Telomir Pharmaceuticals Confirms Lifespan Restoration and Normalization of Accelerated Aging in Preclinical Model of Progeria (A Rare Genetic Disorder Causing Rapid Aging)
Telomir Pharmaceuticals (NASDAQ:TELO) announced breakthrough findings from a preclinical progeria lifespan study conducted with Nagi Bioscience SA. The study, using C. elegans models with wrn-1 gene mutation, demonstrated that Telomir-1 effectively restored lifespan and normalized accelerated aging effects to levels comparable with normal specimens.
The research focused on treating Progeria, a rare genetic condition affecting fewer than 400 children worldwide, causing rapid aging and premature death. Telomir-1, a novel small molecule, works by controlling excess metal activity, reducing oxidative stress, preventing ferroptosis, lowering inflammation, and regulating telomere shortening processes.
The company has demonstrated Telomir-1's therapeutic potential across multiple areas, including type 2 diabetes reversal and Wilson's disease treatment. Following these positive results, Telomir plans to initiate in vitro studies using human progeria cell lines to further validate the treatment's effectiveness.
Telomir Pharmaceuticals (NASDAQ:TELO) ha annunciato risultati innovativi da uno studio preclinico sulla durata della vita dei pazienti affetti da progeria, condotto con Nagi Bioscience SA. Lo studio, utilizzando modelli di C. elegans con mutazione del gene wrn-1, ha dimostrato che Telomir-1 ha effettivamente ripristinato la durata della vita e normalizzato gli effetti dell'invecchiamento accelerato a livelli comparabili con esemplari normali.
La ricerca si è concentrata sul trattamento della progeria, una rara condizione genetica che colpisce meno di 400 bambini in tutto il mondo, causando un invecchiamento rapido e una morte prematura. Telomir-1, una nuova piccola molecola, agisce controllando l'attività eccessiva dei metalli, riducendo lo stress ossidativo, prevenendo la ferroptosi, abbassando l'infiammazione e regolando i processi di accorciamento dei telomeri.
L'azienda ha dimostrato il potenziale terapeutico di Telomir-1 in diverse aree, inclusi la reversibilità del diabete di tipo 2 e il trattamento della malattia di Wilson. A seguito di questi risultati positivi, Telomir prevede di avviare studi in vitro utilizzando linee cellulari umane di progeria per convalidare ulteriormente l'efficacia del trattamento.
Telomir Pharmaceuticals (NASDAQ:TELO) anunció descubrimientos innovadores de un estudio preclínico sobre la duración de la vida de pacientes con progeria, realizado junto a Nagi Bioscience SA. El estudio, utilizando modelos de C. elegans con mutación del gen wrn-1, demostró que Telomir-1 restauró efectivamente la duración de la vida y normalizó los efectos del envejecimiento acelerado a niveles comparables con especímenes normales.
La investigación se centró en tratar la progeria, una rara condición genética que afecta a menos de 400 niños en todo el mundo, causando un envejecimiento rápido y muerte prematura. Telomir-1, una nueva pequeña molécula, funciona controlando la actividad excesiva de metales, reduciendo el estrés oxidativo, previniendo la ferroptosis, disminuyendo la inflamación y regulando los procesos de acortamiento de telómeros.
La empresa ha demostrado el potencial terapéutico de Telomir-1 en múltiples áreas, incluidos la reversión de la diabetes tipo 2 y el tratamiento de la enfermedad de Wilson. Tras estos resultados positivos, Telomir planea iniciar estudios in vitro utilizando líneas celulares humanas de progeria para validar aún más la efectividad del tratamiento.
텔로미르 제약 (NASDAQ:TELO)는 나기 바이오사이언스 SA와 함께 수행한 전임상 프로제리아 수명 연구에서 획기적인 발견을 발표했습니다. 이 연구는 wrn-1 유전자 변이를 가진 C. elegans 모델을 사용하여 텔로미르-1이 수명을 효과적으로 회복시키고 가속 노화 효과를 정상 개체와 비슷한 수준으로 정상화했음을 입증했습니다.
