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Sagimet Biosciences Inc. (Nasdaq: SGMT) is a clinical-stage biopharmaceutical company committed to discovering and developing novel therapeutics targeting dysfunctional metabolic pathways. The company's lead drug candidate, denifanstat, is an innovative, oral, once-daily pill that selectively inhibits fatty acid synthase (FASN). This inhibitor is specifically designed for the treatment of nonalcoholic steatohepatitis (NASH), a severe and progressive liver disease.
Denifanstat has recently achieved significant milestones. The FASCINATE-2 Phase 2b clinical trial demonstrated statistically significant improvements in primary and multiple secondary endpoints at week 52 in 168 NASH patients with stage 2 or 3 fibrosis. The results showed that denifanstat was generally well-tolerated, with the majority of adverse events being mild to moderate. Importantly, no treatment-related serious adverse events were observed.
Under an exclusive license agreement, Gannex Pharma Co., Ltd., a wholly-owned subsidiary of Ascletis Pharma Inc., holds the rights to develop, manufacture, and commercialize denifanstat (referred to as ASC40) in Greater China.
Founded in 2019, Gannex focuses on the R&D and commercialization of novel drugs for NASH, with three clinical stage candidates targeting different pathways—FASN, THRβ, and FXR. Ascletis Pharma Inc., listed on the Hong Kong Stock Exchange, leads the global effort in viral diseases, NASH, and oncology, with several advanced drug candidates in its pipeline.
Sagimet's commitment to addressing unmet medical needs in metabolic dysfunction has placed it at the forefront of NASH treatment innovation. The company's current projects and partnerships highlight its potential for significant impact in the biopharmaceutical industry.
FAQ
What is the current stock price of Sagimet Biosciences Series A (SGMT)?
The current stock price of Sagimet Biosciences Series A (SGMT) is $4.2 as of January 24, 2025.
What is the market cap of Sagimet Biosciences Series A (SGMT)?
The market cap of Sagimet Biosciences Series A (SGMT) is approximately 135.2M.
What is Sagimet Biosciences Inc.?
Sagimet Biosciences Inc. is a clinical-stage biopharmaceutical company focused on developing novel fatty acid synthase (FASN) inhibitors for treating diseases caused by dysfunctional lipid metabolism pathways.
What is denifanstat?
Denifanstat is Sagimet's lead drug candidate, an oral, once-daily pill that selectively inhibits fatty acid synthase (FASN), designed for the treatment of nonalcoholic steatohepatitis (NASH).
What were the results of the FASCINATE-2 Phase 2b clinical trial?
The FASCINATE-2 Phase 2b trial showed that denifanstat achieved significant improvements in primary and multiple secondary endpoints at week 52 in NASH patients with stage 2 or 3 fibrosis. The treatment was well-tolerated with mostly mild to moderate adverse events.
Who holds the rights to denifanstat in Greater China?
Gannex Pharma Co., Ltd., a wholly-owned subsidiary of Ascletis Pharma Inc., holds the exclusive rights to develop, manufacture, and commercialize denifanstat (ASC40) in Greater China.
What is NASH?
Nonalcoholic steatohepatitis (NASH) is a progressive and severe liver disease characterized by inflammation and damage caused by fat buildup in the liver. It is associated with an increased risk of cirrhosis and liver cancer.
How does denifanstat work?
Denifanstat works by selectively inhibiting fatty acid synthase (FASN), a key enzyme involved in lipid metabolism. This inhibition reduces fat accumulation, inflammation, and fibrosis in the liver.
What other projects is Sagimet Biosciences working on?
Sagimet is focused on developing a portfolio of selective FASN inhibitors for treating diseases resulting from dysfunctional lipid metabolism pathways. Their lead candidate, denifanstat, is in advanced clinical development for NASH.
What is the significance of the partnership with Gannex Pharma?
The partnership with Gannex Pharma allows Sagimet to leverage Gannex's expertise in R&D and commercialization in Greater China, accelerating the development and availability of denifanstat in that region.
What are the company's future plans?
Sagimet's future plans include initiating a Phase 3 registrational program for denifanstat in MASH with fibrosis, and continuing to advance their pipeline of selective FASN inhibitors.
Where can I find more information about Sagimet Biosciences?
You can learn more about Sagimet Biosciences by visiting their website at www.sagimet.com.