SciSparc’s Collaboration with Clearmind Medicine Continues to Bear Fruit With New Scientific Article Showing MEAI Potential as a Novel Weight Loss Drug

Rhea-AI Summary

SciSparc (Nasdaq: SPRC) has announced promising results from a study on 5-methoxy-2-aminoindane (MEAI), conducted in collaboration with Clearmind Medicine Inc. (Nasdaq: CMND). The study, published in ACS Pharmacology and Translational Science, demonstrates MEAI's potential as a novel weight loss drug. Key findings include:

• Significant weight loss in diet-induced obese mice
• Improved glucose metabolism and increased energy expenditure
• Decreased fatty liver and reduced fat accumulation
• Well-tolerated combination treatment with elevated metabolic processes

This research is part of SciSparc and Clearmind's ongoing collaboration since 2022, focusing on developing innovative treatments for addictions, obesity, and metabolic syndrome by combining SciSparc's Palmitoylethanolamide (PEA) with Clearmind's MEAI.

Positive

• Promising results from MEAI study showing potential as a weight loss drug
• Significant reduction in weight loss and fat mass in diet-induced obese mice
• Improvement in glucose metabolism and increased energy expenditure
• Decrease in fatty liver and reduced fat accumulation
• Well-tolerated combination treatment with elevated metabolic processes
• Multiple patent applications filed for safer and more effective therapeutic options

Negative

• None.

Insights

Medical Research Analyst

This study on MEAI's potential as a weight loss drug presents promising preclinical results. The findings show significant weight reduction, improved glucose metabolism and decreased fatty liver in diet-induced obese mice. Notably, MEAI achieved these effects while preserving lean mass and without reducing food intake, suggesting a unique mechanism of action.

The increased energy expenditure and fat oxidation observed are particularly intriguing, as they indicate MEAI may boost metabolic rate. This differentiates it from many current weight loss drugs that primarily work by suppressing appetite. However, it's important to note that these are early-stage animal studies and human trials are needed to confirm efficacy and safety.

For investors, this represents a potential new avenue in the lucrative obesity treatment market, but it's important to temper expectations given the early stage of research.

Financial Analyst

The collaboration between SciSparc and Clearmind Medicine represents a strategic partnership in the pharmaceutical industry, combining expertise in cannabinoid-based and psychedelic-derived therapeutics. This approach could potentially accelerate drug development and reduce R&D costs for both companies.

The obesity treatment market is projected to reach $54 billion by 2030, presenting a significant revenue opportunity. However, investors should consider that drug development is a lengthy and costly process with no guarantee of FDA approval. The companies' multiple patent applications could provide future intellectual property protection, potentially enhancing long-term value.

While this news is positive, it's important to note that both SciSparc and Clearmind are clinical-stage companies without marketed products, making them higher-risk investments. Financial stability and cash runway will be important factors to monitor as they progress towards potential commercialization.

SciSparc has been collaborating with Clearmind Medicine to create effective treatments for obesity and metabolic syndrome by combining SciSparc’s Palmitoylethanolamide (PEA) with Clearmind’s MEAI

TEL AVIV, Israel, Aug. 06, 2024 (GLOBE NEWSWIRE) -- SciSparc Ltd. (Nasdaq: SPRC) (the "Company" or "SciSparc"), a specialty clinical-stage pharmaceutical company focusing on the development of therapies to treat disorders and rare diseases of the central nervous system, today announced that a new article published by Baraghithy et al. on the promising results from a recent study on 5-methoxy-2-aminoindane (“MEAI”), Clearmind Medicine Inc’s (Nasdaq: CMND) (“Clearmind” or “Clearmind Medicine”) innovative psychoactive molecule, for combating obesity. The study was meticulously conducted by a team of experts led by Prof. Joseph Tam, head of the Obesity and Metabolism Laboratory at the School of Pharmacy at the Hebrew University of Jerusalem.

This comprehensive study was published in ACS Pharmacology and Translational Science, https://pubs.acs.org/doi/epdf/10.1021/acsptsci.4c00353.

SciSparc and Clearmind have been collaborating since 2022 to develop innovative proprietary combinations for effective and safe treatments for addictions and for obesity and metabolic syndrome. These treatments are based on various combinations therapies including SciSparc’s Palmitoylethanolamide (PEA) and Clearmind’s MEAI. Their joint efforts have led to multiple patent applications aiming to offer safer and more effective therapeutic options. This collaboration leverages Clearmind’s expertise in psychedelic-derived therapeutics and SciSparc’s cannabinoid-based pharmaceutical innovations​. SciSparc and Clearmind jointly fund various studies and IP related to their collaboration.

