Silence Therapeutics Reports Full-year 2020 Results
Silence Therapeutics, trading under the symbol SLN, published its audited full-year results for 2020, showcasing substantial advancements in its mRNAi GOLD™ platform.
Significant developments include the initiation of Phase 1 studies for SLN360 and SLN124, with SLN360 receiving FDA IND approval. Financially, the company ended 2020 with £37.4m in cash and raised $45m in funding. A pivotal collaboration with AstraZeneca yielded an upfront payment of $20m, with potential future milestones up to $400m. Silence aims to deliver 2-3 INDs annually starting in 2023, underlining its commitment to innovation.
- SLN360 received FDA IND approval, enabling the start of the APOLLO Phase 1 study.
- Collaboration with AstraZeneca included a $20m upfront payment and potential milestones of up to $400m.
- Appointed key personnel to bolster leadership and expertise.
- Strengthened financial position with £37.4m in cash and a $45m capital raise.
- Operating loss for 2020 was £35.8m, compared to £22.7m in 2019, indicating increased expenses.
Silence Therapeutics Reports Full-year 2020 Results
Advancing clinical programmes; On-track for three phase 1 data readouts in 2021
30 March 2021
LONDON, Silence Therapeutics plc, AIM: SLN and Nasdaq: SLN (“Silence” or “the Company”), a leader in the discovery, development and delivery of novel short interfering ribonucleic acid (siRNA) therapeutics for the treatment of diseases with significant unmet medical need, announced its audited full year results for the year ended 31 December 2020.
Mark Rothera, President and CEO of Silence Therapeutics, commented: “2020 was a transformational year for Silence Therapeutics, driven by the remarkable resilience of our people in what was a challenging year for the world. We have made significant progress with our mRNAi GOLD™ platform, with both lead programmes now in the clinic and three data readouts due this year. Alongside advancing our wholly owned pipeline, we continue to progress our high-value partnerships and through this two-pronged approach, our goal is to deliver 2-3 INDs per year from 2023. We are well positioned for success and motivated by our vision to transform people’s lives through our precision engineered medicines.”
Craig Tooman, CFO of Silence Therapeutics, commented: “Silence ended 2020 in a strong financial position, driven by non-dilutive funding from our collaborations. Our balance sheet has been further strengthened by the recent
Operational Highlights
- Advanced both wholly owned product candidates, SLN360 for cardiovascular disease due to high Lipoprotein(a), or Lp(a) levels and SLN124 for thalassaemia and myelodysplastic syndrome (MDS).
- SLN360 received approval of an initial drug application (IND) by the FDA and Silence initiated the APOLLO Phase 1 study in people with high Lp(a) levels.
- SLN124 was granted rare paediatric disease designation for thalassaemia as well as orphan drug designations for MDS and thalassaemia by the FDA.
- Initiated the GEMINI Phase 1 study of SLN124 in healthy volunteers.
- Secured a significant collaboration deal with AstraZeneca to discover and develop siRNA therapeutics for up to 10 targets in cardiovascular, renal, metabolic and respiratory diseases.
- Upfront cash payment of
$20m was received and another$40m is due in the first half of 2021. - Deal economics include up to
$400m in milestone payments and royalties for each programme.
- Upfront cash payment of
- Expanded RNAi collaboration with Mallinckrodt for complement-mediated diseases with Mallinckrodt exercising options to license two additional targets from Silence, bringing the total to the maximum three programmes envisaged in the collaboration deal.
- Commenced a technology evaluation with Takeda to explore the potential of using Silence’s mRNAi GOLD™ platform against a novel, undisclosed target.
- Appointed Dr Giles Campion as Executive Director, Dr Marie Wikström Lindholm as Senior Vice President, Molecular Design, Dr Eric Floyd as Senior Vice President, Head of Global Regulatory Affairs and Quality Assurance and Dr Barbara Ruskin as Senior Vice President, General Counsel and Chief Patent Officer.
- Launched a Scientific Advisory Board comprising world-leading scientists and clinicians to support the optimisation of Silence’s mRNAi GOLD™ platform and guide development strategies for SLN360 and SLN124.
