Welcome to our dedicated page for Verve Therapeutics news (Ticker: VERV), a resource for investors and traders seeking the latest updates and insights on Verve Therapeutics stock.
Verve Therapeutics, Inc. (Nasdaq: VERV) is a cutting-edge biotechnology company headquartered in Cambridge, Massachusetts. With a mission to protect the world from heart disease, Verve is pioneering a transformative approach in cardiovascular care. The company leverages two major breakthroughs in 21st-century biomedicine—human genetics analysis and gene editing—to create life-changing therapies for coronary heart disease.
Verve Therapeutics is focused on developing single-course gene editing medicines to permanently lower LDL cholesterol and triglyceride levels in adults, thereby reducing the risk of coronary heart disease. Their innovative treatments are designed to be administered once in a lifetime, offering a potential shift from chronic disease management to a one-time cure.
Founded by leading experts in cardiovascular medicine, human genetics, and gene editing, Verve has garnered substantial support from top-tier investors, including GV (formerly Google Ventures), Arch Venture Partners, and others. The company was recognized as a '2020 Best Places to Work' by the Boston Business Journal, highlighting its positive workplace culture and innovative environment.
Verve's flagship programs include VERVE-101, VERVE-102, and VERVE-201, each targeting genes validated for their role in lowering low-density lipoprotein cholesterol (LDL-C). Specifically, VERVE-101 and VERVE-102 aim to permanently deactivate the PCSK9 gene, initially targeting patients with heterozygous familial hypercholesterolemia (HeFH) and eventually expanding to treat patients with atherosclerotic cardiovascular disease (ASCVD) who have not reached LDL-C goals using traditional therapies. Meanwhile, VERVE-201 targets the ANGPTL3 gene, focusing on patients with homozygous familial hypercholesterolemia (HoFH) and refractory hypercholesterolemia.
Recent milestones for Verve Therapeutics include the first human proof-of-concept data for in vivo base editing from the ongoing heart-1 phase 1b clinical trial of VERVE-101. This study demonstrated dose-dependent reductions in disease-causing LDL-C in patients with HeFH. The company is also progressing with the heart-2 phase 1b clinical trial for VERVE-102 and plans to launch a phase 1b trial for VERVE-201 in the latter half of 2024.
In terms of financial performance, Verve maintains a solid cash position, with $624.0 million in cash and marketable securities as of December 31, 2023. This robust financial standing is augmented by strategic partnerships, including a significant collaboration with Eli Lilly, which involved a private placement and potential milestone payments up to $465 million.
Under the leadership of CEO Sekar Kathiresan, M.D., Verve is pushing the boundaries of cardiovascular disease treatment. The company's relentless commitment to scientific excellence and patient care positions it as a potential game-changer in the field of genetic medicine.
Verve Therapeutics has received clearance for its Clinical Trial Authorization (CTA) application from the UK Medicines and Healthcare products Regulatory Agency for VERVE-101, aimed at treating heterozygous familial hypercholesterolemia (HeFH). This achievement marks the second regulatory clearance for VERVE-101, which is currently in the heart-1 clinical trial in New Zealand and set to begin patient enrollment in the UK. The trial aims to assess the safety and tolerability of VERVE-101 and gather interim clinical data in 2023, showcasing Verve's commitment to innovating cardiovascular disease care.
Verve Therapeutics has announced new preclinical data for its gene editing candidate, VERVE-201, aimed at treating homozygous familial hypercholesterolemia and atherosclerotic cardiovascular disease. This candidate targets the ANGPTL3 gene in the liver, significantly impacting cholesterol metabolism. Promising results showed potent, on-target editing in human liver cells and substantial reductions in ANGPTL3 protein levels in non-human primates. The company plans to present this data at the European Society of Cardiology 2022 Congress on August 29, 2022, and anticipates moving towards clinical trials in 2024.
Verve Therapeutics reported significant advancements, including over $300 million added to its balance sheet, supporting operations well into the second half of 2025.
VERVE-101, aimed at treating heterozygous familial hypercholesterolemia, initiated patient dosing with interim clinical data expected in 2023. Regulatory clearances in the UK and US are anticipated soon.
The company also nominated VERVE-201 for ANGPTL3 treatment, with upcoming data presentations and IND-enabling studies in the pipeline. Additionally, new board members were appointed to bolster strategic growth.
Verve Therapeutics (Nasdaq: VERV) has successfully closed an upsized public offering of 9,583,334 shares at $27.00 per share, generating gross proceeds of $258.8 million. The offering's total includes 1,250,000 shares from underwriters' exercised options. Shares were sold under a shelf registration statement approved by the SEC. This financing aims to advance Verve's gene editing therapies targeting cardiovascular disease.
Verve Therapeutics, Inc. (Nasdaq: VERV) announced an upsized underwritten public offering of 8,333,334 shares of its common stock priced at $27.00 each, aiming for approximately $225 million in gross proceeds. The offering, fully underwritten, is set to close on July 25, 2022, subject to customary conditions. Additionally, underwriters may purchase up to 1,250,000 additional shares. Verve plans to utilize the funds to advance its gene editing therapies targeting cardiovascular disease, particularly focusing on PCSK9 and ANGPTL3.
Verve Therapeutics (Nasdaq: VERV) has initiated an underwritten public offering of $200 million in common stock. The offering includes an option for underwriters to purchase up to an additional 15% of the shares, subject to market conditions. The company is leveraging a shelf registration statement effective as of July 12, 2022. This offering aims to support Verve's innovative approach to addressing cardiovascular disease through single-course gene editing, targeting genes like PCSK9 and ANGPTL3.
Verve Therapeutics has announced a collaboration with Vertex Pharmaceuticals, securing a $60 million upfront payment, which includes a $35 million equity investment. The partnership aims to develop an in vivo gene editing program targeting a specific liver disease over four years. Vertex will finance the research, while retaining rights to future development and commercialization. Verve could also earn up to $406 million in milestone payments and royalties on potential net sales. This collaboration marks a pivotal step in Verve's ongoing efforts to innovate gene editing therapies for cardiovascular diseases.
Verve Therapeutics announces the start of the Phase 1b clinical trial, heart-1, for its investigational gene editing medicine, VERVE-101, aimed at treating patients with heterozygous familial hypercholesterolemia (HeFH). The first patient has been dosed, marking a significant milestone in its development. VERVE-101 seeks to permanently deactivate the PCSK9 gene in the liver to reduce low-density lipoprotein cholesterol (LDL-C) levels. The trial plans to enroll around 40 participants, with interim data expected in 2023.
Verve Therapeutics has appointed Alexander G. “Bo” Cumbo, former CEO of AavantiBio, to its board of directors. Cumbo, who has over 28 years of experience in the pharmaceutical industry, brings a wealth of expertise in drug development and commercial execution. His appointment comes as Verve advances its regulatory strategy for VERVE-101 and its second program targeting ANGPTL3. The company aims to transform cardiovascular disease treatment from chronic management to single-course therapies, with VERVE-101 targeting familial hypercholesterolemia.
Verve Therapeutics will showcase its innovative approach to treating cardiovascular disease at the 2022 Jefferies Healthcare Conference. Co-founder and CEO Sekar Kathiresan will speak on June 8, 2022, at 1:00 p.m. ET in NYC. The company focuses on single-course gene editing medicines, specifically targeting PCSK9 and ANGPTL3 genes to lower LDL cholesterol levels. Verve’s lead candidate, VERVE-101, aims to reduce cardiovascular risk by permanently turning off the PCSK9 gene in the liver. A live webcast will be available on their investor website and archived for 60 days.
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