Key findings from the study demonstrated that the treatment significantly reduced weight loss, in diet-induced obesity in mice, by decreasing fat mass while preserving lean mass. There was a significant improvement in glucose metabolism, increased energy expenditure and fat utilization, while maintaining a similar food consumption and increased activity-specific energy expenditure (without overstimulation), providing support for its potential to impact energy balance. Furthermore, there was a decrease in fatty liver, as evidenced by lower liver triglyceride and cholesterol levels, mainly through inhibiting new lipid synthesis and reducing fat accumulation.

These results further show that a combination treatment was well tolerated and led to increased oxygen consumption and carbon dioxide emission, coupled with elevated energy expenditure and fat oxidation which in turn indicates increases in the metabolic process and fat burn.

About SciSparc Ltd. (Nasdaq: SPRC):

SciSparc Ltd. is a specialty clinical-stage pharmaceutical company led by an experienced team of senior executives and scientists. SciSparc’s focus is on creating and enhancing a portfolio of technologies and assets based on cannabinoid pharmaceuticals. With this focus, the Company is currently engaged in the following drug development programs based on THC and/or non-psychoactive cannabidiol: SCI-110 for the treatment of Tourette Syndrome, for the treatment of Alzheimer's disease and agitation; SCI-160 for the treatment of pain; and SCI-210 for the treatment of autism and status epilepticus. The Company also owns a controlling interest in a subsidiary whose business focuses on the sale of hemp seeds’ oil-based products on the Amazon.com Marketplace.

About Clearmind Medicine Inc.

Clearmind is a clinical-stage psychedelic pharmaceutical biotech company focused on the discovery and development of novel psychedelic-derived therapeutics to solve widespread and underserved health problems, including alcohol use disorder. Its primary objective is to research and develop psychedelic-based compounds and attempt to commercialize them as regulated medicines, foods or supplements.  The Company’s intellectual portfolio currently consists of nineteen patent families including 28 granted patents. The Company intends to seek additional patents for its compounds whenever warranted and will remain opportunistic regarding the acquisition of additional intellectual property to build its portfolio. Shares of Clearmind are listed for trading on Nasdaq under the symbol "CMND" and the Frankfurt Stock Exchange under the symbol “CWY0.”

Forward-Looking Statements:

This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. For example, SciSparc is using forward-looking statements when it discusses potential to create effective treatments for obesity and metabolic syndrome by combining SciSparc’s Palmitoylethanolamide with Clearmind’s MEAI. The Company may not enter into or complete a definitive agreement for the proposed transaction with the biotechnology company or, even if it does, it may not create shareholder value. Since such statements deal with future events and are based on SciSparc’s current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of SciSparc could differ materially from those described in or implied by the statements in this press release. The forward-looking statements contained or implied in this press release are subject to other risks and uncertainties, including those discussed under the heading "Risk Factors" in SciSparc's Annual Report on Form 20-F filed with the SEC on April 1, 2024, and in subsequent filings with the U.S. Securities and Exchange Commission. Except as otherwise required by law, SciSparc disclaims any intention or obligation to update or revise any forward-looking statements, which speak only as of the date they were made, whether as a result of new information, future events or circumstances or otherwise.

Investor Contact:
IR@scisparc.com
Tel: +972-3-6167055

FAQ

What are the key findings of the MEAI study for SPRC stock?

The study showed that MEAI significantly reduced weight loss in obese mice, improved glucose metabolism, increased energy expenditure, decreased fatty liver, and was well-tolerated as a combination treatment. These results suggest potential for SPRC's collaboration with Clearmind Medicine in developing novel weight loss drugs.

How does the SPRC and Clearmind Medicine collaboration work?

SciSparc (SPRC) and Clearmind Medicine have been collaborating since 2022 to develop innovative treatments for addictions, obesity, and metabolic syndrome. They combine SciSparc's Palmitoylethanolamide (PEA) with Clearmind's MEAI, jointly funding studies and IP related to their collaboration.

What is the significance of the MEAI study results for SPRC investors?

The positive results from the MEAI study suggest potential for SPRC in the development of novel weight loss drugs. This could lead to new therapeutic options and potentially valuable patents, which may positively impact SPRC's future market position and stock value.

Where was the MEAI study for SPRC published?

The study on MEAI, relevant to SPRC's collaboration with Clearmind Medicine, was published in ACS Pharmacology and Translational Science on August 6, 2024.