연구는 전 세계 400명 미만의 어린이에 영향을 미치는 드문 유전 질환인 프로제리아 치료에 초점을 맞췄으며, 이는 빠른 노화와 조기 사망을 초래합니다. 텔로미르-1은 과도한 금속 활성을 제어하고, 산화 스트레스를 줄이며, 페로pto시스를 예방하고, 염증을 낮추며, 텔로미어 단축 과정을 조절하는 새로운 소분자입니다.
회사는 텔로미르-1의 치료 잠재력을 제2형 당뇨병 역전 및 윌슨병 치료를 포함한 다양한 분야에서 입증했습니다. 이러한 긍정적인 결과에 따라, 텔로미르는 프로제리아 인간 세포주를 사용한 in vitro 연구를 시작하여 치료 효과의 유효성을 추가로 검증할 계획입니다.
Telomir Pharmaceuticals (NASDAQ:TELO) a annoncé des découvertes révolutionnaires d'une étude préclinique sur la durée de vie des patients atteints de progerie, réalisée avec Nagi Bioscience SA. L'étude, utilisant des modèles de C. elegans avec une mutation du gène wrn-1, a démontré que Telomir-1 a effectivement restauré la durée de vie et normalisé les effets du vieillissement accéléré à des niveaux comparables à ceux des spécimens normaux.
La recherche s'est concentrée sur le traitement de la progerie, une rare affection génétique touchant moins de 400 enfants dans le monde, provoquant un vieillissement rapide et une mort prématurée. Telomir-1, une nouvelle petite molécule, agit en contrôlant l'activité excessive des métaux, en réduisant le stress oxydatif, en prévenant la ferroptose, en abaissant l'inflammation et en régulant les processus de raccourcissement des télomères.
L'entreprise a démontré le potentiel thérapeutique de Telomir-1 dans plusieurs domaines, y compris l'inversion du diabète de type 2 et le traitement de la maladie de Wilson. Suite à ces résultats positifs, Telomir prévoit d'initier des études in vitro utilisant des lignées cellulaires humaines de progerie pour valider davantage l'efficacité du traitement.
Telomir Pharmaceuticals (NASDAQ:TELO) hat bahnbrechende Ergebnisse aus einer präklinischen Altersstudie zur Progerie in Zusammenarbeit mit Nagi Bioscience SA bekannt gegeben. Die Studie, die Modelle von C. elegans mit der wrn-1 Genmutation verwendet hat, zeigte, dass Telomir-1 die Lebensspanne effektiv wiederherstellte und die Auswirkungen der beschleunigten Alterung auf ein Niveau normalisierte, das mit normalen Exemplaren vergleichbar ist.
Die Forschung konzentrierte sich auf die Behandlung von Progerie, einer seltenen genetischen Erkrankung, die weniger als 400 Kinder weltweit betrifft und beschleunigtes Altern sowie vorzeitigen Tod verursacht. Telomir-1, ein neuartiges kleines Molekül, wirkt, indem es übermäßige Metallaktivität kontrolliert, oxidativen Stress reduziert, Ferroptose verhindert, Entzündungen senkt und die Prozesse des Telomerverkürzungs reguliert.
Das Unternehmen hat das therapeutische Potenzial von Telomir-1 in mehreren Bereichen demonstriert, darunter die Umkehrung von Typ-2-Diabetes und die Behandlung der Wilson-Krankheit. Nach diesen positiven Ergebnissen plant Telomir, in vitro Studien mit menschlichen Progerie-Zelllinien zu starten, um die Wirksamkeit der Behandlung weiter zu validieren.
- Successful preclinical study showing lifespan restoration in progeria models
- Demonstrated effectiveness in normalizing accelerated aging effects
- Multiple therapeutic applications identified including type 2 diabetes and Wilson's disease
- Advanced in vivo microfluidic technology validation
- Early-stage research to preclinical models
- Human trials not yet initiated
- Small target market for progeria (fewer than 400 patients worldwide)
Insights
The preclinical study results for Telomir-1 represent a significant scientific breakthrough in addressing accelerated aging conditions. The restoration of lifespan in wrn-1-mutated C. elegans to normal levels demonstrates robust proof-of-concept for Telomir-1's mechanism of action. The normalization of physiological parameters like movement velocity provides tangible evidence of improved healthspan, not just lifespan.
