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Sagimet Biosciences Inc. Series A - SGMT STOCK NEWS

Welcome to our dedicated page for Sagimet Biosciences Series A news (Ticker: SGMT), a resource for investors and traders seeking the latest updates and insights on Sagimet Biosciences Series A stock.

Sagimet Biosciences Inc. (Nasdaq: SGMT) is a clinical-stage biopharmaceutical company committed to discovering and developing novel therapeutics targeting dysfunctional metabolic pathways. The company's lead drug candidate, denifanstat, is an innovative, oral, once-daily pill that selectively inhibits fatty acid synthase (FASN). This inhibitor is specifically designed for the treatment of nonalcoholic steatohepatitis (NASH), a severe and progressive liver disease.

Denifanstat has recently achieved significant milestones. The FASCINATE-2 Phase 2b clinical trial demonstrated statistically significant improvements in primary and multiple secondary endpoints at week 52 in 168 NASH patients with stage 2 or 3 fibrosis. The results showed that denifanstat was generally well-tolerated, with the majority of adverse events being mild to moderate. Importantly, no treatment-related serious adverse events were observed.

Under an exclusive license agreement, Gannex Pharma Co., Ltd., a wholly-owned subsidiary of Ascletis Pharma Inc., holds the rights to develop, manufacture, and commercialize denifanstat (referred to as ASC40) in Greater China.

Founded in 2019, Gannex focuses on the R&D and commercialization of novel drugs for NASH, with three clinical stage candidates targeting different pathways—FASN, THRβ, and FXR. Ascletis Pharma Inc., listed on the Hong Kong Stock Exchange, leads the global effort in viral diseases, NASH, and oncology, with several advanced drug candidates in its pipeline.

Sagimet's commitment to addressing unmet medical needs in metabolic dysfunction has placed it at the forefront of NASH treatment innovation. The company's current projects and partnerships highlight its potential for significant impact in the biopharmaceutical industry.

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Sagimet Biosciences Inc. (SGMT) will present preclinical data at the 7th Obesity and NASH Drug Development Summit on November 28, 2023, in Boston. The data demonstrates the effectiveness of their FASN inhibitor in reducing liver fibrosis in a preclinical mouse model of NASH, supporting further clinical evaluation. Sagimet remains focused on advancing denifanstat as a potential monotherapy and is on track to report topline results of their FASCINATE-2 Phase 2b clinical trial in the first quarter of next year.
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Sagimet Biosciences Inc. (SGMT) to participate in the 35th Annual Piper Sandler Healthcare Conference. CEO and CMO to hold fireside chat and one-on-one meetings with investors.
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Sagimet Biosciences Inc. (SGMT) reported financial results for Q3 2023, with key updates on clinical trials for denifanstat in NASH, oncology, and acne. The company anticipates topline week 52 liver biopsy results from the Phase 2b FASCINATE-2 trial in Q1 2024. Financially, Sagimet's cash and cash equivalents were $101.8 million, with revenues of $2.0 million for Q3 2023.
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Sagimet Biosciences Inc. (Nasdaq: SGMT) announced positive results from a preclinical study detailing the combination treatment of a FASN inhibitor with semaglutide for NASH, showing significant improvement in liver fibrosis. The company is on track to report Phase 2b clinical trial results, including liver biopsy, in Q1 2024.
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Sagimet Biosciences announces acceptance of two abstracts at AASLD conference
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Sagimet Biosciences to participate in fireside chat and investor meetings at NASH Investor Conference
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Sagimet Biosciences' license partner, Ascletis, has enrolled 120 patients in its Phase 3 clinical trial for denifanstat combined with bevacizumab for recurrent glioblastoma, which is expected to provide sufficient events for an interim analysis of progression-free survival.
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Sagimet Biosciences completes upsized IPO raising $96.4M in gross proceeds. Positive data from Phase 2b trial shows denifanstat well-tolerated and meeting liver fat response endpoint. Leadership changes implemented. Financial results show cash balance of $18.5M as of June 30, 2023, with net proceeds of $86.2M from IPO.
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Sagimet Biosciences Inc. has announced the closing of the sale of an additional 714,272 shares of Series A common stock at the initial public offering price of $16.00 per share. After the exercise of the underwriters' option, Sagimet has issued a total of 6,026,772 Series A common stock, raising approximately $96.4 million in gross proceeds.
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Sagimet Biosciences Inc. (Nasdaq: SGMT) announced leadership changes and appointments, welcoming Elizabeth Rozek as General Counsel & Chief Compliance Officer and Anthony M. Rimac as the new Chief Financial Officer. Dennis Hom will continue to serve in an advisory capacity, while Gordon Ringold, Ph.D., and James F. Young, Ph.D., have stepped down from the board of directors. The company aims to strengthen its ability to advance its pipeline of FASN inhibitors for areas of high unmet need, including NASH, acne, and oncology.
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FAQ

