Repare Therapeutics to Present Preliminary Phase 1 MYTHIC Module 1 and 2 Data at 35th AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Repare Therapeutics will present initial data from Module 1 and 2 of its Phase 1 MYTHIC clinical trial at the AACR-NCI-EORTC conference. The trial is evaluating lunresertib alone and in combination with camonsertib in solid tumors. The company will also present posters highlighting preclinical and clinical developments, including data from Module 4 of its Phase 1/2 TRESR trial.
- None.
Module 1 and 2 of the Phase 1 MYTHIC clinical trial are evaluating lunresertib (
Details for the plenary and poster presentations are as follows:
Title: MYTHIC: First-in-human (FIH) biomarker-driven phase I trial of PKMYT1 inhibitor lunresertib (lunre) alone and with ATR inhibitor camonsertib (cam) in solid tumors with CCNE1 amplification or deleterious alterations in FBXW7 or PPP2R1A
Presenter: Dr. Timothy A. Yap, The University of Texas MD Anderson Cancer Center,
Abstract number: 35396
Poster number: B156
Session: Plenary Session 4: New Drugs on the Horizon
Session date and time: Friday, October 13 | 9:40 a.m. – 11:45 a.m. ET
Session location: Level 3, Ballroom AB
Title: Ataxia telangiectasia- and Rad3-related kinase inhibitor (ATRi) camonsertib in combination with low dose gemcitabine in patients with solid tumors with DNA damage response (DDR) aberrations: Preclinical and Phase 1b results
Presenter: Dr. Ezra Rosen, Medical Oncology, Memorial Sloan Kettering Cancer Center,
Poster number: B045
Session: Poster Session B
Session date and time: Friday, October 13 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D
Title: Circulating tumor DNA (ctDNA) genomic and epigenomic profiling (GuardantINFINITY) for diagnosis of DNA damage repair (DDR) loss of function (LOF) and response monitoring in the TRESR and ATTACC trials
Presenter: Dr. Ezra Rosen, Medical Oncology, Memorial Sloan Kettering Cancer Center,
Poster number: A123
Session: Poster Session A
Session date and time: Thursday, October 12 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D
Title: Retrospective baseline biomarker analyses in a first-in-human Phase 1 trial of the PKMYT1 inhibitor lunresertib (
Presenter: Elia Aguado-Fraile, Repare Therapeutics
Poster number: B169
Session: Poster Session B
Session date and time: Friday, October 13 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D
Title: Preclinical development of PKMYT1 and ATR inhibitor combinations
Presenter: Michael Zimmerman, Repare Therapeutics
Poster number: B057
Session: Poster Session B
Session date and time: Friday, October 13 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D
Title: Preclinical development of PKMYT1 and WEE1 inhibitor combinations
Presenter: David Gallo, Repare Therapeutics
Poster number: A023
Session: Poster Session A
Session date and time: Thursday, October 12 | 12:30 p.m. – 4:00 p.m. ET
Session location: Level 2, Exhibit Hall D
About Repare Therapeutics’ SNIPRx® Platform
Repare’s SNIPRx® platform is a genome-wide CRISPR-based screening approach that utilizes proprietary isogenic cell lines to identify novel and known synthetic lethal gene pairs and the corresponding patients who are most likely to benefit from the Company’s therapies based on the genetic profile of their tumors. Repare’s platform enables the development of precision therapeutics in patients whose tumors contain one or more genomic alterations identified by SNIPRx® screening, in order to selectively target those tumors in patients most likely to achieve clinical benefit from resulting product candidates.
About Repare Therapeutics, Inc.
Repare Therapeutics is a leading clinical-stage precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes lunresertib (also known as
SNIPRx® is a registered trademark of Repare Therapeutics Inc.
View source version on businesswire.com: https://www.businesswire.com/news/home/20230919216180/en/
Repare:
Steve Forte
Executive Vice-President and Chief Financial Officer
Repare Therapeutics Inc.
investor@reparerx.com
Investors:
Matthew DeYoung
Argot Partners
repare@argotpartners.com
Media:
David Rosen
Argot Partners
david.rosen@argotpartners.com
212-600-1902
Source: Repare Therapeutics Inc.