- Completed U.S. listing and our American Depository Shares (ADSs) began trading on the Nasdaq Capital Market (Nasdaq) under the symbol “SLN” on 8 September 2020.
- Appointed Mark Rothera as our President, Chief Executive Officer and Board member.
Financial Highlights
- Cash and cash equivalents and term deposits of
£37.4m at year-end (2019:£33.5m ). The Group had£97.5m on a proforma basis, which includes£37.4m at year-end, plus the£29.3m ($40m ) receivable from AstraZeneca due in the first half of 2021, plus net proceeds of£30.8m from the February 2021 capital raise. - Cash flow from operating activities was
£10.8m outflow (2019:£1.7m inflow) against an operating loss of£35.8m (2019:£22.7m ). 2020 included receipts of$20m upfront from AstraZeneca,$2.0m in milestones from Mallinckrodt Pharmaceuticals, and a$2.0m upfront from Takeda. - 2020 loss was higher primarily due to increased research and development spend in relation to our SLN360 and SLN124 proprietary programmes, as well as general and administrative expenses mainly relating to the Nasdaq listing.
Post Year-end
- Appointed Dr Michael H. Davidson to the Silence Board of Directors as a Non-Executive Director and Craig Tooman to the Executive Leadership Team as Chief Financial Officer.
- Completed an oversubscribed
$45m (c.£33m ) private placement led by top-tier US institutional healthcare funds. - Initiated dosing in the APOLLO Phase 1 study of SLN360 in people with high Lp(a) levels.
- Initiated work with Mallinckrodt on the third complement target which triggered a
$2.0m research milestone payment to Silence. - Completed enrolment in the GEMINI Phase 1 study of SLN124 in healthy volunteers.
- Initiated the GEMINI II Phase 1b study of SLN124 in people with thalassemia and MDS.
Enquiries:
| Silence Therapeutics plc Gem Hopkins, Head of IR and Corporate Communications ir@silence-therapeutics.com | Tel: +1 (646) 637-3208 |
| Investec Bank plc (Nominated Adviser and Broker) Daniel Adams/Gary Clarence | Tel: +44 (0) 20 7597 5970 |
| European PR Consilium Strategic Communications Mary-Jane Elliott/ Angela Gray / Chris Welsh silencetherapeutics@consilium-comms.com | Tel: +44 (0) 20 3709 5700 |
About Silence Therapeutics
Silence Therapeutics is developing a new generation of medicines by harnessing the body's natural mechanism of RNA interference, or RNAi, to inhibit the expression of specific target genes thought to play a role in the pathology of diseases with significant unmet medical need. Silence's proprietary messenger RNAi GOLD™ platform can be used to create siRNAs that precisely target and silence disease-associated genes in the liver, which represents a substantial opportunity. Silence's wholly owned product candidates include SLN360 designed to address the high and prevalent unmet medical need in reducing cardiovascular risk in people born with high levels of lipoprotein(a) and SLN124 designed to address iron loading anemias. Silence also maintains ongoing research and development collaborations with AstraZeneca, Mallinckrodt Pharmaceuticals, and Takeda, among others. For more information, please visit https://www.silence-therapeutics.com/.
Forward-Looking Statements
Certain statements made in this announcement are forward-looking statements, including with respect to the Company's clinical and commercial prospects. These forward-looking statements are not historical facts but rather are based on the Company's current expectations, estimates, and projections about its industry; its beliefs; and assumptions. Words such as 'anticipates,' 'expects,' 'intends,' 'plans,' 'believes,' 'seeks,' 'estimates,' and similar expressions are intended to identify forward-looking statements. These statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties, and other factors, some of which are beyond the Company's control, are difficult to predict, and could cause actual results to differ materially from those expressed or forecasted in the forward-looking statements. The Company cautions security holders and prospective security holders not to place undue reliance on these forward-looking statements, which reflect the view of the Company only as of the date of this announcement. The forward-looking statements made in this announcement relate only to events as of the date on which the statements are made. The Company will not undertake any obligation to release publicly any revisions or updates to these forward-looking statements to reflect events, circumstances, or unanticipated events occurring after the date of this announcement except as required by law or by any appropriate regulatory authority.
