SciSparc Ltd. Ordinary Shares - SPRC STOCK NEWS

SciSparc (Nasdaq: SPRC) has announced the enrollment and dosing of the first five patients in its clinical trial for SCI-210, an innovative treatment for autism spectrum disorder (ASD). The trial, conducted at the Soroka Medical Center in Israel, is a double-blind, randomized, and placebo-controlled study involving 60 subjects aged 5-18 over 20 weeks. SCI-210 combines cannabidiol (CBD) with SciSparc's novel CannAmide™ formulation.

The study aims to compare SCI-210 therapy with standard CBD monotherapy in managing ASD symptoms. Primary efficacy metrics include the ABC-C parent questionnaire, CGI-I clinician assessment, and effective therapeutic dose. Following the trial, SciSparc plans to commercialize SCI-210 in Israel and potentially other countries, subject to regulatory approvals.

SciSparc (Nasdaq: SPRC) has signed an Exclusive Patent License Agreement with Polyrizon for the out-licensing of its SCI-160 program for pain treatment. The deal is valued at $3 million in Polyrizon securities, with potential additional milestone fees of $3 million in cash and royalties. SCI-160 is a proprietary synthetic combination of cannabinoids and N-acylethanolamines that has shown promising results in pre-clinical studies, demonstrating analgesic effects comparable to high-dose morphine without significant side effects. This agreement allows SciSparc to potentially benefit from the program's development without further investment, addressing the need for effective pain treatments amid the opioid abuse crisis.

SciSparc (Nasdaq: SPRC), a specialty clinical-stage pharmaceutical company, has provided an update on its merger agreement with AutoMax Motors The Jerusalem District Court in Israel has approved AutoMax's petition to convene special class meetings of its shareholders to approve the merger with SciSparc. This approval is a important step forward in the merger process.

Additionally, SciSparc has entered into an addendum to the Merger Agreement, extending the right to terminate the agreement if the merger is not consummated. The new deadline has been deferred from August 30, 2024, to November 30, 2024, providing more time for the merger to be completed.

SciSparc (Nasdaq: SPRC) has announced promising results from a study on 5-methoxy-2-aminoindane (MEAI), conducted in collaboration with Clearmind Medicine Inc. (Nasdaq: CMND). The study, published in ACS Pharmacology and Translational Science, demonstrates MEAI's potential as a novel weight loss drug. Key findings include:

• Significant weight loss in diet-induced obese mice
• Improved glucose metabolism and increased energy expenditure
• Decreased fatty liver and reduced fat accumulation
• Well-tolerated combination treatment with elevated metabolic processes

This research is part of SciSparc and Clearmind's ongoing collaboration since 2022, focusing on developing innovative treatments for addictions, obesity, and metabolic syndrome by combining SciSparc's Palmitoylethanolamide (PEA) with Clearmind's MEAI.

SciSparc (Nasdaq: SPRC) announced that its venture, MitoCareX Bio , has validated the potential significant involvement of its target SLC25 carrier protein in Non-Small Cell Lung Cancer (NSCLC) cells. The discovery was demonstrated using genetic manipulations and 3D spheroid systems, mimicking human solid tumors. NSCLC, accounting for 80%-85% of all lung cancer cases globally, is projected to reach a market value of $59.77 billion by 2030.

MitoCareX previously screened millions of small molecules using its proprietary MITOLINE™ algorithm, identifying potential anti-cancer treatments. The company is now working on creating a predictive AI model to more efficiently discover novel anti-cancer small molecule scaffolds targeting its SLC25 protein of interest.

SciSparc (Nasdaq: SPRC) has signed a non-binding letter of intent (LOI) for the exclusive global out-licensing of its SCI-160 pain treatment program. The deal, valued at approximately $6 million, includes:

1. $3 million in ordinary shares and pre-funded warrants of the undisclosed biotechnology company

2. Potential additional payments and execution fees of about $3 million in cash, subject to meeting certain milestones

SCI-160 is a proprietary synthetic cannabinoid formulation that has shown promising results in pre-clinical studies, demonstrating analgesic effects comparable to high-dose morphine without significant side effects. This development aligns with efforts to address the opioid crisis, as prescription opioid-related deaths have increased significantly since 1999.

SciSparc (Nasdaq: SPRC), a clinical-stage pharmaceutical company, has received a notice from Nasdaq indicating non-compliance with the minimum bid price requirement. The company's stock must maintain a minimum bid price of $1.00 per share to remain listed. SciSparc has been granted a 180-day grace period, until January 13, 2025, to regain compliance.

To comply, the closing bid price of SPRC shares must be at least $1.00 for a minimum of ten consecutive business days. If unsuccessful, the company may be eligible for an additional 180-day compliance period. Failure to meet requirements could result in delisting from Nasdaq. The notice does not immediately affect SciSparc's listing or trading of its ordinary shares.

SciSparc (Nasdaq: SPRC) has announced the submission of a new patent application to the USPTO for a novel composition combining Palmitoylethanolamide (PEA), the active ingredient in their CannAmide™ product, with Clearmind Medicine's MEAI compound. This innovative formulation aims to treat metabolic syndrome and obesity.

The patent application is part of an ongoing collaboration with Clearmind Medicine Inc. (Nasdaq: CMND) and was developed in conjunction with Professor Joseph Tam from the Hebrew University. This marks the thirteenth patent application filed under this partnership, targeting various disorders including alcohol use disorder and cocaine addiction.

The obesity treatment market, valued at $15 billion in 2022, is expected to grow at a 10.0% CAGR. With obesity affecting 41.9% of U.S. adults aged 20 and over, this new treatment could address a significant health concern and market opportunity.

SciSparc announced signing a non-binding letter of intent (LOI) to spin off its advanced clinical-stage pharmaceutical portfolio and equity stake in SciSparc Nutraceuticals to Miza III Ventures. Valued at $11.6 million, the assets will be exchanged for 63.3 million Miza shares and up to 48 million contingent rights. The deal's final terms will determine SciSparc's controlling stake in Miza, estimated between 75% and 84.53%. The transaction aligns with SciSparc's strategy to enhance shareholder value and follows a merger agreement with AutoMax Motors. Key portfolio assets include SCI-110 for Tourette syndrome and Alzheimer's disease, and SCI-210 for autism.