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VectivBio AG is a clinical-stage biotechnology company dedicated to developing innovative treatments for rare diseases. Established in 2019 as a spinout from Therachon, which was acquired by Pfizer, Inc., VectivBio focuses on leveraging well-defined biology to create transformational therapeutics.
Core Business: VectivBio's mission is to bring groundbreaking treatments to patients with rare and severe conditions. The company is currently advancing its lead program for short bowel syndrome, a debilitating condition that affects nutrient absorption in the intestines. This program is a testament to VectivBio's commitment to addressing unmet medical needs.
Leadership and Expertise: The company is led by a world-class team with extensive experience in rare diseases, research and development, commercialization, and business development. This leadership is crucial in driving the company's mission forward and ensuring successful outcomes for their programs.
Recent Achievements and Partnerships: Since its inception, VectivBio has made significant strides in its research and development efforts. The company continues to build a portfolio of medicines targeting rare diseases, drawing on the expertise of its founders and leveraging strategic partnerships to accelerate progress.
Financial Health: VectivBio's financial condition is robust, backed by solid funding and strategic investments that enable it to pursue its ambitious research and development goals.
Innovation and Impact: VectivBio’s work is not just about developing new treatments; it’s about making a profound impact on the lives of patients with rare diseases. The company’s focus on short bowel syndrome and other orphan conditions underscores its dedication to transforming patient care through science and innovation.
VectivBio Holding AG (Nasdaq: VECT) has announced its 2022 Annual General Meeting will take place on June 30, 2022, in Basel, Switzerland, at 2:00 p.m. CEST. Due to the COVID-19 pandemic, shareholders will not attend in person and must be represented via an independent proxy. VectivBio is focused on developing innovative treatments for severe rare conditions, including gastrointestinal diseases and inherited metabolic diseases, through its lead product candidate apraglutide and the CoMET platform.
VectivBio announced the dosing of two patients in the STARGAZE Phase 2 clinical trial for apraglutide, targeting steroid-refractory gastrointestinal acute Graft-versus-Host Disease (aGvHD). This first-in-class therapy offers a regenerative approach to aGvHD, a severe condition post-hematopoietic stem cell transplant. Apraglutide's potential is highlighted by preclinical data suggesting it may protect the GI tract and improve patient outcomes. Interim data is expected in H1 2023, with the trial designed for rapid adaptation to pivotal studies if successful.
VectivBio Holding AG (Nasdaq: VECT) announced that CEO Luca Santarelli will participate in a fireside chat during the Bank of America 2022 Healthcare Conference on May 11, 2022, at 4:40 p.m. PT (7:40 p.m. ET). The event will be held in Las Vegas, NV, and VectivBio's management will also engage in one-on-one meetings with investors. A webcast of the chat will be available for 30 days post-event on the company’s website. VectivBio is focused on developing treatments for severe rare conditions, with its lead candidate apraglutide in a Phase 3 trial for short bowel syndrome.
VectivBio Appoints New Senior VP
VectivBio Holding AG has appointed Patrick Malloy as Senior Vice President, Investor Relations and Strategic Communications. With over 20 years of experience, including roles at Arena Pharmaceuticals and Actelion, Malloy will enhance VectivBio's investor engagement as the company advances its lead candidate, apraglutide, in clinical trials for short bowel syndrome. This strategic move aims to elevate VectivBio's profile among investors and stakeholders as the company prepares for significant upcoming catalysts in the biopharmaceutical space.
VectivBio Holding AG (Nasdaq: VECT) reported significant progress in its clinical programs and financial results for 2021. The company is advancing its STARS Phase 3 program for apraglutide, targeting topline results by the end of 2023. A licensing agreement with Asahi Kasei Pharma provides $30 million upfront, plus potential milestones of $170 million. VectivBio's cash position stands at $102.7 million, supported by a $75 million credit facility. Management anticipates a strong financial runway to support clinical trials through 2023.
VectivBio has secured an exclusive licensing agreement with Asahi Kasei Pharma for the development and commercialization of apraglutide in Japan, featuring a $30 million upfront payment and potential milestones of $170 million. Additionally, the company established a $75 million flexible loan facility with Kreos Capital. Together, these agreements enhance VectivBio’s financial stability and support the advancement of apraglutide as a treatment for severe gastrointestinal conditions. The company reported cash and equivalents of $103 million as of December 31, 2021.
VectivBio presents promising data on apraglutide, showcasing its effectiveness in treating short bowel syndrome with intestinal failure (SBS-IF) in patients with renal impairment. Presented at the 2022 ASPEN conference, the data indicates apraglutide's tolerance and its capacity to treat up to 28% of SBS-IF patients underserved by current therapies. Unlike existing GLP-2 treatments, apraglutide does not need dose adjustments for patients with severe renal issues. The company anticipates releasing Phase 3 trial results in the second half of 2023, emphasizing apraglutide's potential to improve patient outcomes.
VectivBio announced promising preclinical results for apraglutide, a GLP-2 analog, demonstrating its ability to shield against chemotherapy-induced gastrointestinal damage and enhance survival rates in mouse models of gastrointestinal acute graft-versus-host disease (aGVHD). This data supports the regenerative treatment hypothesis, leading to the initiation of the Phase 2 STARGAZE clinical study in steroid-refractory aGVHD after receiving FDA clearance for its IND application. Upcoming interim data from this study is anticipated later this year.
VectivBio Holding AG (Nasdaq: VECT) will have its CEO, Luca Santarelli, participate in a virtual fireside chat at the SVB Leerink 11th Annual Global Healthcare Conference on February 17, 2022, at 1:40 p.m. ET. This event will include one-on-one investor meetings and a live webcast available on the company's website. VectivBio is focused on developing treatments for severe rare conditions, with its lead drug, apraglutide, in Phase 3 trials for short bowel syndrome. The company also addresses inherited metabolic diseases in pediatric populations through its CoMET platform.
VectivBio Holding AG (Nasdaq: VECT) reported significant progress in its Q3 2021 business update. The FDA cleared the IND for apraglutide for aGVHD, with the first patient expected in Q1 2022. The pivotal STARS program for SBS-IF is advancing, with most sites activated and interim results anticipated in 1H 2022. Additionally, VectivBio expanded its pipeline by acquiring CoMET, adding four new R&D programs aimed at treating inherited metabolic diseases. These developments solidify VectivBio's commitment to transforming the treatment landscape for rare conditions.
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