Conference Call
Company management will host a live webcast to discuss its 2020 annual results and recent business performance today at 8:00 a.m. EDT / 13:00 BST.
Dial-in details are:
Webcast link: https://edge.media-server.com/mmc/p/odvo7f8f
Participant UK dial-in: +44 2071 928338
Participant US dial-in: +1 646 741 3167
Conference ID: 3094621
A presentation to accompany the call will be made available to download from; https://www.silence-therapeutics.com/investors/results-reports-presentations
Chairman’s Statement
That was the year that was….
As I write this, we are still in the midst of the COVID-19 pandemic. No business has been left untouched by the impact of the virus, and at Silence Therapeutics, we have effectively taken all necessary steps to reduce the potential negative impact on our business. Most importantly, our priority in the current situation has been to ensure the well-being and safety of our employees, patients, and partners, whilst conscientiously safeguarding the interests of you, our shareholders. Accordingly, we have taken the necessary precautions and we will continue to monitor the spread of the virus and implement subsequent actions carefully so the business is in its strongest possible position to maximise the opportunity when the international vaccination programmes are rolled out and restrictions are finally lifted. During the period under review, our employees have done an amazing job to maintain the integrity of our business despite the unprecedented conditions.
The pace has quickened….
In last year’s Annual Report, I made it clear I thought that “Silence had come of age”. This was clearly demonstrated in the second half of 2019 and throughout 2020 and I can confirm the pace has quickened. We have made significant progress across all facets of the business as outlined in this year’s CEO’s Report. Notably, our R&D organisation and capabilities have been significantly strengthened and the development of our potentially world-class clinical assets progressed. Independently and together with our business partners, we have ongoing clinical trials and clinical trials planned to start. However, we recognise that global measures against COVID-19 and the need to prioritise health care resources have undoubtedly affected the timelines of these studies. As a result, we have put in place contingency measures and although the timing of the initial results from clinical studies may be affected, we remain confident that in 2021 we are well placed to expediently progress our wholly owned SLN360 and SLN124 programmes and our partnered programmes and achieve significant clinical milestones.
During the year we have concluded additional pivotal partnering agreements with big pharma including AstraZeneca, and also with biotech and academic groups and thereby not only accessed capabilities and assets but also considerably strengthened our balance sheet by securing further non-dilutive funding. In parallel, as we have achieved further clinical and regulatory milestones for each of our wholly owned programmes, there has been a growing excitement amongst researchers, clinicians, patient groups and further potential partners.
A competent and cohesive team is now in place……
During the year we opened our office in New York and listed on Nasdaq and made further key management appointments across the organisation. In September 2020 we appointed our new CEO, Mark Rothera, who brings the experience we need to capitalise on the progress to date and to build the business going forward. Despite the backcloth of COVID-19, in 2020, Silence Therapeutics was designated a Great Place to Work both in the UK and Germany, which is a further testament to our management and employees with their high level of competence and commitment.
Governance….
We remain committed to high standards of governance and continue to comply with the regulatory standards required of an AIM listed and Nasdaq foreign private issuer (“FPI”) company. Also, we are committed to an effective control environment to maintain high standards throughout the Company. In addition to appointing our new CEO, during the year we invited Dr Giles Campion, Head of R&D and CMO to join the Board as an Executive Director to ensure R&D remains at the front and centre of our thinking. Post period we further strengthened the Board with the appointment of Dr Michael Davidson as Non-Executive Director. Michael brings relevant clinical experience in the cardiovascular sector and also an extensive background in the US biotech sector.
Outlook – it is now about execution….
This past year has not been without its challenges, but with the continued support of our major shareholders and the dedication of a highly resilient and focused management team, I am confident by executing on our strategy in relation to our pipeline delivery, portfolio focus, geographic expansion and commercial goals that we now have the momentum, and ability to deliver on our ambitious targets for 2021 and beyond.
