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Tectonic Therapeutic to Host KOL Event on the Unmet Need in Group 2 PH-HFpEF and TX45 as a Potential Treatment on Thursday, December 12, 2024

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Tectonic Therapeutic (NASDAQ: TECX) announces a virtual key opinion leader (KOL) event scheduled for December 12, 2024, from 4:00 PM to 6:00 PM ET. The event will feature experts Dr. John R. Teerlink from UC San Francisco and Dr. Raymond L. Benza from Icahn School of Medicine at Mount Sinai.

The discussion will focus on the unmet medical needs and current treatment landscape for Group 2 Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction (Group 2 PH-HFpEF). The event will highlight Tectonic's lead program, TX45, an Fc-relaxin fusion protein that activates the RXFP1 receptor. TX45 is currently being evaluated in both Phase 1b hemodynamic and Phase 2 clinical proof-of-concept studies for Group 2 PH-HFpEF treatment.

Tectonic Therapeutic (NASDAQ: TECX) annuncia un evento virtuale con leader di pensiero (KOL) programmato per il 12 dicembre 2024, dalle 16:00 alle 18:00 ET. L'evento vedrà la partecipazione degli esperti Dr. John R. Teerlink dell'UC San Francisco e Dr. Raymond L. Benza della Icahn School of Medicine al Mount Sinai.

La discussione si concentrerà sui bisogni medici insoddisfatti e sul panorama attuale dei trattamenti per l'ipertensione polmonare di gruppo 2 a causa di insufficienza cardiaca con frazione di eiezione preservata (Group 2 PH-HFpEF). L'evento metterà in evidenza il programma principale di Tectonic, TX45, una proteina di fusione Fc-relaxin che attiva il recettore RXFP1. TX45 è attualmente in fase di valutazione sia in studi clinici emodinamici di fase 1b che in studi clinici di prova di concetto di fase 2 per il trattamento dell'ipertensione polmonare di gruppo 2 PH-HFpEF.

Tectonic Therapeutic (NASDAQ: TECX) anuncia un evento virtual con líderes de opinión clave (KOL) programado para el 12 de diciembre de 2024, de 4:00 PM a 6:00 PM ET. El evento contará con la participación de los expertos Dr. John R. Teerlink de UC San Francisco y Dr. Raymond L. Benza de la Icahn School of Medicine en Mount Sinai.

La discusión se centrará en las necesidades médicas no satisfechas y el panorama actual de tratamientos para la hipertensión pulmonar de grupo 2 debido a la insuficiencia cardíaca con fracción de eyección preservada (Group 2 PH-HFpEF). El evento destacará el programa principal de Tectonic, TX45, una proteína de fusión Fc-relaxina que activa el receptor RXFP1. TX45 se está evaluando actualmente en estudios clínicos hemodinámicos de fase 1b y pruebas de concepto clínicas de fase 2 para el tratamiento de la hipertensión pulmonar de grupo 2 PH-HFpEF.

텍토닉 테라퓨틱(Tectonic Therapeutic) (NASDAQ: TECX)은 2024년 12월 12일 오후 4시부터 6시(동부 표준시)까지 계획된 가상 주요 의견 리더(KOL) 이벤트를 발표했다. 이 이벤트에는 UC 샌프란시스코의 John R. Teerlink 박사와 Mount Sinai 아이칸 의과대학의 Raymond L. Benza 박사가 참여할 예정이다.

토론은 심박출 분수가 보존된 심부전으로 인한 2군 폐고혈압(Group 2 PH-HFpEF)의 충족되지 않은 의학적 요구와 현재 치료 환경에 초점을 맞출 것이다. 이번 이벤트에서는 텍토닉의 주요 프로그램인 TX45를 강조할 예정이다. TX45는 RXFP1 수용체를 활성화하는 Fc-relaxin 융합 단백질로 현재 2군 PH-HFpEF 치료를 위한 1b 단계의 혈역학적 연구와 2단계 임상 개념 증명 연구에서 평가되고 있다.

