Sonnet BioTherapeutics Selected for Poster Presentation at the 2025 AACR IO Conference

Rhea-AI Summary

Sonnet BioTherapeutics (NASDAQ: SONN) announced that its abstract has been accepted for poster presentation at the 2025 American Association for Cancer Research (AACR) IO Conference. The conference will be held from February 23-26, 2025, at the JW Marriott in Los Angeles.

The presentation, scheduled for Tuesday, February 25, 2025 (1:45-4:45 PM PT), will focus on combination immunotherapy with an albumin-binding interleukin-12 fusion protein. The research explores how this protein extends cytokine half-life, targets the tumor microenvironment, and enhances therapeutic efficacy.

PRINCETON, N.J., Feb. 18, 2025 (GLOBE NEWSWIRE) -- Sonnet BioTherapeutics Holdings, Inc. (the “Company” or “Sonnet”) (NASDAQ: SONN), a clinical-stage company developing targeted immunotherapeutic drugs, today announced its abstract has been accepted for poster presentation at the 2025 American Association for Cancer Research (AACR) IO Conference taking place on February 23-26, 2025 at the JW Marriott in Los Angeles, CA.

Details of the poster presentation are as follows:

Session: Poster Session B
Abstract title: Combination immunotherapy with an albumin-binding interleukin-12 fusion protein that extends cytokine half-life, targets the tumor microenvironment, and enhances therapeutic efficacy
Session Date and Time: Tuesday, February 25, 2025 from 1:45-4:45 PM PT

For more information about the conference, please visit the event website.

About Sonnet BioTherapeutics Holdings, Inc.

Sonnet is an oncology-focused biotechnology company with a proprietary platform for developing targeted biologic drugs with single or bifunctional action. Known as F_HAB (Fully Human Albumin-Binding), the technology utilizes a fully human single chain antibody fragment (scFv) that binds to and "hitch-hikes" on human serum albumin (HSA) for transport to target tissues. Sonnet's F_HAB was designed to specifically target tumor and lymphatic tissue, with an improved therapeutic window for optimizing the safety and efficacy of immune modulating biologic drugs. F_HAB platform is the foundation of a modular, plug-and-play construct for potentiating a range of large molecule therapeutic classes, including cytokines, peptides, antibodies, and vaccines.

Sonnet’s lead program, SON-1010, or IL-12-F_HAB, is in development for the treatment of advanced solid tumors, certain types of sarcoma, and platinum-resistant ovarian cancer (PROC). SON-1010 is being evaluated in an ongoing Phase 1/2a study through a Master Clinical Trial and Supply Agreement with Roche in combination with atezolizumab (Tecentriq^®) for the treatment of PROC. The Company is also evaluating its second product candidate, SON-1210, an IL12-F_HAB-IL15 for solid tumors, in collaboration with the Innovative Immuno-Oncology Consortium (IIOC), and plans to commence an investigator-initiated and funded Phase 1/2a study for the treatment of locally-advanced or metastatic pancreatic ductal adenocarcinoma (PDAC).

The Company’s SON-080 program is a low dose of rhIL-6 in development for Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Diabetic Peripheral Neuropathy (DPN). SON-080 demonstrated encouraging results in a Phase 1b/2a clinical trial, being well tolerated with no evidence of a pro-inflammatory cytokine response. In October 2024, Sonnet announced a license agreement with Alkem Laboratories, Inc. who will assume responsibility for advancing development of the SON-080 program into a Phase 2 study in DPN in India.

Forward-Looking Statements

This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section21E of the Securities Exchange Act of 1934 and Private Securities Litigation Reform Act, as amended, including those relating to the Company's cash runway, the Company's product development, clinical and regulatory timelines, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities and other statements that are predictive in nature. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management's current beliefs and assumptions.

These statements may be identified by the use of forward-looking expressions, including, but not limited to, "expect," "anticipate," "intend," "plan," "believe," "estimate," "potential, "predict," "project," "should," "would" and similar expressions and the negatives of those terms. These statements relate to future events or our financial performance and involve known and unknown risks, uncertainties, and other factors which may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Such factors include those set forth in the Company's filings with the Securities and Exchange Commission. Prospective investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this press release. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise.

Investor Relations Contact:

JTC Team, LLC
Jenene Thomas
908-824-0775
SONN@jtcir.com

FAQ

What will Sonnet BioTherapeutics (SONN) present at the 2025 AACR IO Conference?

Sonnet will present research on combination immunotherapy with an albumin-binding interleukin-12 fusion protein, focusing on its ability to extend cytokine half-life, target tumor microenvironment, and enhance therapeutic efficacy.

When and where is Sonnet BioTherapeutics (SONN) presenting at the 2025 AACR IO Conference?

Sonnet will present on Tuesday, February 25, 2025, from 1:45-4:45 PM PT at the JW Marriott in Los Angeles, CA.

What is the focus of Sonnet BioTherapeutics' (SONN) research being presented at AACR 2025?

The research focuses on combination immunotherapy using an albumin-binding interleukin-12 fusion protein that extends cytokine half-life and targets the tumor microenvironment.

Which scientific conference has accepted Sonnet BioTherapeutics' (SONN) abstract for presentation in 2025?

The American Association for Cancer Research (AACR) IO Conference has accepted Sonnet's abstract for poster presentation in February 2025.