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Surrozen, Inc. (Nasdaq: SRZN) is a clinical-stage biotechnology firm based in South San Francisco, focused on pioneering regenerative medicine. The company leverages its proprietary technologies to selectively activate the Wnt signaling pathway, a crucial mediator of tissue repair and regeneration. Founded by esteemed scientists from Stanford University, Surrozen aims to unlock the body's self-renewal capabilities through innovative therapeutic approaches.
The company's product pipeline includes several promising candidates:
- SZN-043: Surrozen's lead candidate, SZN-043, uses the company's SWEETS™ technology to treat severe liver diseases, specifically alcohol-associated hepatitis. Following a successful Phase 1a trial that demonstrated safety and target engagement, the company has initiated a Phase 1b clinical trial, with proof-of-concept data anticipated by mid-2025.
- SZN-413: Developed for retinal vascular-associated diseases, SZN-413 leverages Surrozen's SWAP™ technology. Preclinical models have shown that SZN-413 can stimulate Wnt signaling in the eye, potentially inducing normal retinal vessel regrowth. The company has partnered with Boehringer Ingelheim for further research and development, with milestone payments potentially reaching $587.0 million.
Surrozen's strategic direction also includes a strong focus on severe eye diseases and potential applications in other tissues such as the lung and kidney. The company recently published data indicating the potential of Wnt mimetic technologies to treat idiopathic pulmonary fibrosis.
With $43.4 million in cash, cash equivalents, and marketable securities as of September 2023, Surrozen is well-positioned financially to continue its innovative research and clinical trials. The company emphasizes transparency and forward-looking statements, promising continued updates as they advance their clinical programs.
For more details about career opportunities and their latest news, please visit Surrozen's official website.
Surrozen, Inc. (Nasdaq: SRZN), a biotech firm focusing on Wnt pathway therapeutics, appointed Eric Bjerkholt to its Board of Directors. Bjerkholt, who has extensive experience in biotechnology, is currently the CFO of Chinook Therapeutics and previously served as CFO of Aimmune Therapeutics, leading its $2.6 billion acquisition by Nestlé Health Science. Surrozen's Board now consists of nine members with diverse expertise in the field. CEO Craig Parker expressed confidence in Bjerkholt's insights and strategic acumen, especially as the company aims to develop technologies addressing significant medical needs.
Surrozen, Inc. (SRZN) announced key developments in its clinical pipeline, enrolling the first patient in the Phase 1a trial of SZN-043 for chronic liver disease, with data expected by the end of 2023. The company plans to initiate a Phase 1b trial for severe alcoholic hepatitis in 2024, anticipating proof-of-concept data in the latter half of 2024. SZN-1326's Phase 1a trial in healthy volunteers is set to resume by mid-2023, with potential ulcerative colitis data expected in 2024. Surrozen's restructuring initiatives have extended its cash runway into late 2024. The company's financial position includes approximately $75.8 million in cash, with R&D expenses reduced by 15% in 2023.
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