On behalf of the business, I want to extend our thanks to all our stakeholders, shareholders, partners and suppliers, who have supported the business over the past year. As a final word, I would like to share my sincere thanks to our employees for their hard work and commitment in 2020. With their dedication and determination, we have navigated a transformational journey, and during the COVID-19 era, which has enabled us to achieve our goals for the Company while setting a foundation to deliver long-term advantage. I am proud of their achievements and look forward to working with them on the next stage of our journey in 2021.
Iain Ross
Chairman
Chief Executive Officer’s Report
2020 was a transformational year for Silence, highlighted by remarkable scientific and corporate progress. After 20 years of developing our science in the field of RNAi, we enter 2021 as a clinical-stage company with three Phase 1 data readouts anticipated this year. Since joining the Company in September 2020, I have been immensely impressed with our innovative science, unparalleled know-how and the dedication of our team. I believe Silence is poised for substantial growth and our team is focused on strong execution with a clear near-term path to value creation.
Exceptional progress…
Silence is showing rapid progress towards realizing our potential with several important milestone achievements in 2020 and this progress has continued at pace in 2021. In 2020, we made significant progress with our proprietary mRNAi GOLD™ (GalNAc OLigonucleotide Discovery) platform, advancing both wholly owned candidates, SLN360 for the high and prevalent unmet need in reducing cardiovascular risk due to high lipoprotein(a) – Lp(a) - levels and SLN124 for rare iron loading anaemia conditions thalassemia and MDS.
In the year, SLN360 received approval of an investigational new drug application (IND) from the FDA and we initiated the APOLLO Phase 1 study in people with high Lp(a), a genetically determined independent cardiovascular risk factor affecting up to
Alongside advancing our wholly owned pipeline, developing high-value collaborations is a core part of our strategy and we made great strides with this in 2020. This included a landmark deal with AstraZeneca for up to 10 programmes, a technology evaluation deal with Takeda for a first programme as well as deepening our collaboration with Mallinckrodt for complement-mediated diseases with Mallinckrodt exercising options on all three programmes covered by the agreement. Collectively these partnerships represent up to 14 programmes and economics of up to
The completion of our Nasdaq listing in September marked a significant step in our efforts to position ourselves more globally and gives us access to an important pool of capital, US biotech investors. Financially, we ended the year with a strong cash position of
The right people…
You can have the best science and technology in the world, but it does not matter if you do not have the right people and culture in place to execute your strategy. At Silence, I believe we have both. We have exceptional experience at every level, including a research and discovery team that has been operating now for 20 years in the RNAi field. In the year, we strengthened our executive leadership team, including appointments such as Dr Giles Campion as Executive Director, Dr Eric Floyd as Senior Vice President, Head of Global Regulatory Affairs and Quality Assurance, Dr Barbara Ruskin as Senior Vice President, General Counsel and Chief Patent Officer and Dr Marie Wikström Lindholm as Senior Vice President, Molecular Design. We also introduced a Scientific Advisory Board comprising world-leading scientists and clinicians to support the optimisation of our mRNAi GOLD™ platform and guide development strategies for SLN360 and SLN124. This momentum has continued into 2021 as we have appointed leading lipidology and cardiovascular clinical trial expert, Dr Michael Davidson, to our Board of Directors and Craig Tooman, an experienced US public biotech company CFO to our leadership team.
A clear path to value creation…
It has taken a number of years for the RNA field to mature, and we have enjoyed watching it soar over the past year, highlighted by the FDA approval of two mRNA-based vaccines for COVID-19. There is more awareness and increasing appreciation for the potential benefits of mRNA-based therapeutics and I believe that Silence is well positioned to capitalise on this attractive market.
Over the years, Silence has built substantial know-how and expertise in the science of RNAi, which has given rise to our mRNAi GOLD™ platform that is now in the clinic. Since I joined Silence, we have conducted a detailed strategic business review and identified three core components of our strategy going forward – all based on our mRNAi GOLD™ platform.