Tectonic Therapeutic (NASDAQ: TECX) annonce un événement virtuel avec des leaders d'opinion clés (KOL) prévu pour le 12 décembre 2024, de 16 h à 18 h (heure de l'Est). L'événement mettra en vedette les experts Dr. John R. Teerlink de l'UC San Francisco et Dr. Raymond L. Benza de l'École de Médecine Icahn du Mount Sinai.

La discussion portera sur les besoins médicaux non satisfaits et le paysage actuel des traitements pour l'hypertension pulmonaire de groupe 2 due à une insuffisance cardiaque avec fraction d'éjection préservée (Group 2 PH-HFpEF). L'événement mettra en lumière le programme phare de Tectonic, TX45, une protéine de fusion Fc-relaxine qui active le récepteur RXFP1. TX45 est actuellement évalué dans des études cliniques de Phase 1b hémodynamiques et des études de preuve de concept de Phase 2 pour le traitement de l'hypertension pulmonaire de groupe 2 PH-HFpEF.

Tectonic Therapeutic (NASDAQ: TECX) kündigt eine virtuelle Veranstaltung mit Meinungsführern (KOL) an, die für den 12. Dezember 2024 von 16:00 bis 18:00 Uhr ET geplant ist. Die Veranstaltung wird die Experten Dr. John R. Teerlink von der UC San Francisco und Dr. Raymond L. Benza von der Icahn School of Medicine am Mount Sinai vorstellen.

Die Diskussion wird sich auf die unerfüllten medizinischen Bedürfnisse und das aktuelle Behandlungsspektrum für Grupp 2 pulmonale Hypertonie aufgrund von Herzinsuffizienz mit erhaltener Auswurfgeschwindigkeit (Group 2 PH-HFpEF) konzentrieren. Die Veranstaltung wird das Hauptprogramm von Tectonic, TX45, ein Fc-relaxin-Fusionsprotein, das den RXFP1-Rezeptor aktiviert, hervorheben. TX45 wird derzeit in klinischen Studien der Phase 1b und Phase 2 als Konzeptnachweis zur Behandlung von Group 2 PH-HFpEF evaluiert.

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WATERTOWN, Mass., Dec. 03, 2024 (GLOBE NEWSWIRE) -- Tectonic Therapeutic, Inc. (NASDAQ: TECX) (“Tectonic”) a clinical stage biotechnology company focused on the discovery and development of therapeutic proteins and antibodies that modulate the activity of G-protein coupled receptors (“GPCRs”), today announced it will host a virtual key opinion leader (KOL) event on Thursday, December 12, 2024 from 4:00 PM to 6:00 PM ET. To register, click here.

Key opinion leaders will include John R. Teerlink, MD, FHFSA (University of California San Francisco) and Raymond L. Benza, MD, FACC, FAHA, FACP (Icahn School of Medicine at Mount Sinai), who will discuss the unmet medical need and current treatment landscape for patients with Group 2 Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction (Group 2 PH-HFpEF).

The event will focus on Tectonic’s lead program, TX45, an investigational Fc-relaxin fusion protein with optimized pharmacokinetics and biophysical properties that activates the RXFP1 receptor, the GPCR target of the hormone relaxin. TX45 is being evaluated in patients with Group 2 PH-HFpEF in an ongoing Phase 1b hemodynamic proof-of-concept study and a Phase 2 clinical proof-of-concept study.

A live question and answer session will follow the formal presentations.

About the Key Opinion Leaders:

Professor John R. Teerlink, MD, FACC, FAHA, FESC, FHFA, FHFSA, FRCP (London)
Professor Teerlink is Professor of Medicine at the University of California San Francisco (UCSF). After graduating from Swarthmore College with a Religion major, he received an MD from Harvard Medical School and completed his Internal Medicine residency and Cardiovascular Medicine fellowship at UCSF, as well as post-doctoral fellowships in Cardiovascular pharmacology (Hoffman-LaRoche; Basel, Switzerland), echocardiography (UCSF) and heart failure (UCSF-affiliated hospital).

