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ScaleReady Announces multiple G-Rex® Grants have been awarded to leading investigators at the Baylor College of Medicine's Center for Cell and Gene Therapy

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ScaleReady has awarded G-Rex Grants totaling $475,000 to three leading investigators at Baylor College of Medicine's Center for Cell and Gene Therapy (CAGT).

Dr. Ann Leen received $275,000 for research on T cell therapies for AML and MDS. Dr. Katie McKenna received $100,000 to develop 3D tumor spheroid models. Dr. Dimitrios Laurin Wagner and Dr. Marie Pouzolles received $100,000 for non-viral gene editing platforms to create immune cell therapies.

The G-Rex Grant Program is a $20M initiative aimed at advancing cell and gene therapy development and manufacturing.

ScaleReady ha assegnato fondi G-Rex per un totale di $475,000 a tre importanti ricercatori del Center for Cell and Gene Therapy (CAGT) della Baylor College of Medicine.

La Dr.ssa Ann Leen ha ricevuto $275,000 per la ricerca sulle terapie con cellule T per l'AML e il MDS. La Dr.ssa Katie McKenna ha ricevuto $100,000 per sviluppare modelli di sfere tumorali 3D. Il Dr. Dimitrios Laurin Wagner e la Dr.ssa Marie Pouzolles hanno ricevuto $100,000 per le piattaforme di editing genico non virali per creare terapie con cellule immunitarie.

Il Programma G-Rex Grant è un'iniziativa da $20 milioni volta a promuovere lo sviluppo e la produzione di terapie cellulari e geniche.

ScaleReady ha otorgado subvenciones G-Rex por un total de $475,000 a tres investigadores destacados del Center for Cell and Gene Therapy (CAGT) de Baylor College of Medicine.

La Dra. Ann Leen recibió $275,000 para investigar terapias con células T para AML y MDS. La Dra. Katie McKenna recibió $100,000 para desarrollar modelos de esferoides tumorales en 3D. El Dr. Dimitrios Laurin Wagner y la Dra. Marie Pouzolles recibieron $100,000 para plataformas de edición genética no viral para crear terapias con células inmunitarias.

El Programa de Subvenciones G-Rex es una iniciativa de $20 millones destinada a avanzar en el desarrollo y fabricación de terapias celulares y genéticas.

ScaleReady는 Baylor College of Medicine의 세포 및 유전자 치료 센터(CAGT)에서 세 명의 주요 연구자에게 총 $475,000의 G-Rex 보조금을 수여했습니다.

Ann Leen 박사는 AML 및 MDS에 대한 T 세포 치료 연구를 위해 $275,000을 받았습니다. Katie McKenna 박사는 3D 종양 구체 모델을 개발하기 위해 $100,000을 받았습니다. Dimitrios Laurin Wagner 박사와 Marie Pouzolles 박사는 면역 세포 치료를 만들기 위한 비바이러스 유전자 편집 플랫폼에 대해 $100,000을 받았습니다.

G-Rex 보조금 프로그램은 세포 및 유전자 치료 개발 및 제조를 촉진하기 위한 2천만 달러 규모의 이니셔티브입니다.

ScaleReady a attribué des subventions G-Rex d'un montant total de 475 000 $ à trois chercheurs de renom du Centre de thérapie cellulaire et génique (CAGT) de la Baylor College of Medicine.

Le Dr Ann Leen a reçu 275 000 $ pour ses recherches sur les thérapies par cellules T pour les LMA et les LMC. Le Dr Katie McKenna a reçu 100 000 $ pour développer des modèles de sphéroïdes tumoraux en 3D. Le Dr Dimitrios Laurin Wagner et le Dr Marie Pouzolles ont reçu 100 000 $ pour des plateformes d'édition génique non virales pour créer des thérapies par cellules immunitaires.

Le programme de subventions G-Rex est une initiative de 20 millions de dollars visant à faire avancer le développement et la fabrication de thérapies cellulaires et géniques.

ScaleReady hat insgesamt $475,000 an G-Rex-Stipendien an drei führende Forscher am Center for Cell and Gene Therapy (CAGT) des Baylor College of Medicine vergeben.

