Syros to Present New Preclinical Data on its CDK12 Inhibitor Program at the American Association for Cancer Research (AACR) Annual Meeting 2022

Rhea-AI Summary

Syros Pharmaceuticals (NASDAQ:SYRS) announced the presentation of new preclinical data on its CDK12 inhibitor program at the AACR Annual Meeting 2022, scheduled from April 8-13 in New Orleans, Louisiana. The e-poster will reveal that the selective CDK12 inhibitor exhibits strong anti-tumor activity both in vitro and in vivo across various cancer models and shows improved effects when combined with DNA-damaging agents. Syros aims to nominate a development candidate from this program in the latter half of 2022.

Positive

• Strong anti-tumor activity of the CDK12 inhibitor presented at AACR.
• Plans to nominate a development candidate in the second half of 2022.

Negative

• None.

CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Syros Pharmaceuticals (NASDAQ:SYRS), a leader in the development of medicines that control the expression of genes, today announced that it will present new preclinical data on its CDK12 inhibitor program at the American Association for Cancer Research (AACR) Annual Meeting 2022, taking place April 8-13 in New Orleans, Louisiana.

The online-only e-poster will include data that show Syros’ orally available, selective CDK12 inhibitor has potent single agent activity in vitro and in vivo in multiple cancer models as well as enhanced antitumor effect in combination with DNA damaging agents. These data support Syros’ plans to nominate a development candidate from its CDK12 inhibitor program in the second half of 2022.

Details of the e-poster presentation are as follows:

Presentation Title: An oral and selective CDK12 inhibitor demonstrates robust anti-tumor activity
Session Title: Molecular Targets
Session Category: Experimental and Molecular Therapeutics
Abstract Number: 5393

The abstract is now available on the AACR conference website: https://www.aacr.org/meeting/aacr-annual-meeting-2022/. The e-poster will become available on the AACR conference website at 1:00 p.m. ET on Friday, April 8^th.

About Syros Pharmaceuticals

Syros is redefining the power of small molecules to control the expression of genes. Based on its unique ability to elucidate regulatory regions of the genome, Syros aims to develop medicines that provide a profound benefit for patients with diseases that have eluded other genomics-based approaches. Syros is advancing a robust clinical-stage pipeline, including: tamibarotene, a first-in-class oral selective RARα agonist in RARA-positive patients with higher-risk myelodysplastic syndrome and acute myeloid leukemia; SY-2101, a novel oral form of arsenic trioxide in patients with acute promyelocytic leukemia; and SY-5609, a highly selective and potent oral CDK7 inhibitor in patients with select solid tumors and blood cancers. Syros also has multiple preclinical and discovery programs in oncology and monogenic diseases. For more information, visit www.syros.com and follow us on Twitter (@SyrosPharma) and LinkedIn.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, including without limitation statements regarding Syros’ clinical development plans, including with respect to the timing of nomination of Syros’ next development candidate. The words ‘‘anticipate,’’ ‘‘believe,’’ ‘‘continue,’’ ‘‘could,’’ ‘‘estimate,’’ ‘‘expect,’’ “hope,” ‘‘intend,’’ ‘‘may,’’ ‘‘plan,’’ ‘‘potential,’’ ‘‘predict,’’ ‘‘project,’’ ‘‘target,’’ ‘‘should,’’ ‘‘would,’’ and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including Syros’ ability to: advance the development of its programs, including CDK12, under the timelines it projects in current and future clinical trials; demonstrate in any current and future clinical trials the requisite safety, efficacy and combinability of its drug candidates; sustain the response rates and durability of response seen to date with its drug candidates; successfully develop a companion diagnostic test to identify patients with the RARA biomarker; obtain and maintain patent protection for its drug candidates and the freedom to operate under third party intellectual property; obtain and maintain necessary regulatory approvals; identify, enter into and maintain collaboration agreements with third parties; manage competition; manage expenses; raise the substantial additional capital needed to achieve its business objectives; attract and retain qualified personnel; and successfully execute on its business strategies; risks described under the caption “Risk Factors” in Syros’ Annual Report on Form 10-K for the year ended December 31, 2020 and Quarterly Report on Form 10-Q for the quarter ended September 30, 2021, each of which is on file with the Securities and Exchange Commission; and risks described in other filings that Syros makes with the Securities and Exchange Commission in the future. In addition, the extent to which the COVID-19 pandemic continues to impact Syros’ workforce and its clinical trial operations activities, and the operations of the third parties on which Syros relies, will depend on future developments, which are highly uncertain and cannot be predicted with confidence, including the duration and severity of the pandemic, additional or modified government actions, and the actions that may be required to contain the virus or treat its impact. Any forward-looking statements contained in this press release speak only as of the date hereof, and Syros expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220308005018/en/

Media Contact:

Courtney Solberg

Syros Pharmaceuticals

917-698-9253

csolberg@syros.com

Investor Contact:

Hannah Deresiewicz

Stern Investor Relations, Inc.

212-362-1200

hannah.deresiewicz@sternir.com

Source: Syros Pharmaceuticals

FAQ

What are the key findings from Syros Pharmaceuticals' CDK12 inhibitor presentation?

The CDK12 inhibitor shows significant anti-tumor activity both in vitro and in vivo and enhances the effects when combined with DNA-damaging agents.

When will Syros announce its next development candidate?

Syros plans to nominate its next development candidate from the CDK12 program in the second half of 2022.

What event will Syros Pharmaceuticals present its CDK12 inhibitor data?

Syros will present the data at the AACR Annual Meeting 2022 from April 8-13 in New Orleans.

Where can I find the e-poster presentation details for Syros Pharmaceuticals?

Presentation details can be found on the AACR conference website, with the e-poster available from April 8 at 1:00 p.m. ET.