Welcome to our dedicated page for Unity Biotechnology news (Ticker: UBX), a resource for investors and traders seeking the latest updates and insights on Unity Biotechnology stock.
Unity Biotechnology, Inc. (NASDAQ: UBX) is a leading biotechnology company focused on developing innovative therapeutics aimed at extending human healthspan by targeting age-related diseases. The company's pioneering approach centers on creating senolytic medicines, which selectively eliminate senescent cells – cells that contribute to aging and various diseases. Unity's initial efforts are directed toward treating conditions such as osteoporosis, eye diseases, and pulmonary diseases.
Unity’s main drug candidates include:
- UBX1325: A promising treatment for age-related eye diseases, including diabetic macular edema (DME). UBX1325 recently demonstrated positive results in the Phase 2 ENVISION study, maintaining vision gains and significantly reducing anti-VEGF treatment needs in patients with wet AMD.
- UBX2089: A circulating hormone being studied for multiple neurological conditions.
- UBX2050: Another investigational drug aimed at age-associated diseases.
Recently, Unity announced the successful results from Part B of the Phase 2 ENVISION study for UBX1325, highlighting its safety and efficacy in maintaining visual acuity and reducing the treatment burden for patients with wet AMD who were not receiving optimal benefits from ongoing anti-VEGF therapy. The study showed that 40% of UBX1325-treated patients did not require anti-VEGF rescue through 48 weeks.
Unity's current focus is on its DME program, where UBX1325 showed a statistically significant improvement in visual acuity during the Phase 2 BEHOLD study. The company has initiated a Phase 2b study and plans to randomize the first patient in Q4 2023. Additional data from the ENVISION study is expected to be presented at upcoming medical conferences.
About the ENVISION Study: The Phase 2 ENVISION study is a multi-center, randomized, double-masked, active-controlled study evaluating the safety, tolerability, efficacy, and durability of UBX1325 in combination with aflibercept for patients with neovascular AMD.
For more detailed information, visit www.unitybiotechnology.com.
UNITY Biotechnology announced positive results from the Phase 2 BEHOLD study of UBX1325, an investigational treatment for diabetic macular edema (DME). A single injection led to a statistically significant improvement in Best Corrected Visual Acuity (BCVA) of +6.2 ETDRS letters over 48 weeks. Approximately 53% of treated patients did not require additional injections during this period. Additionally, retinal structure remained stable as measured by central subfield thickness (CST). The treatment exhibited a favorable safety profile, with no intraocular inflammation observed. UNITY plans to advance to a Phase 2b DME study against aflibercept in the second half of 2023.
UNITY Biotechnology Program Update
UNITY Biotechnology (NASDAQ: UBX) is scheduled to host a program update on its lead program, UBX1325, focused on diseases of aging. The update will feature retinal expert Robert B. Bhisitkul, M.D., Ph.D. from UCSF, and will take place on April 24, 2023, at 5:00 a.m. PT/8:00 a.m. ET. The discussion is expected to cover potential therapeutic advancements in age-related ophthalmologic conditions, such as Diabetic Macular Edema (DME) and Age-related Macular Degeneration (AMD).
Investors can access the live webcast on UNITY's website, with a replay available shortly after. The company emphasizes its dedication to developing therapeutics aimed at selectively eliminating or modulating senescent cells to address age-related diseases. However, investors should remain cautious of the inherent risks and uncertainties in the clinical development process.
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