Firstly, we must rapidly and effectively execute on our clinical programmes. We view SLN360 as a key strategic asset as this is a program with blockbuster potential that we own outright. We are hopeful that the strong pre-clinical profile will translate well into the clinic and expect to report data from the ongoing APOLLO Phase 1 study of SLN360 in people with high Lp(a) in the second half of this year. Our plan is to rapidly advance SLN360 in the clinic, positioning ourselves to initiate phase 2 studies in the second half of 2022 while creating more value for the asset and options for the future. With SLN124, we expect data from the ongoing GEMINI Phase 1 study in healthy volunteers in the first half of this year. This study is important because we expect it to validate our preclinical findings that administering SLN124 effectively reduces iron overload by increasing hepcidin levels and it will be the first-in-human data from our mRNAi GOLD™ platform. In parallel, we are evaluating SLN124 in the GEMINI II Phase 1b study in people with thalassemia and MDS and intend to report interim data from the single-ascending dose portion in the second half of this year.
Next, we must ensure that we fully unleash the potential of our mRNAi GOLD™ platform. There are around 14,000 genes expressed in the liver and only around
Finally, we will continue with our hybrid business model, building our wholly owned pipeline while developing partnership programs that allow us to do more with our mRNAi GOLD™ platform. This hybrid approach creates a balance to rapidly grow our pipeline while enabling us to finance our endeavours largely through non-dilutive capital from partnership programmes. We believe this is especially worthwhile given the unusually high probability of success this modality has shown in the clinic amongst RNAi players.
Looking ahead…
I believe that this is our moment. We have deep scientific know-how in the RNAi field, two wholly owned programmes advancing in the clinic, validating partnerships, and a platform technology that is really at the beginning of what it can do. Importantly, we have the right team to drive execution. Our goal now is to effectively accelerate this development and position Silence as a leading global RNAi business.
We are truly motivated by our purpose to transform peoples’ lives around the world through our precision engineered medicines and driving positive change for the communities around us. I look forward to keeping you updated on our progress.
Mark Rothera
Chief Executive Officer
Financial Review
Investment in R&D grew strongly in the year to
Revenue
Revenue recognised for 2020 increased to
Research and Development Expenditure
Research and development spend in the year increased by
Administrative Expenses
General and administration expenses increased by
Other (Losses)/Gains
The Group recognised an expense of
Finance and Other Income
The Group recognised income of
Finance and Other Expenses
The Group recognised an expense of
Taxation
Taxation for 2020 amounted to a credit of
The increase in the credit amount was primarily attributable to our increased expenditure on research and development.
Liquidity, Cash and Cash Equivalents and Term Deposits
The Group’s cash and cash equivalents and term deposits at year end totalled
The cash flow from operating activities was
In 2021, the Group expects to make continued investments in R&D to support its clinical programmes and discovery efforts. The Group also anticipates increased G&A investments compared to FY 2020 to support organisational growth, including its public company needs.
The Directors have reviewed the working capital requirements of the Group and Company for the twelve months from signing these financial statements and are confident that these can be met from existing funds, which also takes into account the
Other Balance Sheet Items
