Twist Bioscience Unveils Differentiated Ultra High-Throughput Library Preparation Solution at AGBT
- Twist Bioscience Corporation announced the early access of the Twist Flex Prep Ultra High-Throughput (UHT) Kit, aiming to enable unparalleled throughput at a fraction of the cost of existing on-market solutions.
- The kit utilizes novel chemistry that accepts and self-normalizes a wide range of sample input amounts through a new proprietary Normalization By Ligation (NBL) technology, crucial for researchers in AgBio who sequence thousands of samples of varying inputs.
- The technology is positioned to drive NGS adoption in agricultural genomics, enabling streamlined, scalable, and cost-effective workflows for high-throughput applications in breeding, trait selection, and other research areas.
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Insights
The introduction of the Twist Flex Prep Ultra High-Throughput (UHT) Kit by Twist Bioscience represents a significant advancement in the field of agricultural genomics. The kit's proprietary Normalization By Ligation (NBL) technology is a game-changer for researchers, as it simplifies the preparation of large-scale sample sets by eliminating manual normalization, which is both labor-intensive and costly. The cost savings and increased efficiency could catalyze a shift from microarray-based workflows to next-generation sequencing (NGS), potentially increasing the company's market share in this segment.
Moreover, the ability to pool up to 48 samples with unique adapters and the compatibility with high-throughput Unique Dual Indexing (UDI) system, theoretically allowing for over 140,000 multiplexed samples, is particularly impressive. This level of multiplexing could lead to economies of scale that were previously unattainable, reducing the cost per sample and making large-scale genomic studies more feasible. Investors should note that the adoption of such technologies in AgBio can drive long-term growth for Twist Bioscience, as the agricultural industry continues to embrace genomic tools for crop improvement and trait selection.
The strategic positioning of the Twist Flex Prep UHT Kit in the agricultural genomics market is indicative of Twist Bioscience's commitment to addressing the high-throughput needs of this sector. The technology's unveiling at the AGBT General Meeting signals the company's intention to engage with industry leaders and showcase its innovative solutions. The market for agricultural genomics is expanding as the demand for sustainable crop production and enhanced breeding techniques grows. The introduction of cost-effective and scalable NGS workflows could lead Twist to capture a larger slice of this burgeoning market.
From a market perspective, the timing of this technology release is crucial. With the increasing competition in the NGS space, early access to such technologies can provide a competitive edge and establish Twist Bioscience as a key player in the AgBio sector. The potential reduction in plastic waste and reagent volume also aligns with the growing trend of environmental sustainability in research, which may resonate with the values of modern consumers and investors alike.
The application of Twist Flex Prep UHT Kit in agricultural genomics could have profound implications for the industry. The ability to conduct high-throughput sequencing at reduced costs aligns with the sector's need for rapid and efficient analysis of genetic information to accelerate breeding programs and trait selection. This technology facilitates a more streamlined workflow, which is vital for the large sample sizes typically associated with agricultural studies. As the industry moves towards more data-driven decision-making, the ease of integration with existing automation systems is a critical factor that could influence the rate of adoption among AgBio researchers.
Furthermore, the environmental aspect of reducing plastic waste is not only a cost-saving measure but also an ethical consideration that is increasingly important in the scientific community. The kit's design, which minimizes the use of consumables, could appeal to institutions that prioritize sustainable practices, potentially opening up additional market segments for Twist Bioscience.
Early access of novel technology that enables preparation of thousands of samples at low cost through self-normalization, enhanced multiplexing, and streamlined workflow
Innovative solution positioned to drive NGS adoption in AgBio
Twist Flex Prep UHT Kit and additional NGS tools to be highlighted at AGBT General Meeting
Built upon enzymatic fragmentation library preparation, the Twist Flex Prep UHT Kit utilizes novel chemistry that accepts and self-normalizes a wide range of sample input amounts through a new proprietary Normalization By Ligation (NBL) technology. This is crucial for researchers in AgBio who sequence thousands of samples of varying inputs and removes the need to manually normalize each one, saving significant time and costs. The kit also enables enhanced multiplexing by pooling samples early in the workflow so that researchers can process more samples without additional capital investment. The enhanced multiplexing further limits hands on time and saves researchers costs of reagents in downstream purification and indexing steps. In addition, pooling samples significantly reduces cost and plastic waste from pipette tips and plates in high-throughput labs.