The compound's novel approach targeting metal ion regulation, particularly iron and copper homeostasis, addresses multiple cellular aging pathways simultaneously. This multi-modal mechanism differentiates it from traditional single-target therapies. The potential applications extend beyond progeria to more common age-related conditions, including Type 2 diabetes and Wilson's disease, significantly expanding the market opportunity.
However, it's important to note that while C. elegans studies are valuable initial proof-of-concept models, they represent a very early stage of development. The planned human cell line studies will be critical in validating these findings in a more relevant system. Success in those studies would significantly de-risk the program and potentially accelerate the path to clinical trials.
From an investment perspective, these preclinical results substantially enhance TELO's value proposition. With a market cap of just
The metal ion regulation mechanism is particularly intriguing as it could lead to multiple therapeutic applications, potentially creating a platform technology with multiple shots on goal. This diversification reduces development risk and increases potential return on investment. The company's strategic focus on both rare and common diseases allows for potential fast-track designations while maintaining exposure to larger market opportunities.
Key catalysts to watch include the upcoming human cell line studies and any regulatory interactions regarding clinical trial planning. These events could significantly impact valuation metrics and investor interest in the near term.
MIAMI, FL / ACCESSWIRE / January 7, 2025 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) ("Telomir"), an emerging leader in age-reversal science focused on treating the root causes of diseases rather than just their symptoms, announced today potentially groundbreaking findings from a preclinical progeria lifespan study conducted in collaboration with Nagi Bioscience SA. Utilizing C. elegans (nematode) models, in which the study demonstrated restoration of shortened lifespan and normalization of accelerated aging with Telomir-1.
The study was conducted in nematodes (C. elegans) with a mutation in the wrn-1 gene, which is equivalent to a gene in humans associated with Werner Syndrome (a form of Progeria). Compared to normal (wild-type) nematodes, those with wrn-1 depletion showed a significantly reduced mean and median lifespan. Utilizing advanced in vivo microfluidic technology, the study demonstrated lifespan restoration and normalization of accelerated agingeffects in wrn-1-mutated nematodes treated with Telomir-1. The treatment effectively restored longevity to levels not significantly different from normal animals. These effects included an extended healthy lifespan and the normalization of several physiological parameters, such as movement velocity and tail amplitude.
Laurent Mouchiroud, Ph.D., Co-founder and CSO of Nagi Bioscience SA, commented, "The analysis confirms that Telomir-1 not only restores lifespan but also effectively counters the decline observed in untreated populations. These findings underscore Telomir-1's potential to transform how we address age-related conditions by targeting their underlying cellular mechanisms."
Understanding Progeria: How Cellular Dysfunction Drives Accelerated Aging
Progeria, or Hutchinson-Gilford Progeria Syndrome, is a rare genetic condition that causes children to experience rapid aging. Fewer than 400 children worldwide are affected by this devastating disease, which leads to growth failure, joint stiffness, cardiovascular complications, and premature death, often in the early teens or twenties.
At the molecular level, progeria is driven by the accumulation of progerin, an abnormal protein that disrupts the cell nucleus and impairs normal gene expression. This damage accelerates telomere shortening, leaving DNA vulnerable and contributing to widespread cellular dysfunction. Telomeres, the protective caps at the ends of chromosomes, naturally shorten with normal aging, but this process is dramatically accelerated in progeria, leading to premature cellular aging.
Telomir-1: A Novel Therapeutic Approach
Telomir-1 is a groundbreaking small molecule designed to target key causes of cell damage and dysfunction. It works by controlling excess metal activity in the body, which helps reduce oxidative stress (damage caused by harmful molecules), prevent ferroptosis (a form of cell death linked to iron), lower inflammation, and regulate processes that can lead to telomere shortening, the progression of diseases, and faster aging.
Telomir-1's potential to regulate essential metal ions is central to its therapeutic approach:
Iron Overload: Excess iron contributes to oxidative stress, mitochondrial dysfunction, neurodegeneration, ferroptosis and accelerated cellular aging. It is linked to conditions such as insulin resistance, Alzheimer's disease, bone disorders, and Friedreich's ataxia.
Copper Imbalances: Abnormal copper levels impair organ function and disrupt metabolism, contributing to conditions such as neurodegenerative diseases and Wilson's disease.