He is actively involved in the design and execution of many heart failure clinical trials, serving on endpoint, data monitoring, steering and executive committees for numerous international studies investigating a variety of new pharmacologic therapies, as well as stem cell and gene therapies, diagnostic modalities and other devices. He was the lead clinical investigator for the serelaxin development program, serving as Principal Investigator for Pre-RELAX-AHF, RELAX-AHF, RELAX-AHF-2 and RELAX-Repeat, and as a steering committee member for RELAX-AHF-Asia.

Dr. Teerlink has served on the US FDA Cardiovascular and Renal Drug Advisory Committee, as well as on other FDA drug, device, diagnostics, and vaccine panels and serves as a consultant on pre-clinical and clinical development programs in multiple areas of cardiology, as well as in non-cardiovascular indications. Dr. Teerlink was a founding physician member of the American Association of Heart Failure Nurses and is a Past President of the Heart Failure Society of America. He was an Associate Editor for the Journal of Cardiac Failure, Guest Editor-in-Chief and Associate Editor for JACC: Heart Failure, and is a clinical scholar presenting many lectures and over 300 publications, including a chapter on Acute Heart Failure in Braunwald’s Heart Disease textbook. He was profiled in The Lancet as an internationally recognized leader in heart failure.

Raymond L. Benza, MD, FACC, FAHA, FACP
Dr. Benza is a Professor and System Director of Pulmonary Hypertension at the Icahn School of Medicine at Mount Sinai, Mount Sinai Fuster Heart Hospital. He is a fellow of the American College of Physicians, the American Heart Association Council on Clinical Cardiology, the American College of Chest Physicians and the American College of Cardiology. He is a diplomat of the American Board of Internal Medicine with certification in the subspecialties of cardiovascular diseases and advanced heart failure and transplantation. Dr. Benza currently holds administrative positions in the Pulmonary Vascular Research Institute and the International Society of Heart and Lung Transplantation and is the former treasurer of that society. He served on President Barak Obama’s Advisory Committee on Organ Transplantation (ACOT) in the Health Resources and Services Administration for 4 years and was knighted in 2015 by his Royal Highness Vittorio Emanuele of Italy for his philanthropic work in patients with pulmonary arterial hypertension and was admitted to the Association of University Cardiologists. He sits on multiple journal editorial committees and is the Steering Committee Chair for several industry trials in PAH. His primary clinical interests are the evaluation and treatment of advanced congestive heart failure, cardiac transplantation, and pulmonary arterial hypertension (PAH). He participates in major clinical studies of new therapies for the treatment of heart failure, mechanical support, and pulmonary hypertension. Dr. Benza is a funded investigator for the National Institutes of Health and the American Heart Association for his work in pulmonary arterial hypertension focusing on risk stratification, pharmacogenomics and new device therapies for this disease state.

About TX45, a long-acting Fc-relaxin fusion protein
TX45 is an investigational Fc-relaxin fusion protein with optimized pharmacokinetics and biophysical properties that activates the RXFP1 receptor, the G-protein coupled receptor target of the hormone relaxin. Relaxin is an endogenous protein, expressed at low levels in both men and women that is a pulmonary and systemic vasodilator with lusitropic, anti-fibrotic and anti-inflammatory activity. In normal human physiology, relaxin is upregulated during pregnancy where it exerts vasodilative effects, reduces systemic and pulmonary vascular resistance and increases cardiac output to accommodate the increased demand for oxygen and nutrients from the developing fetus. Relaxin also exerts anti-fibrotic effects on pelvic ligaments to facilitate delivery of the baby.

