Welcome to our dedicated page for Shattuck Labs news (Ticker: STTK), a resource for investors and traders seeking the latest updates and insights on Shattuck Labs stock.
Introduction
Shattuck Labs, Inc. is a clinical-stage biotechnology company that is pioneering the development of dual-action fusion proteins, a new class of biologic medicines. Utilizing their proprietary Agonist Redirected Checkpoint (ARC®) platform, the company is dedicated to designing bi-functional fusion proteins capable of simultaneously inhibiting immune checkpoints and activating costimulatory pathways. This approach is instrumental in reactivating anti-tumor immune responses and modulating autoimmune mechanisms, addressing significant unmet needs in oncology and autoimmune disorders.
Innovative Technology and Platform
The core of Shattuck Labs’ innovation lies in its proprietary ARC® platform, which enables the rational design of fusion proteins with a dual mechanism of action. By targeting key immune checkpoints such as CD47 and PD-1 while concurrently stimulating costimulatory receptors like CD40 and OX40, the company is able to enhance the efficacy of immune-mediated treatments without the need for multiple separate therapies. This strategic integration of inhibitory and agonistic functions within a single molecule sets the company apart in the competitive biotechnology landscape.
Product Pipeline and Clinical Programs
Shattuck Labs is actively advancing several clinical programs with its innovative fusion protein candidates:
- SL-172154 (SIRPα-Fc-CD40L): Designed to block inhibitory checkpoints and stimulate immune activation, this candidate is undergoing early-phase clinical evaluation to address advanced cancer indications.
- SL-279252 (PD1-Fc-OX40L): Developed in collaboration with a major pharmaceutical partner, this compound exemplifies the company’s commitment to designing fusion proteins that combine checkpoint inhibition with costimulatory activation.
- Gamma Delta T Cell Engager Platform: Known as gadlen™, this innovative approach aims to bridge gamma delta T cells to tumor antigens, thereby enhancing the immune system’s ability to target and destroy cancer cells.
Throughout these programs, Shattuck Labs maintains a balanced focus on therapeutic innovation, clinical safety, and efficacy, which is thoroughly reflected in their robust preclinical data and ongoing Phase 1 clinical studies.
Market Position and Competitive Landscape
In the dynamic field of biotechnology, Shattuck Labs has carved out a unique niche by leveraging advanced protein engineering and novel therapeutic strategies. The company’s dual-action approach not only positions it as an innovator in the development of biologic medicines but also enables it to address complex diseases with limited treatment options. With clinical programs targeting both hematologic malignancies and autoimmune conditions, Shattuck Labs stands as a significant contributor in the realm of precision immunotherapy and therapeutic innovation.
Expertise, Experience, and Corporate Profile
With offices located in Austin, Texas and Durham, North Carolina, Shattuck Labs benefits from a strong foundation in regional biotech hubs known for their robust research and development ecosystems. The company’s leadership and scientific teams bring extensive expertise in protein engineering, immuno-oncology, and drug development. Their work not only reflects a deep understanding of molecular biology and immune regulation but also underscores a disciplined approach to clinical development that is critical for advancing novel therapeutics safely and effectively.
Understanding the Bi-Functional Fusion Protein Approach
At the heart of Shattuck Labs’ operations is the concept of a bi-functional fusion protein – a therapeutic designed to perform two critical functions within one molecule. This innovative approach allows for:
- Simultaneous inactivation of inhibitory checkpoints that normally prevent an effective immune response.
- Activation of costimulatory pathways that enhance the body's ability to combat cancer cells or manage autoimmune responses.
This dual mechanism is a testament to the company’s expertise in synthesizing complex biological data and leveraging cutting-edge protein design to create more potent therapies with a potentially improved safety profile.
Conclusion
Shattuck Labs, Inc. represents a forward-thinking force in the biotechnology industry. By integrating innovative dual-action fusion proteins with state-of-the-art research and a well-structured clinical development program, the company continues to bolster its position as an informed and experienced player in the field of biologic medicine. Investors and industry stakeholders will find that the company not only addresses pressing medical challenges but also exemplifies a commitment to scientific rigor and therapeutic innovation.
Shattuck Labs (NASDAQ: STTK) announced the appointment of Abhinav A. Shukla, Ph.D., as Chief Technical Officer. His extensive experience in biologics manufacturing and gene therapy is expected to enhance the company's capabilities in developing its ARC and GADLEN platform compounds. Dr. Shukla previously held senior positions at Redpin Therapeutics and CRISPR Therapeutics, contributing to numerous investigational new drug applications and commercialized therapeutics. Shattuck aims to advance its bi-functional fusion proteins targeting cancer and autoimmune diseases through its innovative platforms.
