Telix and Eckert & Ziegler to Partner on Actinium-225 Production Technology
Telix Pharmaceuticals has partnered with Eckert & Ziegler SE for cyclotron-based production of actinium-225, a key isotope for targeted alpha therapies (TATs). The collaboration combines EZAG's isotope technology with Telix's global manufacturing network to enhance production capacity for both development and commercial purposes. Alpha emitters like actinium-225 can deliver concentrated energy to cancer tissue while minimizing damage to surrounding healthy cells. Telix's TAT pipeline includes several clinical-stage candidates: TLX592 for prostate cancer, TLX252 for CAIX-targeting, TLX101 for brain cancer, and TLX300 for soft tissue sarcoma.
Telix Pharmaceuticals ha stretto una partnership con Eckert & Ziegler SE per la produzione di actinio-225 basata su ciclotrone, un isotopo chiave per le terapie a emissione alfa mirate (TAT). La collaborazione unisce la tecnologia isotopica di EZAG con la rete di produzione globale di Telix, al fine di potenziare la capacità produttiva per scopi sia di sviluppo che commerciali. Gli emettitori alfa come l'actinio-225 possono fornire energia concentrata ai tessuti cancerosi, minimizzando al contempo i danni alle cellule sane circostanti. Il pipeline TAT di Telix include diversi candidati in fase clinica: TLX592 per il cancro alla prostata, TLX252 per il targeting del CAIX, TLX101 per il cancro al cervello e TLX300 per il sarcoma dei tessuti molli.
Telix Pharmaceuticals se ha asociado con Eckert & Ziegler SE para la producción de actinio-225 basada en ciclotrones, un isótopo clave para las terapias de emisión alfa dirigidas (TAT). La colaboración combina la tecnología isotópica de EZAG con la red de fabricación global de Telix para mejorar la capacidad de producción tanto para fines de desarrollo como comerciales. Los emissores alfa como el actinio-225 pueden entregar energía concentrada al tejido canceroso mientras minimizan los daños a las células sanas circundantes. El pipeline de TAT de Telix incluye varios candidatos en etapa clínica: TLX592 para el cáncer de próstata, TLX252 para la dirección de CAIX, TLX101 para el cáncer cerebral y TLX300 para el sarcoma de tejidos blandos.
Telix Pharmaceuticals는 Eckert & Ziegler SE와 협력하여 사이클로트론 기반의 액티늄-225 생산을 진행하고 있습니다. 액티늄-225는 표적 알파 치료(TAT)에 중요한 동위 원소입니다. 이 협력은 EZAG의 동위 원소 기술과 Telix의 글로벌 제조 네트워크를 결합하여 개발 및 상업적 목적으로 생산 능력을 강화하는 것을 목표로 하고 있습니다. 알파 방사체인 액티늄-225는 암 조직에 집중된 에너지를 제공하면서 주변 건강한 세포에 대한 손상을 최소화할 수 있습니다. Telix의 TAT 파이프라인에는 여러 임상 단계 후보가 포함되어 있습니다: 전립선암을 위한 TLX592, CAIX 표적을 위한 TLX252, 뇌암을 위한 TLX101, 연조직 육종을 위한 TLX300입니다.
Telix Pharmaceuticals a établi un partenariat avec Eckert & Ziegler SE pour la production d'actinium-225 basée sur les cyclotrons, un isotope clé pour les thérapies ciblées à émission alpha (TAT). Cette collaboration combine la technologie isotopique d'EZAG avec le réseau de fabrication mondial de Telix pour améliorer la capacité de production tant pour le développement que pour des fins commerciales. Les émetteurs alpha comme l'actinium-225 peuvent délivrer une énergie concentrée aux tissus cancéreux tout en minimisant les dommages aux cellules saines environnantes. Le pipeline TAT de Telix comprend plusieurs candidats en phase clinique : TLX592 pour le cancer de la prostate, TLX252 pour le ciblage CAIX, TLX101 pour le cancer du cerveau et TLX300 pour le sarcome des tissus mous.