About Group 2 Pulmonary Hypertension in HFpEF
The World Health Organization has defined five groups of pulmonary hypertension (“PH”). Tectonic is focused on the Group 2 subtype, a condition that develops due to left-sided heart disease, specifically pulmonary hypertension secondary to left heart failure with preserved ejection fraction (“PH-HFpEF”). In patients with PH-HFpEF, chronic heart failure leads to increased blood pressure in the pulmonary arteries, exerting severe strain on the right side of the heart, which adapts poorly to the increased pressure. This increased pulmonary pressure gradually causes worsening exercise capacity, shortness of breath and right-sided heart failure which can lead to death. Although several Group 1 PH (Pulmonary Arterial Hypertension, PAH) medications have been explored in Group 2 PH, to date, no medications have been approved for its treatment.

About Tectonic
Tectonic is a biotechnology company focused on the discovery and development of therapeutic proteins and antibodies that modulate the activity of G-protein coupled receptors (“GPCRs”). Leveraging its proprietary technology platform called GEODe™ (GPCRs Engineered for Optimal Discovery), Tectonic is focused on developing biologic medicines that overcome the existing challenges of GPCR-targeted drug discovery and harness the human body to modify the course of disease. Tectonic focuses on areas of significant unmet medical need, often where therapeutic options are poor or nonexistent, as these are areas where new medicines have the potential to improve patient quality of life. Tectonic is headquartered in Watertown, Massachusetts. For more information, please visit www.tectonictx.com and follow on LinkedIn.

Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. All statements in this press release other than statements of historical facts are “forward-looking statements. These statements may be identified by words such as “aims,” “anticipates,” “believes,” “could,” “estimates,” “expects,” “forecasts,” “goal,” “intends,” “may,” “plans,” “possible,” “potential,” “seeks,” “will” and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include statements regarding: the design, objectives, initiation, timing, progress and results of clinical trials of Tectonic’s product candidates, including the ongoing Phase 1b and Phase 2 clinical trials for TX45 in Group 2 PH-HFpEF; and the potential properties and benefits of TX45. These forward-looking statements are based on Tectonic’s expectations and assumptions as of the date of this press release. Each of these forward-looking statements involves risks and uncertainties that could cause Tectonic’s clinical development programs, future results or performance to differ materially from those expressed or implied by the forward-looking statements. Many factors may cause differences between current expectations and actual results, including: the potential that success in preclinical testing and earlier clinical trials does not ensure that later clinical trials will generate the same results or otherwise provide adequate data to demonstrate the efficacy and safety of a product candidate; the impacts of macroeconomic conditions, including the conflict in Ukraine and the conflict in the Middle East, heightened inflation and uncertain credit and financial markets, on Tectonic’s business, clinical trials and financial position; unexpected safety or efficacy data observed during preclinical studies or clinical trials; clinical trial site activation or enrollment rates that are lower than expected; Tectonic’s ability to realize the benefits of its collaborations and license agreements; changes in expected or existing competition; changes in the regulatory environment; the uncertainties and timing of the regulatory approval process; and unexpected litigation or other disputes. Other factors that may cause Tectonic’s actual results to differ from those expressed or implied in the forward-looking statements in this press release are identified under the heading “Risk Factors” in Tectonic’s quarterly report on Form 10-Q filed with the SEC on November 12, 2024, and in other filings that Tectonic makes and will make with the SEC in the future. Tectonic expressly disclaims any obligation to update any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law. For more information, please visit www.tectonictx.com and follow on LinkedIn.

Source: Tectonic Therapeutic


FAQ

When is Tectonic Therapeutic (TECX) hosting its KOL event for TX45?

Tectonic Therapeutic is hosting the KOL event on Thursday, December 12, 2024, from 4:00 PM to 6:00 PM ET.

What is TX45 being developed to treat by Tectonic (TECX)?

TX45 is being developed to treat Group 2 Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction (Group 2 PH-HFpEF).

What clinical trial phases is Tectonic's (TECX) TX45 currently in?

TX45 is currently being evaluated in a Phase 1b hemodynamic proof-of-concept study and a Phase 2 clinical proof-of-concept study.

Who are the key opinion leaders speaking at Tectonic's (TECX) December 2024 event?

The KOL speakers are Dr. John R. Teerlink from UC San Francisco and Dr. Raymond L. Benza from Icahn School of Medicine at Mount Sinai.

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