Shattuck Labs (NASDAQ: STTK) reported Q1 2021 financial results, showing a net loss of $11.8 million, or $0.28 per share, compared to a $6.6 million loss in Q1 2020. Cash and equivalents totaled $321.2 million as of March 31. The company is on track for initial dose-escalation data from its clinical trials of CD47 inhibitor SL-172154 and PD-1 inhibitor SL-279252 in the second half of 2021. R&D expenses rose to $10.3 million, reflecting ongoing clinical developments. Financial guidance indicates sufficient funds to support operations through 2024.
Shattuck Labs (NASDAQ: STTK), a biotechnology firm, announced participation in two upcoming conferences. CEO Taylor Schreiber will discuss multifunctional soluble biologics at the 32nd Annual Cello Health Cancer Progress Conference on May 5, 2021, and ranking product attributes at the 17th Annual PEGS Boston Conference on May 11, 2021. The company focuses on developing bi-functional fusion proteins targeting cancer and autoimmune diseases, led by the SL-172154 program in Phase 1 trials, designed to block immune checkpoints.
Shattuck Labs, Inc. (NASDAQ: STTK) will participate in the 7th Annual Truist Securities Life Sciences Summit on May 5, 2021. CEO Taylor Schreiber and CFO Andrew Neill will engage in a fireside chat at 1:50 p.m. EST. The event will be accessible via a live webcast, with a replay available for 90 days after the presentation. Shattuck specializes in developing bi-functional fusion proteins aimed at treating cancer and autoimmune diseases, leveraging their proprietary ARC® platform.
Shattuck Labs (NASDAQ: STTK) presented two posters at the AACR Annual Meeting on promising therapeutic developments. The first poster showcased SL-9258, a TIGIT-Fc-LIGHT fusion protein, demonstrating effectiveness against PD1 resistance in tumor models. The second presentation detailed GADLEN™, a platform targeting gamma delta T cells to treat hematologic malignancies. CEO Taylor Schreiber emphasized the innovation and potential to address unmet medical needs in cancer treatment. These advancements highlight Shattuck's commitment to pioneering new biologic medicines for cancer and autoimmune diseases.
Shattuck Labs, Inc. (NASDAQ: STTK) will participate in the 20th Annual Needham Healthcare Conference held virtually from April 12-15, 2021. CEO Taylor Schreiber, M.D., Ph.D., and CFO Andrew Neill will present on April 14, 2021, at 11:00 a.m. EST in a fireside chat format. The event can be accessed through a live webcast, with a replay available for up to 90 days. Shattuck Labs focuses on developing bi-functional fusion proteins aimed at treating cancer and autoimmune diseases, with its lead candidate SL-172154 currently in a Phase 1 trial.
Shattuck Labs (NASDAQ: STTK) announced the promotion of Andrew R. Neill to Chief Financial Officer, previously Vice President of Finance and Corporate Strategy. Neill is credited for his role in raising $330.5 million through recent financing efforts, which include Series B and B-1 financings and an IPO. CEO Taylor Schreiber emphasized Neill’s past contributions and strategic impact on advancing Shattuck's clinical-stage ARC compounds and GADLEN platform. Neill expressed enthusiasm for driving the company's growth in his new role, focusing on improving cancer treatment options.
Shattuck Labs (NASDAQ: STTK) reported its Q4 and full-year 2020 financial results, revealing a cash position of $335.4 million as of December 31, compared to $39.1 million in 2019. R&D expenses rose to $9.8 million for Q4 2020, while G&A expenses increased to $3.6 million. The net loss for Q4 was $12.0 million, or $0.31 per share, versus $7.4 million, or $0.97 per share in the prior year. Shattuck anticipates Phase 1 trial data for its lead CD47 checkpoint inhibitor SL-172154 and PD-1 inhibitor SL-279252 in H2 2021, while projecting sufficient cash to fund operations through 2024.
Shattuck Labs, a clinical-stage biotechnology company, announced that two posters will be presented at the AACR Annual Meeting from April 10-15, 2021. The first poster focuses on preclinical data from its GADLEN™ platform, while the second discusses an in vivo model of checkpoint acquired resistance and the therapeutic potential of SL-9258 (TIGIT-Fc-LIGHT). Presenters include Dr. Suresh de Silva and Dr. George Fromm. The abstracts are numbered 1736 and 1697, respectively. Additional details will be available on the AACR website and Shattuck's Events & Presentations section post-event.
Shattuck Labs, Inc. (NASDAQ: STTK) announced its participation in two upcoming investor conferences. CEO Taylor Schreiber will speak at the Cowen 41st Annual Health Care Conference on March 2, 2021, and VP Andrew Neill will present at the Oppenheimer 31st Annual Healthcare Conference on March 16, 2021. Shattuck is focused on developing bi-functional fusion proteins for cancer and autoimmune disease treatment, with its lead program SL-172154 currently in a Phase 1 trial. The company also collaborates with Takeda Pharmaceuticals on another candidate, SL-279252.
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