Telix Pharmaceuticals hat eine Partnerschaft mit Eckert & Ziegler SE für die cyclotronbasierte Produktion von Actinium-225 gegründet, einem SchlüssIsootop für gezielte Alpha-Therapien (TAT). Die Zusammenarbeit verbindet die Isotoptechnologie von EZAG mit dem globalen Produktionsnetzwerk von Telix, um die Produktionskapazität sowohl für Entwicklungs- als auch für kommerzielle Zwecke zu verbessern. Alpha-Emittenten wie Actinium-225 können konzentrierte Energie an Krebsgewebe liefern und gleichzeitig Schäden an umgebenden gesunden Zellen minimieren. Die TAT-Pipeline von Telix umfasst mehrere klinische Kandidaten: TLX592 für Prostatakrebs, TLX252 für CAIX-Zielgruppen, TLX101 für Hirntumoren und TLX300 für Weichgewebesarkome.
- Strategic partnership secures additional commercial source of actinium-225
- Access to scalable isotope production technology
- Leverages existing global manufacturing infrastructure
- Expands capabilities in targeted alpha therapy development
- None.
Insights
This strategic partnership between Telix and EZAG marks a significant advancement in targeted alpha therapy development. The collaboration addresses a critical supply chain challenge in producing actinium-225, a highly sought-after isotope for next-generation cancer treatments. The agreement leverages EZAG's cyclotron technology with Telix's global manufacturing infrastructure, potentially solving scalability issues that have historically alpha therapy development.
Telix's extensive TAT pipeline, including four clinical-stage programs targeting various cancers, positions them well to capitalize on this technology. The combination of alpha emitters' precision (short-range, high-energy delivery) with Telix's targeting mechanisms could yield more effective cancer treatments with reduced side effects compared to traditional beta-emitter therapies.
This deal strengthens Telix's competitive position in the rapidly growing radiopharmaceutical market, particularly as industry forecasts suggest substantial growth in actinium-225 demand over the next decade.
This partnership significantly enhances Telix's market positioning in the emerging targeted alpha therapy space. The collaboration provides both immediate commercial access to actinium-225 and long-term production capabilities, creating a vertical integration advantage. The strategic value lies in securing a reliable supply chain for a critical resource in an industry where isotope availability often constrains development and commercialization.
The deal's timing is particularly strategic as the radiopharmaceutical market experiences rapid growth and increasing competition. By partnering with EZAG, a leading global isotope technology provider, Telix gains a competitive edge in scaling production to meet both research needs and future commercial demand. This positions Telix favorably against competitors who may face supply constraints in actinium-225 access.
MELBOURNE, Australia and BERLIN, Nov. 13, 2024 (GLOBE NEWSWIRE) -- Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces that it has entered into a technology collaboration and licence agreement with Berlin-based Eckert & Ziegler SE (EZAG) for the use of EZAG’s cyclotron-based systems to produce the alpha-emitting isotope, actinium-225 (225Ac). This provides Telix with both an additional commercial source of 225Ac and access to a platform technology that enables highly efficient, scalable isotope production for use in the development of next generation targeted alpha therapies (TATs), a strategic focus for Telix.
EZAG is one of the world’s largest providers of isotope technology for medical, scientific and industrial use and a long-term partner of Telix. By combining EZAG’s technology with Telix’s rapidly expanding global manufacturing footprint, the collaboration will enhance capacity to produce 225Ac, to accelerate the development of Telix’s alpha therapy candidates and support eventual commercial demand.
“This new collaboration is a significant step in the implementation of our actinium strategy,” said Dr. Harald Hasselmann, Chief Executive Officer of Eckert & Ziegler. “Eckert & Ziegler and Telix have a long-standing and multi-faceted business relationship. Combining the strengths of two leading players in radiopharmaceuticals and isotopes will create a collaboration for the supply of actinium-225-based radiotherapeutics, that are of high interest worldwide.”
Raphaël Ortiz, Chief Executive Officer, Telix International, added: “Targeted alpha therapy is regarded as the next frontier in the field of radiopharmaceuticals and is a priority R&D focus for Telix. This collaboration will enable us to unlock the early investment we have made in alpha therapy candidates and further leverage our manufacturing facilities worldwide, including in Brussels South, for the production of this important alpha emitting isotope.”
