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Synaptogenix - SNPX STOCK NEWS

Welcome to our dedicated page for Synaptogenix news (Ticker: SNPX), a resource for investors and traders seeking the latest updates and insights on Synaptogenix stock.

Overview

Synaptogenix Inc (SNPX) is a clinical-stage biopharmaceutical company dedicated to the development of innovative therapeutics for neurodegenerative disorders. Combining rigorous clinical research methodologies with advanced drug discovery techniques, Synaptogenix is renowned for its pioneering work with bryostatin-based therapies. With a product platform built around bryostatin, a small molecule activator of protein kinase C (PKC) enzymes, the company is addressing critical challenges in the management of Alzheimer's disease and various cognitive impairments. Keywords such as clinical-stage, biopharmaceutical, and neurodegenerative disorders underscore its focused expertise in translating novel scientific insights into potential therapeutic solutions.

Core Science and Therapeutic Focus

The core proposition of Synaptogenix lies in harnessing the regenerative and neuroprotective properties of bryostatin. This compound works by activating PKC enzymes that are essential for maintaining synaptogenesis, neural plasticity, and overall synaptic health. The company has conducted extensive clinical and preclinical studies in Alzheimer's disease, demonstrating bryostatin's potential to modulate synaptic function and counteract neurodegeneration. Additionally, preclinical testing suggests that bryostatin may have applications in other neurodegenerative and cognitive conditions, including Fragile X syndrome, multiple sclerosis, and traumatic brain injury.

Clinical Programs and Research Initiatives

Synaptogenix follows a diversified clinical research strategy that encompasses multiple therapeutic areas. Its lead candidate, bryostatin-1, has undergone clinical testing in the context of Alzheimer's disease, and the company is exploring its benefits across several other indications. Notably, the investigation into bryostatin for multiple sclerosis employs state-of-the-art imaging modalities, such as 7-tesla MRI, to establish robust biomarkers for assessing treatment efficacy. This multidisciplinary approach is designed to harness a broad safety database and leverage insight from over 1,500 cancer study participants originally involved in bryostatin trials, thereby strengthening the scientific rationale behind its clinical applications.

Scientific Collaborations and Partnerships

Recognizing the inherent challenges of drug development in a regulated environment, Synaptogenix has entered into several strategic partnerships. Collaborations with esteemed academic and research institutions enhance its capability to conduct preclinical studies and refine therapeutic hypotheses. For instance, its recent partnership with a neuroscience center of excellence is aimed at assessing polyunsaturated fatty acid (PUFA) analogs as potential treatments for spinal cord injuries. Similarly, a collaborative relationship with a partner specializing in cannabis-based therapeutic research explores the de-risking of drug discovery through advancements in regulatory science. These partnerships not only expand the company's research capabilities but also integrate specialized expertise in analytical drug development and biomarker identification.

Regulatory and Clinical Validation

In a sector defined by stringent regulatory scrutiny, Synaptogenix overlays its scientific programs with robust experimental design and regulatory compliance. The company has secured Orphan Drug Designation for bryostatin-1 in the treatment of Fragile X syndrome, which validates its potential in addressing rare and underexplored neurodegenerative conditions. Rigorous clinical trial designs, complemented by academic partnerships and advanced imaging technologies, provide a framework to carefully assess both efficacy and safety. This approach is emblematic of the company's commitment to patient safety and scientific integrity, reinforcing its reputation within the clinical research community.

Market Position and Business Model

Positioned at the intersection of innovative science and clinical application, Synaptogenix operates within the high-stakes realm of novel therapeutic development. Its business model is built on the foundation of progressive clinical trials, strategic financing rounds, and key partnerships with leading research institutions. While the company navigates the complexities of drug development funding and regulatory compliance, it continually advances research through diversified clinical studies and collaborations. The emphasis on robust clinical validations reduces uncertainty and enhances the credibility of its therapeutic approach, ultimately aiming to address unmet medical needs associated with neurodegenerative disorders.

Intellectual Property and Pipeline Diversification

A strong intellectual property portfolio underpins Synaptogenix's innovative work, with patents protecting the use of both bryostatin and related therapeutic candidates. The company's commitment to research extends beyond its lead candidate—exploratory studies on cannabinoid-based and PUFA analog therapies represent a broader strategy to diversify its pipeline. Such diversification demonstrates a forward-thinking approach to drug discovery, ensuring that its scientific pursuits remain comprehensive and adaptable to emerging clinical trends.

Conclusion

Synaptogenix represents a methodically developed, research-intensive biopharmaceutical entity with a clear commitment to redefining therapeutic strategies for neurodegenerative diseases. Through its rigorous clinical programs, strategic scientific collaborations, and an in-depth focus on regenerative medicine, the company presents a detailed blueprint of advanced drug development. Its scientifically robust and diversified research initiatives continue to inform both clinical trial design and potential market opportunities, making Synaptogenix a pivotal player in the realm of clinical-stage therapeutic development for disorders that significantly impact cognitive and neurological functions.

