Welcome to our dedicated page for Solid Biosciences news (Ticker: SLDB), a resource for investors and traders seeking the latest updates and insights on Solid Biosciences stock.
Solid Biosciences Inc. (Nasdaq: SLDB) is a Cambridge, MA-based biotechnology company focused on developing treatments and cures for Duchenne muscular dystrophy (DMD), a genetic muscle-wasting disease. Solid Biosciences combines commercial acumen with top-tier science to advance promising therapies that address all aspects of DMD. The core of Solid's mission is to improve the daily lives of patients and target the roots of this debilitating condition.
The company's primary focus is on developing gene therapies and other treatments for neuromuscular and cardiac diseases. Their product pipeline includes:
- SGT-003: A next-generation gene therapy candidate for DMD, recently granted FDA clearance for an Investigational New Drug (IND) application. The therapy uses a proprietary capsid (AAV-SLB101) to deliver a microdystrophin transgene to promote muscle function and durability. The planned Phase 1/2 trial aims to evaluate the safety and tolerability of SGT-003 in pediatric patients.
- SGT-501: A treatment for catecholaminergic polymorphic ventricular tachycardia (CPVT), a fatal childhood disease.
- AVB-401: For the treatment of BAG3-mediated dilated cardiomyopathy.
- AVB-202-TT: Aimed at treating Friedreich’s ataxia.
Solid Biosciences has made significant strides in obtaining regulatory milestones. Recently, SGT-003 was granted Orphan Drug Designation (ODD) and Rare Pediatric Disease Designation by the FDA, enhancing its potential marketability and support for clinical development.
The company has also been involved in strategic collaborations and financing activities. Notably, Solid entered a licensing agreement with Armatus Bio for the use of its AAV-SLB101 capsid, securing a non-exclusive worldwide license and upfront and milestone payments. In January 2024, they raised $108.9 million from a private placement to support ongoing pipeline development and business activities.
Financially, Solid Biosciences reported a net loss of $96.0 million for 2023 but expects its cash reserves and recent financing to fund strategic priorities into 2026. As of December 31, 2023, the company had $123.6 million in cash, cash equivalents, and available-for-sale securities.
For more detailed information, visit www.solidbio.com.
Solid Biosciences (Nasdaq: SLDB) announced participation in a virtual fireside chat at the Chardan 5th Annual Genetic Medicines Manufacturing Summit on April 27, 2021, at 10:30 am ET. Joel Schneider, COO, and Louise Perry, Head of Technical Operations, will discuss advancements in therapies for Duchenne muscular dystrophy.
A live webcast will be available on the Company's investor relations website, and a replay can be accessed afterwards.
Solid Biosciences (Nasdaq: SLDB) announced that Dr. Carl Morris, Chief Scientific Officer, will participate in a panel discussion on Duchenne muscular dystrophy (DMD) at the virtual Guggenheim Healthcare Talks on April 1, 2021, from 9:00 a.m. to 9:50 a.m. EDT. The panel, titled “The more we learn the less we know about DMD,” will explore advancements in DMD therapies. A live webcast of the event will be available on the company’s investor relations website, with a replay accessible afterward.
Solid Biosciences (Nasdaq: SLDB) announced the closing of an underwritten public offering of 25 million shares of common stock at $5.75 each, generating approximately $143.8 million in gross proceeds. This offering included 3.26 million shares from the underwriters' option to purchase additional shares. Jefferies, SVB Leerink, and Piper Sandler were the joint book-running managers for the offering. The shares were issued under an effective shelf registration statement, filed with the SEC on March 13, 2019, and declared effective on March 19, 2019.
Solid Biosciences (Nasdaq: SLDB) has announced the pricing of an underwritten public offering of 21,739,131 shares at $5.75 per share, generating total gross proceeds of $125 million before expenses. An option allows underwriters to purchase an additional 3,260,869 shares. The offering is expected to close on March 23, 2021, subject to customary conditions. Proceeds will fund research and development for SGT-001 and other corporate purposes. The offering involves an effective registration statement filed with the SEC.
Solid Biosciences announced a public offering of $85 million in common stock to enhance funding for its Duchenne muscular dystrophy therapies. The offering is underwritten and includes a 30-day option for underwriters to purchase an additional 15%. Jefferies, SVB Leerink, and Piper Sandler are managing the offering, which is subject to market conditions. The shares are offered under an effective registration statement filed with the SEC. No assurance can be given regarding the offering's completion or its terms due to market uncertainties.
Solid Biosciences Inc. (Nasdaq: SLDB) has reported promising interim data from its IGNITE DMD Phase I/II trial of SGT-001, a gene therapy for Duchenne muscular dystrophy. Data from six patients indicate improvements in functional endpoints, including scores from the North Star Ambulatory Assessment and the 6-Minute Walk Test, with some patients showing a mean improvement in walking distance by over 37 meters. Recent dosing of a seventh patient was successful, with manageable side effects. The next steps involve continued enrollment and evaluation of additional patient outcomes.
Solid Biosciences (Nasdaq: SLDB) announced the grant of an inducement award to its new Chief Legal Officer, Erin Brennan, as approved by independent directors on February 25, 2021. The inducement award consists of an option to purchase 325,000 shares of common stock at an exercise price of $8.52 per share, with a ten-year term and vesting in four equal annual installments. This appointment aims to strengthen the company's leadership in developing therapies for Duchenne muscular dystrophy.
Solid Biosciences (Nasdaq: SLDB) announces key leadership changes aimed at advancing therapies for Duchenne muscular dystrophy. Erin Powers Brennan joins as Chief Legal Officer, while Joel Schneider is promoted to Chief Operating Officer. The company also expands its Board of Directors with the appointments of Clare Kahn and Georgia Keresty, both experienced in the healthcare and pharmaceutical sectors. These moves are expected to enhance the company's strategic direction and operational capabilities in developing its lead gene therapy candidate, SGT-001, and improving patient outcomes.
Solid Biosciences (Nasdaq: SLDB) announced the presentation of one-year efficacy and safety data from the ongoing IGNITE-DMD Phase I/II study of SGT-001 microdystrophin gene therapy for Duchenne muscular dystrophy. Principal Investigator Dr. Barry Byrne will present the findings at the 2021 MDA Virtual Clinical & Scientific Conference on March 18 at 4 PM ET. Additionally, a symposium on Real World Outcomes Measures will take place on the same day. A conference call discussing interim data and financial results is scheduled for March 15 at 4:30 PM ET.
Solid Biosciences (Nasdaq: SLDB) has announced participation in two upcoming investor conferences. Chief Technology Officer Joel Schneider and Acting Chief Medical Officer Cathryn Clary will present at the SVB Leerink 10th Annual Global Healthcare Conference on February 24, 2021, at 1:40 p.m. ET, and at the Barclays Global Healthcare Conference on March 11, 2021, at 9:45 a.m. ET. Live webcasts will be available on the company’s investor relations website, with replays also accessible afterwards. Solid Biosciences aims to develop therapies for Duchenne muscular dystrophy through its lead gene therapy candidate, SGT-001.
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