Alpha emitters such as 225Ac have the potential to deliver high amounts of energy to cancer tissue, while their short range can reduce the risk of damage to surrounding healthy cells, increasing the selectivity and potency of radiation treatment. In contrast, beta emitters such as lutetium-177 (177Lu) and iodine-131 (131I) have a longer penetration, which may suit bulky metastatic disease. The development of TATs is a priority research and development focus area for Telix and is highly complementary to the Company’s existing late-stage therapeutic pipeline. Experts believe the demand for 225Ac will increase significantly over the next decade.
Telix’s R&D commitment to TAT is demonstrated in an extensive clinical-stage TAT pipeline:
- TLX592, a PSMA1-targeting prostate cancer therapy candidate based on the Company’s proprietary RADmAb® engineered antibody technology;
- TLX252, a CAIX2-targeting radio antibody-drug conjugate (rADC) under development as a potential complement to the TLX250 (beta) program;
- TLX1023, a LAT14-targeting small molecule-based candidate under development as a potential complement to the TLX101 and TLX101-CDx brain cancer programs; and
- TLX300, a radiolabelled form of a naked antibody in-licensed from Eli Lilly & Company under investigation in soft tissue sarcoma5.
In addition, the completed OPALESCENCE6 and PERTINENCE7 investigator-initiated trials have demonstrated CAIX-targeting and dosimetry proof-of-concept for alpha therapy in triple-negative breast cancer, and non-muscle-invasive bladder cancer, respectively, using TLX250-CDx PET8.
About Eckert & Ziegler SE
Eckert & Ziegler SE, with more than 1,000 employees, is a leading specialist in isotope-related components for nuclear medicine and radiation therapy. The company offers a broad range of services and products for the radiopharmaceutical industry, from early development work to contract manufacturing and distribution. Eckert & Ziegler shares (ISIN DE0005659700) are listed in the TecDAX index of Deutsche Börse. For more information visit: www.ezag.com
Contributing to saving lives.
About Telix Pharmaceuticals Limited
Telix is a biopharmaceutical company focused on the development and commercialization of therapeutic and diagnostic radiopharmaceuticals and associated medical devices. Telix is headquartered in Melbourne, Australia, with international operations in the United States, Europe (Belgium and Switzerland), and Japan. Telix is developing a portfolio of clinical and commercial stage products that aims to address significant unmet medical needs in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX).
Telix’s lead imaging product, gallium-68 (68Ga) gozetotide injection (also known as 68Ga PSMA-11 and marketed under the brand name Illuccix®), has been approved by the U.S. Food and Drug Administration (FDA)9, by the Australian Therapeutic Goods Administration (TGA) 10, and by Health Canada11. No other Telix product has received a marketing authorization in any jurisdiction.
Visit www.telixpharma.com for further information about Telix, including details of the latest share price, announcements made to the ASX, investor and analyst presentations, news releases, event details and other publications that may be of interest. You can also follow Telix on X and LinkedIn.
Telix Investor Relations
Ms. Kyahn Williamson
Telix Pharmaceuticals Limited
SVP Investor Relations and Corporate Communications
Email: kyahn.williamson@telixpharma.com
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©2024 Telix Pharmaceuticals Limited. The Telix Pharmaceuticals® and Illuccix® names and logos are trademarks of Telix Pharmaceuticals Limited and its affiliates – all rights reserved.
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1 Prostate-specific membrane antigen.
2 Carbonic anhydrase IX.
3 TLX102 labelled with astatine-211. All other listed alpha therapies labelled with actinium-225.
4 Large amino acid transporter 1.
5 Telix ASX disclosure 17 April 2023.
6 ClinicalTrials.gov ID NCT04758780. Positive topline results presented at SABCS in December 2023, Telix media release 7 December 2023.
7 ClinicalTrials.gov ID NCT04897763.
8 Positron emission tomography.
9 Telix ASX disclosure 20 December 2021.
10 Telix ASX disclosure 2 November 2021.
11 Telix ASX disclosure 14 October 2022.
FAQ
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