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Synaptogenix announces statistically significant benefits of Bryostatin-1 in severe Alzheimer's disease patients, with no significant cognitive decline in the 10-month trial compared to placebo patients. The data suggests a long-lasting positive change in treated patients' brains. The company believes Bryostatin-1 could provide a complementary treatment option for advanced-stage Alzheimer's patients.
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Synaptogenix, Inc. (SNPX) Announces Positive Findings in ALS Study
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Synaptogenix announces collaboration with Cleveland Clinic for phase 1 trial of Bryostatin-1 in MS. The trial will evaluate the drug's potential neuro-restorative mechanism(s) of action for improving synaptic health and cognitive function in MS patients.
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Synaptogenix, Inc. announced that the abstract featuring secondary endpoint data of its Phase 2 Bryostatin-1 trial was accepted for presentation at the 11th International Brain Research Organization World Congress of Neuroscience. The trial showed significant benefits for patients in the Severe Cohort with advanced Alzheimer's disease, while the Moderate Cohort showed no significant benefit. The company believes that Bryostatin-1 can prevent cognitive decline in advanced AD patients.
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Synaptogenix, Inc. (SNPX) reported promising secondary endpoint results from an NIH-sponsored Phase 2 clinical trial of Bryostatin-1 in advanced Alzheimer's disease patients. The company has approximately $37.5 million in cash as of December 31, 2022, maintaining a robust financial position. The Phase 2 trial results showed statistical significance in secondary endpoints for the most severe Alzheimer's patient population (MMSE-2 scores of 10-14), indicating potential efficacy. Synaptogenix aims to explore acquisition opportunities and continue collaborations with strategic partners to enhance shareholder value.

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Synaptogenix, Inc. (Nasdaq: SNPX) announced topline results from its NIH-sponsored Phase 2 clinical trial of Bryostatin-1 for advanced Alzheimer's disease. The trial failed to meet its primary endpoint, showing an average increase in the Severe Impairment Battery (SIB) score of only 1.4 points for the treatment group compared to 0.6 points for the placebo group at week 28. CEO Alan Tuchman expressed disappointment and indicated a review of the trial data to determine next steps. The company remains well-capitalized, holding approximately $38.5 million in cash as of December 15, 2022.

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Synaptogenix has announced a private placement financing raising approximately $15 million through convertible redeemable preferred stock and warrants from existing investors. This financing is set to close on November 21, 2022, enhancing the company's balance sheet ahead of expected Phase 2 clinical trial results for Alzheimer's disease this December. The preferred stock has a conversion price of $7.75 per share, representing a 25% premium to the previous closing price, and warrants for 1,935,485 additional shares. The company plans to file a registration statement with the SEC for the resale of shares.

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Synaptogenix, a biopharmaceutical company focused on neurodegenerative disorders, is set to present at the ThinkEquity Conference on October 26, 2022, at the Mandarin Oriental Hotel in New York. Dr. Daniel L. Alkon, President and Chief Scientific Officer, will discuss the company's NIH-supported Phase 2 clinical trial of Bryostatin-1 for treating advanced Alzheimer's disease. Topline data from this trial is expected in the current quarter. The company aims to develop therapies that improve Alzheimer's patients' conditions and prevent disease progression.

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Synaptogenix, Inc. (Nasdaq: SNPX) announced that it anticipates results from its Phase 2 clinical trial of Bryostatin-1 for advanced Alzheimer's disease in Q4 2022. The company highlights its commitment to restoring cognitive function, contrasting its approach with Biogen and Eisai's method of slowing disease progression. Bryostatin-1 aims to regenerate synaptic networks, potentially leading to improved cognitive performance. The lead compound has been previously tested in over 1,500 individuals, providing a strong safety database to guide future clinical trials.

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Synaptogenix, Inc. (Nasdaq: SNPX) announced that Dr. Daniel L. Alkon, President and CSO, will appear on TD Ameritrade Network's "Trading 360" on August 12, 2022, at 10:30 AM Eastern. Dr. Alkon will discuss the advancement of treatments for Alzheimer's disease and the Phase 2b clinical trial of the lead drug, Bryostatin-1. Synaptogenix holds Orphan Drug Designation for Bryostatin-1 for treating Fragile X syndrome. The Company emphasizes ongoing clinical developments and the potential future applications of Bryostatin-1 in neurodegenerative diseases.

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FAQ

What is the current stock price of Synaptogenix (SNPX)?

The current stock price of Synaptogenix (SNPX) is $2.4323 as of April 1, 2025.

What is the market cap of Synaptogenix (SNPX)?

The market cap of Synaptogenix (SNPX) is approximately 3.2M.

What is the primary focus of Synaptogenix?

Synaptogenix is primarily focused on developing novel therapeutics for neurodegenerative disorders, with a strong emphasis on its bryostatin-based drug candidate.

How does Synaptogenix approach drug development?

The company employs a rigorous clinical research strategy that includes both clinical and preclinical trials, along with strategic partnerships with academic and research institutions to validate its findings.

What makes bryostatin a critical component of their pipeline?

Bryostatin is a small molecule that activates protein kinase C enzymes, which are vital for maintaining synaptic health and have shown promise in mitigating neurodegenerative processes in conditions like Alzheimer's disease.

Are there other therapeutic areas the company is exploring?

Yes, apart from Alzheimer's disease, Synaptogenix is investigating the potential of bryostatin and related compounds for conditions such as multiple sclerosis, Fragile X syndrome, and even spinal cord injuries.

How does Synaptogenix strengthen its research capabilities?

The company collaborates with leading academic centers and research institutes, enhancing its clinical trial designs and leveraging advanced imaging and biomarker technologies to assess therapeutic efficacy.

What role does intellectual property play for Synaptogenix?

Intellectual property is crucial for Synaptogenix; the company holds patents for its novel compounds and therapies, which helps protect its innovations and supports a diversified pipeline of therapeutic candidates.

How is Synaptogenix positioned within the competitive biopharma landscape?

Synaptogenix differentiates itself through its advanced scientific research, robust clinical trial methodologies, and strategic partnerships, all of which underpin its focused approach to treating neurodegenerative disorders.
Synaptogenix

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