Current trade and other payables increased by
Craig Tooman
Chief Financial Officer
Consolidated income statement
year ended 31 December 2020
| 2020 | 2019 | |||||||||||
| Revenue | 5,479 | 244 | ||||||||||
| Cost of sales | (3,762 | ) | - | |||||||||
| Gross (loss) / profit | 1,717 | 244 | ||||||||||
| Research and development costs | (20,209 | ) | (13,336 | ) | ||||||||
| Administrative expenses | (13,983 | ) | (9,642 | ) | ||||||||
| Other (losses)/gains - net | (3,372 | ) | - | |||||||||
| Operating loss | (35,847 | ) | (22,734 | ) | ||||||||
| Finance and other expenses | (323 | ) | (163 | ) | ||||||||
| Finance and other income | 129 | 27 | ||||||||||
| Loss for the year before taxation | (36,041 | ) | (22,870 | ) | ||||||||
| Taxation | 3,494 | 3,288 | ||||||||||
| Loss for the year after taxation | (32,547 | ) | (19,582 | ) | ||||||||
| Loss per ordinary equity share (basic and diluted) | (39.8 | ) pence | (26.1 | ) pence | ||||||||
Consolidated statement of comprehensive income
year ended 31 December 2020
| 2020 | 2019 | |||||||
| Loss for the year after taxation | (32,547 | ) | (19,582 | ) | ||||
| Other comprehensive expense, net of tax: | ||||||||
| Items that may subsequently be reclassified to profit and loss: | ||||||||
| Foreign exchange differences arising on consolidation of foreign operations | 472 | (411 | ) | |||||
| Total other comprehensive income/(expense) for the year | 472 | (411 | ) | |||||
| Total comprehensive expense for the year | (32,075 | ) | (19,993 | ) | ||||
Consolidated balance sheet
at 31 December 2020
| December 31, | ||||||||||||
| 2020 | 2019 | |||||||||||
| Non-current assets | ||||||||||||
| Property, plant and equipment | 1,127 | 611 | ||||||||||
| Goodwill | 8,125 | 7,692 | ||||||||||
| Other intangible assets | 17 | 34 | ||||||||||
| Financial assets at amortised cost | 303 | 275 | ||||||||||
| 9,572 | 8,612 | |||||||||||
| Current assets | ||||||||||||
| Cash and cash equivalents | 27,449 | 13,515 | ||||||||||
| Derivative financial instrument | 1,492 | - | ||||||||||
| Financial assets at amortised cost – term deposit | 10,000 | 20,000 | ||||||||||
| Financial asset at amortised cost – other | - | 1 | ||||||||||
| R&D tax credit receivable | 3,536 | 3,060 | ||||||||||
| Other current assets | 4,616 | 885 | ||||||||||
| Trade receivables | 29,306 | 4 | ||||||||||
| 76,399 | 37,465 | |||||||||||
| Non-current liabilities | ||||||||||||
| Contract liabilities | (51,337 | ) | (15,515 | ) | ||||||||
| (51,337 | ) | (15,515 | ) | |||||||||
| Current liabilities | ||||||||||||
| Contract liabilities | (17,042 | ) | (2,478 | ) | ||||||||
| Trade and other payables | (8,192 | ) | (6,888 | ) | ||||||||
| Lease liability | (341 | ) | (287 | ) | ||||||||
| (25,575 | ) | (9,653 | ) | |||||||||
| Net assets | 9,059 | 20,909 | ||||||||||
| Capital and reserves attributable to the owners of the parent | ||||||||||||
| Share capital | 4,165 | 3,919 | ||||||||||
| Capital reserves | 186,891 | 167,243 | ||||||||||
| Translation reserve | 2,218 | 1,746 | ||||||||||
| Accumulated losses | (184,215 | ) | (151,999 | ) | ||||||||
| Total shareholders equity | 9,059 | 20,909 | ||||||||||
Consolidated statement of changes in equity
year ended 31 December 2020
| Share capital | Capital reserves | Translation reserve | Accumulated losses | Total equity | ||||||||||||||||||
| At January 1, 2019 | 3,554 | 163,121 | 2,157 | (133,787 | ) | 35,045 | ||||||||||||||||
| Recognition of share-based payments | - | 584 | - | - | 584 | |||||||||||||||||
| Options exercised in the year | - | (1,370 | ) | - | 1,370 | - | ||||||||||||||||
| Proceeds from shares issued | 365 | 4,908 | - | - | 5,273 | |||||||||||||||||
| Transactions with owners recognised directly in equity | 365 | 4,122 | - | 1,370 | 5,857 | |||||||||||||||||
| Loss for year | - | - | - | (19,582 | ) | (19,582 | ) | |||||||||||||||
| Other comprehensive expense | ||||||||||||||||||||||
