Repare Therapeutics to Present Comprehensive Phase 1 Monotherapy Data From the Phase 1/2 TRESR RP-3500 Clinical Trial and SNiPDx Panel at the 2022 AACR Annual Meeting

Rhea-AI Summary

Repare Therapeutics (NASDAQ: RPTX) announced that it will present clinical data from its Phase 1/2 TRESR trial of RP-3500 at the upcoming 2022 AACR Annual Meeting in New Orleans. The oral presentation, focusing on genomic determinants of response to RP-3500 in patients with DNA damage repair mutant tumors, is scheduled for April 11, 2022. Additionally, a poster will be presented on the SNiPDx panel, aimed at detecting DNA repair gene losses in tumor samples, on April 12, 2022. Repare’s SNIPRx® platform supports its precision therapeutics development.

Positive

• Oral presentation of RP-3500 trial results at the 2022 AACR Annual Meeting showcases ongoing clinical progress.
• The SNiPDx panel presentation reflects innovative approaches in synthetic lethal drug discovery.
• Repare's SNIPRx® platform could potentially enhance the efficacy of its therapeutic candidates.

Negative

• None.

CAMBRIDGE, Mass. & MONTREAL--(BUSINESS WIRE)-- Repare Therapeutics Inc. (“Repare” or the “Company”) (Nasdaq: RPTX), a leading clinical-stage precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics, today announced it has been selected for an oral presentation of clinical data from its ongoing Phase 1/2 TRESR trial of RP-3500 and a poster presentation of initial discovery and validation data of the novel Synthetic Lethal Interactions for Precision Diagnostics (SNiPDx) panel to understand allelic status of STEP2 genes at the upcoming 2022 AACR Annual Meeting, being held in New Orleans on April 8-13, 2022.

Oral Presentation Details on RP-3500 Phase 1/2 TRESR Trial Results:
Title: Genomic and pathologic determinants of response to RP-3500, an ataxia telangiectasia and Rad3-related inhibitor (ATRi), in patients (pts) with DNA damage repair (DDR) loss-of-function (LOF) mutant tumors in the Phase 1/2 TRESR trial
Presenter: Dr. Timothy Yap, MBBS, Ph.D., FRCP, Medical Director, Institute for Applied Cancer Science, Associate Professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, Texas
Abstract Number: CT030
Session Title: Clinical Trials Minisymposium - Patient Selection Strategies for Molecularly Targeted Agents in Clinical Trials
Date/ Time: Monday, Apr 11, 2022 at 2:30 PM - 4:30 PM CT

Poster Presentation Details on SNiPDx Panel for Synthetic Lethal Drug Discovery:
Title: Detection of biallelic loss of DNA repair genes in formalin-fixed, paraffin embedded (FFPE) tumor samples using a novel tumor-only sequencing panel with error correction
Presenter: Dominik Glodzik, Ph.D., Repare Therapeutics, Instructor in Biomedical Informatics, Harvard Medical School
Abstract Number: 2801
Session Title: Diagnostic Biomarkers
Date/ Time: Tuesday, April 12, 2022 at 9:00 AM CT

About Repare Therapeutics’ SNIPRx^® Platform

Repare’s SNIPRx® platform is a genome-wide CRISPR-based screening approach that utilizes proprietary isogenic cell lines to identify novel and known synthetic lethal gene pairs and the corresponding patients who are most likely to benefit from the Company’s therapies based on the genetic profile of their tumors. Repare’s platform enables the development of precision therapeutics in patients whose tumors contain one or more genomic alterations identified by SNIPRx® screening, in order to selectively target those tumors in patients most likely to achieve clinical benefit from resulting product candidates.

About Repare Therapeutics, Inc.

Repare Therapeutics is a leading clinical-stage precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx® platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s pipeline includes its lead product candidate RP-3500, a potential leading ATR inhibitor currently in Phase 1/2 clinical development, its second clinical candidate, RP-6306, a PKMYT1 inhibitor currently in Phase 1 clinical development, a Polθ inhibitor program, as well as eight other early-stage, pre-clinical programs. For more information, please visit reparerx.com.

SNIPRx^® is a registered trademark of Repare Therapeutics Inc.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220308006230/en/

Repare Contact:

Steve Forte

Chief Financial Officer

Repare Therapeutics Inc.

info@reparerx.com

Investors:

Kimberly Minarovich

Argot Partners

repare@argotpartners.com

Media:

David Rosen

Argot Partners

david.rosen@argotpartners.com

212-600-1902

Source: Repare Therapeutics Inc.

FAQ

What is the focus of the RP-3500 Phase 1/2 TRESR trial?

The RP-3500 Phase 1/2 TRESR trial focuses on genomic and pathologic determinants of response in patients with DNA damage repair mutant tumors.

When will Repare present its clinical data at the AACR Annual Meeting?

Repare will present its clinical data on April 11, 2022, during the AACR Annual Meeting in New Orleans.

What is the purpose of the SNiPDx panel being presented?

The SNiPDx panel is designed to detect biallelic loss of DNA repair genes in tumor samples, aiding in precision oncology.

What is significant about Repare Therapeutics' SNIPRx® platform?

The SNIPRx® platform allows for the identification of synthetic lethal gene pairs to develop targeted cancer therapies based on genetic profiles.