Takeda Unveils New Research to Advance Patient Care in Hematology and Oncology at 63rd American Society of Hematology (ASH) Annual Meeting

Rhea-AI Summary

Takeda Pharmaceutical Company (TSE:4502/NYSE:TAK) announced it will present 23 company-sponsored abstracts at the 63rd American Society of Hematology (ASH) Annual Meeting from December 11-14, 2021 in Atlanta, Georgia. The presentations focus on advancing treatments in oncology and hematology, featuring pipeline candidates like Modakafusp Alfa (TAK-573) and Subasumstat (TAK-981). A key highlight includes updates on TAK-755, a novel therapy for Sickle Cell Disease and Congenital Thrombotic Thrombocytopenic Purpura.

Positive

• Presentation of 23 abstracts at ASH, indicating robust research activity.
• Focus on novel therapies in oncology using the innate immune system.
• Progress updates on TAK-755, a potential treatment for serious hematologic conditions.

Negative

• Pipeline candidates (TAK-573, TAK-981, TAK-755) are still in clinical development and not yet FDA approved, which poses uncertainty.

• Company to Present 14 Abstracts in Oncology and Nine in Hematology, Featuring New Insights to Advance Novel Medicines and Optimize Care within Existing Treatment Paradigms
• Oncology Abstracts Include Early Results from Immuno-Oncology Pipeline Candidates Modakafusp Alfa (TAK-573) and Subasumstat (TAK-981) that Leverage the Innate Immune System
• Hematology Abstracts Include Updates on TAK-755, the First and Only Investigational rADAMTS13 Replacement Therapy in Clinical Development, Which Is Being Explored in a Phase 1 Study in Sickle Cell Disease (SCD) and a Phase 3b Study in Congenital Thrombotic Thrombocytopenic Purpura (cTTP)

CAMBRIDGE, Mass. & OSAKA, Japan--(BUSINESS WIRE)-- Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) (“Takeda”) today announced that it will present a total of 23 company-sponsored abstracts at the 63^rd American Society of Hematology (ASH) Annual Meeting being held December 11-14, 2021 in Atlanta, Georgia. Takeda’s latest research in hematologic diseases focuses on optimizing patient care, while advancing novel approaches for patients with limited or ineffective treatment options.

Takeda Oncology will present data in multiple myeloma, lymphoma and leukemia from the company’s marketed products as well as provide early insights into the potential of therapies leveraging the innate immune system. In hematology, Takeda will present prospective, post-hoc and real-world data across a range of hematological disorders, aimed at addressing the breadth of needs within the bleeding disorders community, while investigating potentially transformative treatment options.

“At Takeda Oncology, improving patient care is the foundation for all we do,” said Christopher Arendt, Ph.D., Head of Oncology Cell Therapy and Therapeutic Area Unit of Takeda. “At this year’s ASH, we look forward to showcasing our deep legacy and leadership in the treatment of hematologic cancers by sharing data that will help to inform the optimal use of our established medicines and presenting research from two pipeline programs designed with the potential to drive potent and effective immune attacks against cancer. While early-stage, we continue to explore these new treatment pathways as we seek to outsmart cancer.”

“The hematological data we are highlighting at ASH this year demonstrates our commitment to furthering personalized care strategies, and leading scientific innovation to address unmet needs within the global bleeding disorders community,” added Neil Inhaber, Head of Global Medical Affairs, Rare Genetics and Hematology. “In addition to developing our promising pipeline of investigative molecules, which may have transformative potential for multiple rare and life-threatening hematological conditions, we remain focused on expanding the use of our current portfolio to benefit more people living with rare bleeding disorders.”

A full list of company-sponsored abstracts can be found here.

rADAMTS13 (TAK-755), modakafusp alfa (TAK-573), and subasumstat (TAK-981) are investigational compounds that have not been approved for use by the U.S. Food and Drug Administration (FDA), European Medicines Agency (EMA), or any other regulatory authorities.

Takeda’s Commitment to Oncology

Our core R&D mission is to deliver novel medicines to patients with cancer worldwide through our commitment to science, breakthrough innovation and passion for improving the lives of patients. Whether it’s with our hematology therapies, our robust pipeline, or solid tumor medicines, we aim to stay both innovative and competitive to bring patients the treatments they need. For more information, visit www.takedaoncology.com.

Takeda’s Commitment to Hematology

Takeda is a leader in hemophilia with the longest heritage and market-leading portfolio, backed by established safety and efficacy profiles with decades of real-world experience. We have 70+ years driving innovation for patients and a broad portfolio of 11 products across multiple bleeding disorders. Our experience as a leader in hematology means we are well prepared to meet today’s needs as we pursue future developments in the care of blood disorders. Together with the hematology community, we are raising expectations for the future, including earlier diagnosis, earlier and full protection against bleeds, and more personalized patient care.

About Takeda Pharmaceutical Company Limited

Takeda Pharmaceutical Company Limited (TSE: 4502/NYSE: TAK) is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions. For more information, visit https://www.takeda.com.

Important Notice

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The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

Forward-Looking Statements

This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could” “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: https://www.takeda.com/investors/sec-filings/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.

Medical information

This press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.

View source version on businesswire.com: https://www.businesswire.com/news/home/20211207005371/en/

Japanese Media

Ryoko Matsumoto

ryoko.matsumoto@takeda.com

+81 (0) 3-3278-3414

Oncology U.S. and International Media

Sara Noonan

sara.noonan@takeda.com

+1-617-551-3683

Hematology U.S. and International Media

David Murdoch

david.murdoch@takeda.com

+1 774-276-7448

Source: Takeda Pharmaceutical Company Limited

FAQ

What will Takeda present at the ASH Annual Meeting 2021?

Takeda will present 23 abstracts focusing on oncology and hematology, including new insights on novel therapies and their ongoing clinical trials.

What are the key drugs highlighted in Takeda's ASH presentation?

The key drugs include Modakafusp Alfa (TAK-573), Subasumstat (TAK-981), and TAK-755.

When is the ASH Annual Meeting where Takeda will present?

The ASH Annual Meeting is scheduled from December 11-14, 2021.

What is the significance of TAK-755 in Takeda's research?

TAK-755 is the first investigational rADAMTS13 replacement therapy in development for Sickle Cell Disease and Congenital Thrombotic Thrombocytopenic Purpura.

What is the stock symbol for Takeda Pharmaceutical Company?

The stock symbol for Takeda is TAK, listed on both the Tokyo Stock Exchange and NYSE.