What is the current stock price of Sagimet Biosciences Series A (SGMT)?

The current stock price of Sagimet Biosciences Series A (SGMT) is $4.95 as of December 20, 2024.

What is the market cap of Sagimet Biosciences Series A (SGMT)?

The market cap of Sagimet Biosciences Series A (SGMT) is approximately 164.2M.

What is Sagimet Biosciences Inc.?

Sagimet Biosciences Inc. is a clinical-stage biopharmaceutical company focused on developing novel fatty acid synthase (FASN) inhibitors for treating diseases caused by dysfunctional lipid metabolism pathways.

What is denifanstat?

Denifanstat is Sagimet's lead drug candidate, an oral, once-daily pill that selectively inhibits fatty acid synthase (FASN), designed for the treatment of nonalcoholic steatohepatitis (NASH).

What were the results of the FASCINATE-2 Phase 2b clinical trial?

The FASCINATE-2 Phase 2b trial showed that denifanstat achieved significant improvements in primary and multiple secondary endpoints at week 52 in NASH patients with stage 2 or 3 fibrosis. The treatment was well-tolerated with mostly mild to moderate adverse events.

Who holds the rights to denifanstat in Greater China?

Gannex Pharma Co., Ltd., a wholly-owned subsidiary of Ascletis Pharma Inc., holds the exclusive rights to develop, manufacture, and commercialize denifanstat (ASC40) in Greater China.

What is NASH?

Nonalcoholic steatohepatitis (NASH) is a progressive and severe liver disease characterized by inflammation and damage caused by fat buildup in the liver. It is associated with an increased risk of cirrhosis and liver cancer.

How does denifanstat work?

Denifanstat works by selectively inhibiting fatty acid synthase (FASN), a key enzyme involved in lipid metabolism. This inhibition reduces fat accumulation, inflammation, and fibrosis in the liver.

What other projects is Sagimet Biosciences working on?

Sagimet is focused on developing a portfolio of selective FASN inhibitors for treating diseases resulting from dysfunctional lipid metabolism pathways. Their lead candidate, denifanstat, is in advanced clinical development for NASH.

What is the significance of the partnership with Gannex Pharma?

The partnership with Gannex Pharma allows Sagimet to leverage Gannex's expertise in R&D and commercialization in Greater China, accelerating the development and availability of denifanstat in that region.

What are the company's future plans?

Sagimet's future plans include initiating a Phase 3 registrational program for denifanstat in MASH with fibrosis, and continuing to advance their pipeline of selective FASN inhibitors.

Where can I find more information about Sagimet Biosciences?

You can learn more about Sagimet Biosciences by visiting their website at www.sagimet.com.

Sagimet Biosciences Inc. Series A

Nasdaq:SGMT

SGMT Rankings

SGMT Stock Data

164.20M
26.35M
14.11%
66.94%
12.96%
Biotechnology
Pharmaceutical Preparations
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United States of America
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