Dr. Ann Leen erhielt $275,000 für die Forschung zu T-Zell-Therapien für AML und MDS. Dr. Katie McKenna erhielt $100,000 zur Entwicklung von 3D-Tumorsphäroid-Modellen. Dr. Dimitrios Laurin Wagner und Dr. Marie Pouzolles erhielten $100,000 für nicht-virale Genbearbeitungsplattformen zur Schaffung von Immunzelltherapien.

Das G-Rex-Stipendienprogramm ist eine 20-Millionen-Dollar-Initiative zur Förderung der Entwicklung und Herstellung von Zell- und Gentherapien.

Positive
  • ScaleReady awarded $475,000 in G-Rex Grants to leading researchers, potentially advancing T cell therapies and gene editing platforms.
  • Dr. Ann Leen's $275,000 grant focuses on T cell therapies for AML and MDS, possibly leading to new treatment methods.
  • Dr. Katie McKenna's $100,000 grant aims to develop 3D tumor spheroid models, which could improve tumor microenvironment studies.
  • Dr. Dimitrios Laurin Wagner and Dr. Marie Pouzolles received $100,000 to scale non-viral gene editing platforms, potentially creating transformative anti-cancer cell therapies.
Negative
  • None.

Insights

The $475,000 G-Rex Grant awards to Baylor College of Medicine researchers represent significant progress in cell therapy development. Dr. Leen's $275,000 grant for AML and MDS treatment research is particularly noteworthy given her extensive experience and patent portfolio. The focus on tumor-associated neoantigen specific T cell therapies could advance personalized medicine approaches.

The additional grants to Dr. McKenna and Dr. Wagner target important areas in CGT development: 3D tumor modeling and non-viral gene editing platforms. These innovations could potentially reduce development costs and improve therapy efficacy. The total $20M initiative by ScaleReady demonstrates substantial commitment to advancing CGT manufacturing capabilities.

ST. PAUL, Minn., Nov. 7, 2024 /PRNewswire/ -- ScaleReady, in collaboration with Wilson Wolf Manufacturing and Bio-Techne Corporation and CellReady, has awarded G-Rex Grants totaling $475,000 to three leading investigators at the Baylor College of Medicine's (BCM) Center for Cell and Gene Therapy Institute (CAGT).

Dr. Ann Leen, a Professor in the Department of Pediatrics at BCM's CAGT, received a $275,000 G-Rex Grant for process development and IND enabling studies related to tumor-associated neoantigen specific T cell therapies for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) in pre- and post-hematopoietic stem cell (HSC) transplant.  Dr. Leen has been with BCM's CAGT since 2002, is the senior or co-author on more than 100 publications, is a named inventor on 14 published patents (including several relating to G-Rex), served as the principal investigator on more than 15 clinical trials using "first in human" cell therapies, and is a co-founder of two T cell therapy companies (Allovir and Marker Therapeutics).

Dr. Katie McKenna, an Assistant Professor at BCM's CAGT, received a $100,000 G-Rex Grant to develop a novel G-Rex based approach for culturing three dimensional (3D) solid tumor spheroids. Dr. McKenna's vision is to establish these 3D tumor spheroid models as a reliable representation of the tumor microenvironment (TME) compared to in vivo murine studies that traditionally accompany an Investigational New Drug (IND) application.  Dr. McKenna will begin by establishing organoid models for pancreatic, breast, and lung cancer tissues before expanding to other tumor models.

Dr. Dimitrios Laurin Wagner, a Tenure-Track Assistant Professor at BCM's CAGT, and Dr. Marie Pouzolles, Staff Scientist in the Wagner Lab, received a $100,000 G-Rex Grant to develop innovative gene editing platforms to create potent immune cell therapies.  Specifically, the G-Rex Grant will be deployed to scale up the manufacture of non-viral gene edited T cells, leveraging their optimized non-viral CRISPR-Cas-based method for CAR insertion into specific loci of primary human T cells.  Dr. Wagner received his M.D., Ph.D. from Charité Universitätsmedizin Berlin where he was the head of Research and Development at the Berlin Center for Advanced Therapies and a junior group leader at the Berlin Institutes of Health Center for Regenerative Therapies.  At BCM's CAGT, Dr. Wagner and Dr. Pouzolles plan to move genome editing into the clinics to create transformative anti-cancer cell therapies.