By addressing these imbalances, Telomir-1 has the potential to protect against cellular damage and support healthy cellular function, further supporting its potential to mitigate age-related conditions.
"These results represent a significant milestone in our mission to develop therapies that address the root causes of diseases," said Dr. Itzchak Angel, Chief Scientific Advisor at Telomir. "Telomir-1's ability to significantly restore lifespan and normalize accelerated aging in progeria models demonstrates its promise as a transformative therapeutic option."
Advancing the Science of Aging
Telomir has demonstrated Telomir-1's broad therapeutic potential across multiple preclinical studies:
Reversing Aging and Improving Longevity: Telomir-1 has shown the ability to reverse the biological clock, improving both lifespan and health span in preclinical models.
Type 2 Diabetes: Telomir-1 appears to address insulin resistance at its root, achieving reversal to near pre-diabetic insulin resistance levels and glycemic control in preclinical studies.
Wilson's Disease: By regulating copper metabolism, Telomir-1 offers promise as a treatment for copper-related disorders, such as Wilson's disease.
"Our research continues to validate Telomir-1's ability to tackle aging at its core," said Erez Aminov, Chairman and CEO of Telomir. "By focusing on critical cellular processes, Telomir-1 offers a novel pathway to addressing conditions like progeria while also exploring its broader potential in other age-related diseases."
Next Steps in Progeria Research
Building on these findings, Telomir is preparing to launch in vitro studies using human progeria cell lines. These laboratory-based studies aim to further demonstrate Telomir-1's potential to restore cellular health and normalize aging processes.
About Telomir Pharmaceuticals, Inc.
Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) is a pre-clinical stage pharmaceutical company seeking to lead development in age-reversal science. The Company is focused on the development of Telomir-1, a novel small molecule designed to lengthen the DNA's protective telomere caps, which are crucial in the aging process. The Company's goal is to explore the potential of Telomir-1 starting with ongoing research in animals and then in humans.
Telomeres are the protective end caps of a chromosome made up of DNA sequences and proteins. As humans age, telomeres shorten, with metal reactivity accelerating the process, which presents humans and pet animals with an increased chance of contracting a number of degenerative and age-related diseases. Telomir's goal is to develop and gain regulatory approval for Telomir-1, proposed to be dosed orally, with the broader aim of promoting longevity and enhancing overall quality of life.
The Nobel Assembly at Karolinska Institute (Sweden) awarded the Nobel Prize in Physiology or Medicine in 2009 for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.
Telomir-1 is in preclinical development and has not yet been tested in humans. There is no assurance that Telomir-1 will proceed through development or will ultimately receive FDA approval for marketing.
Cautionary Note Regarding Forward-Looking Statements
This press release, statements of Telomir Pharmaceuticals' management or advisors related thereto, and the statements contained in the news story linked in this release contain "forward-looking statements," which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements may be identified by words such as "aims," "anticipates," "believes," "could," "estimates," "expects," "forecasts," "goal," "intends," "may," "plans," "possible," "potential," "seeks," "will," and variations of these words or similar expressions that are intended to identify forward-looking statements. Any such statements in this press release that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements include, without limitation, statements regarding (i) the anticipated benefits of the preclinical testing results described herein, (ii) anticipated timelines and subject matter for additional preclinical and clinical testing of Telomir-1 and (iii) the potential therapeutic benefits of Telomir-1 generally.
Any forward-looking statements in this press release are based on Telomir's current expectations, estimates and projections only as of the date of this release and are subject to a number of significant risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the potential use of the data from our studies, our ability to develop and commercialize Telomir-1 for specific indications and safety of Telomir-1. These and other risks concerning Telomir's programs and operations are described in additional detail in its Annual Report on Form 10-K for the fiscal year ended December 31, 2023, which is on file with the SEC. Telomir explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.
Telomir's lead compound, Telomir-1, is being investigated for its potential to address a range of conditions, including Type 2 diabetes, Wilson's disease, progeria, Alzheimer's disease, and cancer. The company's innovative approach aims to treat the root causes of disease, offering a promising path forward in improving patient care.
For more information, visit www.telomirpharma.com.
Contact Information
Helga Moya
info@telomirpharma.com
(786) 396-6723
SOURCE: Telomir Pharmaceuticals, Inc.
View the original press release on accesswire.com
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