| Foreign exchange differences arising on consolidation of foreign operations | - | - | (411 | ) | - | (411 | ) | |||||||||||||||
| Total comprehensive expense for the year | - | - | (411 | ) | (19,582 | ) | (19,993 | ) | ||||||||||||||
| At December 31, 2019 | 3,919 | 167,243 | 1,746 | (151,999 | ) | 20,909 | ||||||||||||||||
| Recognition of share-based payments | - | 4,395 | - | - | 4,395 | |||||||||||||||||
| Options exercised in the year | - | (331 | ) | - | 331 | - | ||||||||||||||||
| Proceeds from shares issued | 246 | 15,584 | - | - | 15,830 | |||||||||||||||||
| Transactions with owners recognised directly in equity | 246 | 19,648 | - | 331 | 20,225 | |||||||||||||||||
| Loss for year | - | - | - | (32,547 | ) | (32,547 | ) | |||||||||||||||
| Other comprehensive income | - | |||||||||||||||||||||
| Foreign exchange differences arising on consolidation of foreign operations | - | - | 472 | - | 472 | |||||||||||||||||
| Total comprehensive expense for the year | - | - | 472 | (32,547 | ) | (32,075 | ) | |||||||||||||||
| At December 31, 2020 | 4,165 | 186,891 | 2,218 | (184,215 | ) | 9,059 | ||||||||||||||||
Consolidated statement of cash flows
year ended 31 December 2020
| Year ended December 31, | ||||||||
| 2020 | 2019 | |||||||
| Cash flow from operating activities | ||||||||
| Loss before tax | (36,041 | ) | (22,870 | ) | ||||
| Depreciation charges | 476 | 452 | ||||||
| Amortisation charges | 20 | 30 | ||||||
| Charge for the year in respect of share-based payments | 4,395 | 584 | ||||||
| Net foreign exchange loss | 4,864 | - | ||||||
| Gain on derivative financial instrument | (1,492 | ) | - | |||||
| Finance and other expenses | 323 | 163 | ||||||
| Finance and other income | (129 | ) | (27 | ) | ||||
| (Gain)/loss on disposal of property, plant and equipment | (3 | ) | 2 | |||||
| Revaluation of trade and other receivables related to contract liabilities | (4,864 | ) | - | |||||
| Decrease in trade and other receivables | (29,302 | ) | (4 | ) | ||||
| Increase in other current assets | (3,731 | ) | (4 | ) | ||||
| Decrease in current financial assets at amortised cost – other | 1 | 42 | ||||||
| Increase in trade and other payables | 1,303 | 3,058 | ||||||
| Increase in contract liabilities | 50,386 | 17,993 | ||||||
| Cash spent on operations | (13,794 | ) | (581 | ) | ||||
| R&D tax credits received | 3,018 | 2,308 | ||||||
| Net cash (outflow)/inflow from operating activities | (10,776 | ) | 1,727 | |||||
| Cash flow from investing activities | ||||||||
| Net redemption/(purchase) of financial assets at amortised cost – term deposits | 10,000 | (15,000 | ) | |||||
| Interest received/(paid) | 129 | (6 | ) | |||||
| Purchase of property, plant and equipment | (511 | ) | (9 | ) | ||||
| Purchase of intangible assets | (3 | ) | - | |||||
| Proceeds from sale of property, plant and equipment | 3 | - | ||||||
| Net cash inflow/(outflow) from investing activities | 9,618 | (15,015 | ) | |||||
| Cash flow from financing activities | ||||||||
| Repayment of lease liabilities | (402 | ) | - | |||||
| Proceeds from issue of share capital | 15,830 | 5,273 | ||||||
| Net cash inflow from financing activities | 15,428 | 5,273 | ||||||
| Increase/(decrease) in cash and cash equivalents | 14,270 | (8,015 | ) | |||||
| Cash and cash equivalents at start of year | 13,515 | 21,494 | ||||||
| Effect of exchange rate fluctuations on cash and cash equivalents held | (336 | ) | 36 | |||||
| Cash and cash equivalents at end of year | 27,449 | 13,515 | ||||||
FAQ
What were the key financial results of Silence Therapeutics for the year 2020?
What clinical trials is Silence Therapeutics currently conducting?
What is the significance of the $20m payment from AstraZeneca for SLN?
What are the future plans for Silence Therapeutics' development pipeline?
How did Silence Therapeutics strengthen its leadership in 2020?
