Sangamo Therapeutics Reports Recent Business Highlights and Fourth Quarter and Full Year 2020 Financial Results
Sangamo Therapeutics reported a consolidated net loss of $40.7 million for Q4 2020, compared to a net income of $4.5 million in Q4 2019. Revenues dropped to $25.8 million from $54.9 million year-over-year. For the full year, the company posted a net loss of $121.1 million, versus $95.4 million in 2019, although total revenues rose to $118.2 million from $102.4 million due to new collaborations. Sangamo has expanded its AAV manufacturing capabilities and entered significant collaborations with Biogen and Novartis, focusing on expanding clinical operations in 2021.
- Total revenues increased to $118.2 million in 2020, up from $102.4 million in 2019.
- Opened in-house AAV manufacturing capabilities, enhancing production capacity.
- Entered collaborations with Biogen and Novartis for gene regulation therapies.
- Q4 consolidated net loss was $40.7 million, a significant drop from a net income of $4.5 million in Q4 2019.
- Revenues for Q4 2020 fell to $25.8 million, down from $54.9 million in Q4 2019, primarily due to decreased milestones from Pfizer.
Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a genomic medicine company, today reported fourth quarter and full year 2020 financial results and recent business highlights.
“We are very pleased with our execution and the progress we made in the challenging year of 2020 during the pandemic, where we advanced our hemophilia A product candidate into a Phase 3 clinical trial with Pfizer, dosed patients in our Phase 1/2 clinical study evaluating our wholly owned product candidate treating Fabry disease, entered into transformational neuroscience collaborations with Biogen and Novartis, brought in-house AAV manufacturing online in our Brisbane headquarters, and built a strong cash position,” said Sandy Macrae, Chief Executive Officer of Sangamo. “In 2021, we will continue to build on our momentum with a focus on clinical execution and bringing our in-house cell therapy manufacturing facilities online.”
Fourth Quarter Updates and Recent Business Highlights
- Presented with collaborator Pfizer updated follow-up data from the Phase 1/2 Alta study of giroctocogene fitelparvovec, a gene therapy product candidate to treat hemophilia A, which was generally well-tolerated and demonstrated sustained Factor VIII activity levels in the therapeutic range through one year for the five patients in the highest dose cohort. The data were presented at the 62nd American Society for Hematology Annual Meeting.
- Announced with Pfizer that the first participant has been dosed in the registrational Phase 3 AFFINE trial of giroctocogene fitelparvovec.
- Completed dosing in February 2021 of the third patient in the Phase 1/2 STAAR study evaluating ST-920 gene therapy for Fabry disease. This is the first patient in the second dose cohort.
- Brought in-house AAV manufacturing capabilities online in Sangamo’s Brisbane, California headquarters at the end of 2020.
- Announced global collaboration with Novartis to develop and commercialize gene regulation therapies to treat three neurodevelopmental targets, including genes linked to autism spectrum disorder and intellectual disability.
- Announced global collaboration with Biogen to develop and commercialize gene regulation therapies for Alzheimer’s, Parkinson’s, neuromuscular and other neurological diseases.
Fourth Quarter and Full Year 2020 Financial Results
Consolidated net loss for the fourth quarter ended December 31, 2020 was
Revenues
Revenues for the fourth quarter ended December 31, 2020 were
Revenues were
Operating expenses
Three Months Ended December 31, |
|
Year Ended December 31, |
||||||||||||||
| (In millions) | 2020 |
|
2019 |
|
2020 |
|
2019 |
|||||||||
| Research and development | $ |
52.4 |
|
$ |
38.3 |
|
$ |
180.6 |
|
$ |
145.9 |
|
||||
| General and administrative |
|
16.8 |
|
|
15.1 |
|
|
67.1 |
|
|
61.7 |
|
||||
| Total operating expenses |
|
69.2 |
|
|
53.4 |
|
|
247.7 |
|
|
207.6 |
|
||||
| Stock-based compensation expense |
|
(6.6 |
) |
|
(5.2 |
) |
|
(25.7 |
) |
|
(19.3 |
) |
||||
| Non-GAAP operating expenses | $ |
62.6 |
|
$ |
48.2 |
|
$ |
222.0 |
|
$ |
188.3 |
|
||||
Total operating expenses for the fourth quarter ended December 31, 2020 were
Total operating expenses in 2020 were
The increase in operating expenses in the full year and fourth quarter was due primarily to headcount growth and facilities expansion to support the advancement of our clinical trials and manufacturing capabilities. The full year and fourth quarter increase was partially offset by a decrease in travel and corporate costs arising from the COVID-19 pandemic.
Cash, cash equivalents and marketable securities
Cash, cash equivalents and marketable securities as of December 31, 2020 were
In August 2020, we entered into an Open Market Sale Agreement with Jefferies LLC providing for the sale of up to
Initial Financial Guidance for 2021
On a GAAP basis, we expect total operating expenses in the range of approximately
We expect non-GAAP total operating expenses, excluding estimated non-cash stock-based compensation expense of approximately
Conference Call
Sangamo will host a conference call today, February 24, 2021, at 5:00 p.m. Eastern Time, which will be open to the public. The call will also be webcast with live Q&A and can be accessed via a link on the Sangamo Therapeutics website in the Investors and Media section under Events and Presentations.
The conference call dial-in numbers are (877) 377-7553 for domestic callers and (678) 894-3968 for international callers. The conference ID number for the call is 1795427. Participants may access the live webcast via a link on the Sangamo Therapeutics website in the Investors and Media section under Events and Presentations. A conference call replay will be available for one week following the conference call. The conference call replay numbers for domestic and international callers are (855) 859-2056 and (404) 537-3406, respectively. The conference ID number for the replay is 1795427.