"Baylor's Center for Cell and Gene Therapy has long been at the forefront of Cell and Gene Therapy innovation and played a pivotal role in the success of G-Rex technology.  G-Rex would not have become the gold standard for T cell therapy manufacturing without the input and help we received from the early adopters at Baylor.  It's gratifying to know that our G-Rex Grant program will help these accomplished investigators advance their scientific objectives" said John Wilson, CEO of Wilson Wolf Manufacturing and co-inventor of G-Rex.

ScaleReady's G-Rex Grant Program is a $20M initiative to advance the state of cell and gene-modified cell therapy (CGT) development and manufacturing by awarding individual Grant Awards worth up to $300,000.  G-Rex Grant Recipients also gain access to exclusive support from ScaleReady's growing consortium of G-Rex Grant Partners who bring best-in-class tools and technologies as well as unparalleled knowledge and expertise in the areas of cGMP manufacturing, quality and regulatory affairs, CGT business operations, and more.

For more information about the G-Rex® Grant Program, please contact info@scaleready.com.

About ScaleReady
ScaleReady provides the field of cell and gene-modified cell therapy (CGT) with a G-Rex centric manufacturing platform that enables the world's most practical, flexible, scalable, and affordable CGT drug product development and manufacturing.

The G-Rex manufacturing platform is currently used by a rapidly growing list of over 800 organizations and is producing drug products for approximately 50% of CGT clinical trials as well as 5 commercially approved CGT drugs.

CGT entities relying on the breadth and scope of ScaleReady's expertise can expect to save years of time and millions of dollars on the path to CGT commercialization.

For more information about the ScaleReady G-Rex® Grant Program, please contact info@scaleready.com.

About Wilson Wolf Manufacturing
Wilson Wolf (www.wilsonwolf.com) is dedicated to simplifying cell and gene-modified cell (CGT) therapy research, process development, and manufacturing.  This is being accomplished through its scalable G-Rex technology, which is used throughout the world in CGT applications ranging from basic research to commercial drug production.

Wilson Wolf's mission is to create hope for cancer patients, one G-Rex® device at a time.

About Bio-Techne Corporation
Bio-Techne Corporation (NASDAQ: TECH) is a global life sciences company providing innovative tools and bioactive reagents for the research and clinical diagnostic communities. Bio-Techne, in partnership with Wilson Wolf, is creating products such as media and cytokines that are specifically tailored to G-Rex® Bioreactors, including right-sized reagent quantities in containers that are tailored to high throughput closed-system manufacturing. For more information on Bio-Techne and its brands, please visit https://www.bio-techne.com or follow the Company on social media at: Facebook, LinkedIn, Twitter or YouTube.

Contact: David Clair, Vice President, Investor Relations & Corporate Development
david.clair@bio-techne.com
612-656-4416 

About CellReady LLC
CellReady is the world's first and only G-Rex centric contract development and manufacturing organization (CDMO) specializing in G-Rex based cell and gene-modified cell therapy development and manufacturing. The company offers a wide range of services to support the development and commercialization of these therapies.

CellReady's mission is to create hope for cancer patients, one G-Rex® process at a time.

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Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/scaleready-announces-multiple-g-rex-grants-have-been-awarded-to-leading-investigators-at-the-baylor-college-of-medicines-center-for-cell-and-gene-therapy-302297587.html

SOURCE Bio-Techne Corporation

FAQ

What is the total amount of G-Rex Grants awarded by ScaleReady?

ScaleReady awarded a total of $475,000 in G-Rex Grants.

Who received the largest G-Rex Grant and for what research?

Dr. Ann Leen received the largest G-Rex Grant of $275,000 for T cell therapies research for AML and MDS.

What is the focus of Dr. Katie McKenna's research funded by the G-Rex Grant?

Dr. Katie McKenna's research focuses on developing 3D tumor spheroid models.

What are Dr. Dimitrios Laurin Wagner and Dr. Marie Pouzolles using their G-Rex Grant for?

They are using the $100,000 G-Rex Grant to develop non-viral gene editing platforms for immune cell therapies.

What is the purpose of ScaleReady's G-Rex Grant Program?

The G-Rex Grant Program aims to advance cell and gene-modified cell therapy development and manufacturing.

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