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Takeda Pharmaceutical Company Limited (NYSE: TAK), a Japanese multinational corporation, stands as Asia's largest and one of the globe's top 20 pharmaceutical giants by revenue. Headquartered in Tokyo, Takeda operates across approximately 80 countries, merging American and British roots into its vast global presence.
With a revenue of JPY 4.3 trillion in fiscal 2023, Takeda dedicates its efforts predominantly to five therapeutic areas: oncology, gastroenterology, neuroscience, rare diseases, and plasma-derived therapies, which collectively generate more than 80% of its revenue. Takeda’s global footprint is diversified, with 50% of its revenue originating from the US, 20% from Japan, and another 20% from Europe and Canada.
Noteworthy for its robust pipeline and commitment to innovation, Takeda partners with various organizations to push the boundaries of medical research. A recent highlight includes a joint venture with Astellas Pharma Inc. and Sumitomo Mitsui Banking Corporation. This collaboration aims to incubate early drug discovery programs, striving to transition academic breakthroughs into practical medical treatments.
Moreover, Takeda's strategic partnership with Neurocrine Biosciences to develop NBI-1065845, an investigational treatment for major depressive disorder, showcases its dedication to addressing unmet medical needs. The positive Phase 2 results of the SAVITRI™ study underline the potential of NBI-1065845 to provide hope for patients with inadequate responses to existing treatments.
Takeda's philosophy focuses on creating a healthier world through life-transforming treatments in its core areas. Their values-based, R&D-driven approach has sustained their leadership in the pharmaceutical sector for over two centuries.
Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) has submitted a New Drug Application (NDA) for lanadelumab, a monoclonal antibody therapy, to the MHLW in Japan. This treatment targets hereditary angioedema (HAE), a rare genetic disorder affecting 2,000-3,000 people in Japan, of whom only 450 are diagnosed. Lanadelumab proved effective in reducing monthly HAE attacks by up to 87% in clinical trials. If approved, it will be available as a pre-filled syringe, enhancing treatment access for patients with unmet medical needs.
Takeda Pharmaceutical Company Limited (TAK) aims for over JPY 1 trillion (approx. US$9 billion) in revenue from its Growth and Emerging Markets Business Unit by FY2030, signaling more than double its current revenues. This growth strategy focuses on key markets like Brazil, China, and India, with over 20% expected annual growth in China. Takeda plans to enhance access to innovative therapies, including a dengue vaccine candidate (TAK-003), to address unmet patient needs. The company emphasizes a patient-centric approach while maintaining a commitment to local health systems.
BioLife Plasma Services, a division of Takeda, announced the opening of a new plasma donation center in Deptford, New Jersey, to address the rising demand for plasma donations, particularly due to the pandemic. This center will generate approximately $2-3 million annually through donor compensation and create 60 jobs in the community. The facility is part of a network of over 140 centers, known for their high safety standards, and aims to provide essential therapies for patients with rare conditions. The center opens on March 13, and strict health measures are in place to ensure donor safety.
Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) has announced its decision to acquire Maverick Therapeutics, Inc., specializing in bispecific T-cell targeted immunotherapies. This acquisition includes Maverick's COBRA™ platform and key candidates like TAK-186 and TAK-280, aimed at treating specific solid tumors. The transaction, valued up to $525 million, hinges on antitrust reviews and is anticipated to finalize in Q1 of Takeda's fiscal year 2021. This strategic move enhances Takeda's oncology portfolio and development capabilities, strengthening its commitment to innovative cancer treatments.
Takeda Pharmaceutical Company and Ovid Therapeutics announced an exclusive agreement for Takeda to gain global rights to develop and commercialize soticlestat for treating developmental and epileptic encephalopathies, including Dravet syndrome and Lennox-Gastaut syndrome. Takeda will pay Ovid $196 million upfront and could pay up to $660 million in milestones. This agreement relieves Ovid from further financial obligations related to the original collaboration. Phase 3 studies are set to begin in Q2 2021, building on positive Phase 2 ELEKTRA study results.
Children's National Hospital and Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) have launched the Rare Disease Clinical Activity Protocols (Rare-CAP) program. This initiative aims to standardize diagnosis and care for patients with rare diseases, supported by a $3.85 million investment from Takeda over five years. Rare-CAP will utilize a protocol platform that engages patients and families, providing real-time updates. The partnership emphasizes Takeda's commitment to innovation in rare diseases, as these conditions often lack standardized care protocols.
Takeda Pharmaceutical has agreed to transfer marketing rights and assets of four non-core type 2 diabetes products to Teijin Pharma for JPY 133 billion. This divestment, which generated JPY 30.8 billion in sales in FY2019, aligns with Takeda's strategy to focus on core areas such as Gastroenterology and Oncology. Proceeds from the sale will be used to reduce debt, aiming for a net debt/adjusted EBITDA ratio of 2x by FY2023. The transaction is scheduled for completion on April 1, 2021, and is expected to enhance net profit by approximately JPY 90 billion.
BioLife Plasma Services, part of Takeda, has opened a new plasma donation center in Moreno Valley, CA, responding to the increased need for plasma donations during the pandemic. This center is the first in California, with plans for more in Rialto, Corona, and Riverside. The expansion aims to boost local economies, contributing $2-3 million annually and generating up to 70 jobs per center. Takeda emphasizes the urgent demand for plasma-based therapies, especially for patients with rare conditions, and is implementing enhanced safety measures in light of COVID-19.
Takeda Pharmaceutical Company (TSE:4502/NYSE:TAK) announced the dosing of the first participant in its Phase 1/2 study of Novavax's COVID-19 vaccine candidate (TAK-019) in Japan. This follows the completion of enrollment in a similar study for Moderna's TAK-919 vaccine. Takeda aims to manufacture over 250 million doses of TAK-019 and import 50 million doses of TAK-919 for distribution in Japan. Results from both studies are anticipated in 2021, with an intention to distribute the vaccines pending regulatory approvals.
Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) announced positive results from the Phase 3 SOLSTICE trial for TAK-620 (maribavir), aimed at treating refractory cytomegalovirus (CMV) infections in transplant recipients. The trial met its primary endpoint, showing 55.7% of patients cleared CMV viremia by Study Week 8 compared to 23.9% with conventional therapies (p<0.001). Maribavir also demonstrated lower rates of treatment-related toxicities, such as neutropenia and acute kidney injury. The trial's promising findings may redefine CMV treatment in transplant patients, although regulatory approvals remain uncertain.
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