developed for the treatment of metabolic disorders such as obesity. Phase 1 and 2 trials have indicated promising efficacy and safety profiles, with significant reductions in body weight observed in treated patients. Viking is evaluating both subcutaneous and oral formulations of VK2735, aiming to enhance patient convenience and expand market opportunities.
In the realm of rare diseases, Viking is developing VK0214, a selective thyroid hormone receptor beta agonist for the treatment of X-linked adrenoleukodystrophy (X-ALD). Currently in a Phase 1b clinical trial, VK0214 has shown potential benefits in treating the adrenomyeloneuropathy (AMN) form of X-ALD.
Financially, Viking reported a strong cash position of $963 million as of March 31, 2024, following a public offering of common stock. The company's strategic focus on advancing its clinical programs, coupled with its robust financial health, positions it well for future growth and development.
For more information, please visit Viking Therapeutics' website.
Viking Therapeutics (NASDAQ: VKTX) presented preclinical data on its novel dual amylin and calcitonin receptor agonists (DACRAs) at the 84th Scientific Sessions of the American Diabetes Association. The studies showcased significant reductions in body weight and food intake in healthy rats and diet-induced obese (DIO) mice, with improvements in key metabolic markers such as blood glucose levels.
Viking's DACRAs achieved up to 8% body weight reduction in lean rats 72 hours post a single dose, and up to 10% weight loss in DIO mice over 24 days. Additionally, a 24% reduction in blood glucose was observed in DIO mice after 24 days. The compounds demonstrated EC50 values ranging from low nM to micromolar on the human amylin 3 and calcitonin receptors. These results support the continued development of Viking's dual agonist program targeting obesity and metabolic diseases.
Viking Therapeutics has announced positive 52-week histologic data from its Phase 2b VOYAGE study of VK2809 in patients with biopsy-confirmed NASH. VK2809 demonstrated significant efficacy across key endpoints: up to 75% of treated patients achieved NASH resolution with no worsening of fibrosis, and up to 57% showed a ≥1-stage improvement in fibrosis without worsening of NASH. The safety profile was consistent with earlier results, with most adverse events being mild or moderate. The results also showed substantial reductions in liver fat content and plasma lipids, indicating potential cardio-protective benefits.
Viking Therapeutics (NASDAQ: VKTX), a clinical-stage biopharmaceutical company developing therapies for metabolic and endocrine disorders, announced participation in two upcoming investor conferences.
At the 2024 Jefferies Global Healthcare Conference, Viking will deliver a corporate presentation and engage in 1-on-1 meetings on June 5-6, 2024, at the Marriott Marquis, New York. The presentation is scheduled for June 6, 2024, from 10:30 to 10:55 a.m. Eastern.
Viking will also participate in 1-on-1 meetings at the Stifel 2nd European Healthcare Summit from June 25-27, 2024, at the InterContinental Lyon Hotel Dieu, Lyon, France.
A live webcast of the Jefferies presentation will be available on Viking’s website, with a replay accessible following the conference.
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