About Sangamo Therapeutics
Sangamo Therapeutics is committed to translating ground-breaking science into genomic medicines with the potential to transform patients’ lives using gene therapy, cell therapy, and genome engineering. For more information about Sangamo, visit www.sangamo.com.
Forward-Looking Statements
This press release contains forward-looking statements regarding our current expectations. These forward-looking statements include, without limitation, statements relating to anticipated plans and timelines of Sangamo and our collaborators for conducting clinical trials and bringing in-house manufacturing facilities online, our financial resources and expectations, our 2021 financial guidance related to GAAP and non-GAAP total operating expenses and stock-based compensation and other statements that are not historical fact. These statements are not guarantees of future performance and are subject to certain risks and uncertainties that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, risks and uncertainties related to the effects of the evolving COVID-19 pandemic and the impacts of the pandemic on the global business environment, healthcare systems and business and operations of Sangamo and our collaborators, including the initiation and operation of clinical trials; the construction, opening and operation of in-house manufacturing facilities and our ability to achieve expected future financial performance.
There can be no assurance that we and our collaborators will be able to develop commercially viable products. Actual results may differ from those projected in forward-looking statements due to risks and uncertainties that exist in the operations and business environments of Sangamo and our collaborators. These risks and uncertainties are described more fully in our Securities and Exchange Commission filings and reports, including in our Annual Report on Form 10-K for the year ended December 31, 2020. Forward-looking statements contained in this announcement are made as of this date, and we undertake no duty to update such information except as required under applicable law.
Non-GAAP Financial Measure
To supplement our financial results and guidance presented in accordance with GAAP, we present non-GAAP total operating expenses, which exclude stock-based compensation expense from GAAP total operating expenses. We believe that this non-GAAP financial measure, when considered together with our financial information prepared in accordance with GAAP, can enhance investors’ and analysts’ ability to meaningfully compare our results from period to period and to our forward-looking guidance, and to identify operating trends in our business. We have excluded stock-based compensation expense because it is a non-cash expense that may vary significantly from period to period as a result of changes not directly or immediately related to the operational performance for the periods presented. This non-GAAP financial measure is in addition to, not a substitute for, or superior to, measures of financial performance prepared in accordance with GAAP. We encourage investors to carefully consider our results under GAAP, as well as our supplemental non-GAAP financial information, to more fully understand our business.
| SELECTED CONSOLIDATED FINANCIAL DATA | ||||||||||||||||
| (unaudited; in thousands, except per share data) | ||||||||||||||||
| Statement of Operations Data: | ||||||||||||||||
Three months ended |
|
Year Ended |
||||||||||||||
December 31, |
|
December 31, |
||||||||||||||
2020 |
|
2019 |
|
2020 |
|
2019 |
||||||||||
| Revenues | $ |
25,800 |
|
$ |
54,851 |
|
$ |
118,192 |
|
$ |
102,428 |
|
||||
| Operating expenses: | ||||||||||||||||
| Research and development |
|
52,358 |
|
|
38,329 |
|
|
180,647 |
|
|
145,922 |
|
||||
| General and administrative |
|
16,874 |
|
|
15,053 |
|
|
67,097 |
|
|
61,686 |
|
||||
| Total operating expenses |
|
69,232 |
|
|
53,382 |
|
|
247,744 |
|
|
207,608 |
|
||||
| (Loss) income from operations |
|
(43,432 |
) |
|
1,469 |
|
|
(129,552 |
) |
|
(105,180 |
) |
||||
| Interest and other income, net |
|
2,865 |
|
|
3,032 |
|
|
8,775 |
|
|
9,761 |
|
||||
| (Loss) income before income taxes |
|
(40,567 |
) |
|
4,501 |
|
|
(120,777 |
) |
|
(95,419 |
) |
||||
| Income tax expense |
|
108 |
|
|
- |
|
|
345 |
|
|
- |
|
||||
| Net (loss) income |
|
(40,675 |
) |
|
4,501 |
|
|
(121,122 |
) |
|
(95,419 |
) |
||||
| Net loss attributable to non-controlling interest |
|
(71 |
) |
|
(54 |
) |
|
(126 |
) |
|
(233 |
) |
||||
| Net (loss) income to Sangamo Therapeutics, Inc. stockholders | $ |
(40,604 |
) |
$ |
4,555 |
|
$ |
(120,996 |
) |
$ |
(95,186 |
) |
||||
| Basic and diluted net (loss) income per share attributable to Sangamo Therapeutics, Inc. stockholders | $ |
(0.29 |
) |
$ |
0.04 |
|
$ |
(0.90 |
) |
$ |
(0.85 |
) |
||||
| Shares used in computing basic net (loss) income per share attributable to Sangamo Therapeutics, Inc. stockholders |
|
141,508 |
|
|
115,903 |
|
|
134,449 |
|
|
112,114 |
|
||||
| Shares used in computing diluted net (loss) income per share attributable to Sangamo Therapeutics, Inc. stockholders |
|
141,508 |
|
|
126,653 |
|
|
134,449 |
|
|
112,114 |
|
||||
| Balance Sheet Data: | ||||||||||||||||
| December 31, 2020 |
December 31, 2019 |
|||||||||||||||
| Cash, cash equivalents and marketable securities | $ |
691,953 |
|
$ |
384,306 |
|
||||||||||
| Total assets |
|
938,550 |
|
|
637,516 |
|
||||||||||
| Total stockholders' equity |
|
497,366 |
|
|
432,739 |
|
||||||||||
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