“In agricultural genomics, researchers often test thousands of samples at once, relying heavily on automation to support large scale testing. Many researchers continue to perform traditional microarray based workflows, as overall higher cost per sample for NGS based workflow has hindered adoption,” said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “With the technology early access of our Twist Flex Prep UHT Kit, researchers will soon have access to a scalable, streamlined, and most importantly, cost effective NGS workflows for their various samples and research areas, and overcome the challenges that have caused slow adoption of NGS in the AgBio space. This ultra high-throughput solution could enable them to push new boundaries in breeding, trait selection, and other high-throughput applications, with high data quality while saving costs.”
Twist Flex Prep UHT Kit Workflow
The Twist Flex Prep UHT Kit workflow is purpose-built to streamline and massively scale up Twist’s established enzymatic fragmentation methods. The new NBL technology eliminates the need to measure quantity of each DNA sample and to perform time consuming concentration adjustment prior to library preparation, saving significant cost per sample. Following fragmentation and adapter ligation of each sample in a plate, up to 48 samples are pooled together in a single tube. This pooling strategy results in a meaningful reduction in both volumes and costs of reagents required for subsequent beads purification and amplification steps. Libraries prepared from this kit can be leveraged to perform standard whole genome sequencing (WGS), target enrichment, or low-pass WGS with enrichment.
By combining up to 48 unique adapters from the Twist UHT Flex Prep Kit with Twist’s current high throughput Unique Dual Indexing (UDI) system, theoretical sample multiplexing can top more than 140,000. All plate and tube formats are optimized to ensure compatibility with key automation systems, a critical consideration for labs looking to streamline workflows and reduce hands-on time.
Presence at Advances in Genome Biology and Technology (AGBT) General Meeting
Twist will highlight its NGS tools in posters and presentations at the AGBT General Meeting taking place in
Poster: Twist Pan-Cancer Reference Standards V2: Enhanced Precision and Reduced Errors in ctDNA Analysis
Time: Tuesday, February 6, 1:30-3:30 PM ET
Presentation: Unveiling Next-Gen Solutions for Precision Diagnostics and Beyond
Speaker: Emily M. Leproust, CEO and co-founder of Twist Bioscience
Time: Wednesday, February 7, 3:00-3:20 PM PT
Location: Palms Ballroom 2 & 3
Poster: Development of a high-throughput NGS library preparation workflow with normalization adapters and in-line barcode technology
Time: Wednesday, February 7, 4:45-6:10 PM ET
About Twist Bioscience Corporation
Twist Bioscience is a leading and rapidly growing synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. Twist is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next-generation sequencing (NGS) preparation, and antibody libraries for drug discovery and development. Twist is also pursuing longer-term opportunities in digital data storage in DNA and biologics drug discovery. Twist makes products for use across many industries including healthcare, industrial chemicals, agriculture and academic research.
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Twist Bioscience Legal Notice Regarding Forward-Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical facts contained herein are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the ability of the Twist Flex Prep UHT Kit to enable unparalleled throughput at a fraction of the cost of existing on market solutions, save researchers significant time and costs, and enable them to push new boundaries in breeding, trait selection, and other high-throughput applications. Forward-looking statements involve known and unknown risks, uncertainties, and other important factors that may cause Twist Bioscience’s actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the ability to achieve the expected benefits of Twist Bioscience’s restructuring activities and reduced investments in DNA data storage; the ability to attract new customers and retain and grow sales from existing customers; the ability of Twist Bioscience to achieve sufficient revenue to achieve or maintain positive cash flow from operations or profitability in any given period; risks and uncertainties of rapidly changing technologies and extensive competition in synthetic biology that could make the products Twist Bioscience is developing obsolete or non-competitive; uncertainties of the retention of significant customers; the ability of Twist Bioscience to successfully integrate acquired companies and to achieve expected benefits from acquisitions; supply chain and other disruptions; risks of third party claims alleging infringement of patents and proprietary rights or seeking to invalidate Twist Bioscience’s patents or proprietary rights; and the risk that Twist Bioscience’s proprietary rights may be insufficient to protect its technologies. For a description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Twist Bioscience’s business in general, see Twist Bioscience’s risk factors set forth in Twist Bioscience’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on February 2, 2024 and subsequent filings with the SEC. Any forward-looking statements contained in this press release speak only as of the date hereof, and Twist Bioscience specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.
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