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Royalty Pharma plc (Nasdaq: RPRX) is the leading acquirer of revenue-producing intellectual property, primarily focusing on royalty interests in marketed and late-stage biopharmaceutical products. Established in 1996, the company has built a robust portfolio with over $13 billion in assets and has invested nearly $5.8 billion to date. Royalty Pharma excels in acquiring and managing diverse royalty interests across various therapeutic areas, mitigating the common risks associated with biopharmaceutical investments.
Royalty Pharma's portfolio includes royalties on more than 35 commercial products, such as AbbVie and Johnson & Johnson's Imbruvica for blood cancers, Biogen's Tysabri for multiple sclerosis, and Vertex's cystic fibrosis drugs. The company also holds interests in 14 development-stage products, demonstrating its commitment to funding innovation in the biopharmaceutical sector.
Recent achievements include a $525 million acquisition of royalties and milestones on frexalimab, a promising therapy developed by Sanofi for multiple sclerosis and other immune-mediated diseases. This transaction enhances Royalty Pharma's development-stage portfolio, reinforcing its potential for long-term growth.
Financially, Royalty Pharma reported first-quarter 2024 results reflecting strong royalty receipts growth, driven by key therapies like Trelegy and Vertex’s cystic fibrosis franchise. The company maintains a solid liquidity position with $843 million in cash and cash equivalents and a total debt of $6.3 billion.
Royalty Pharma's strategic partnerships span a broad spectrum of innovators, from academic institutions and research hospitals to leading global pharmaceutical companies. This extensive collaboration network underscores the company's pivotal role in advancing medical research and providing essential funding for late-stage clinical trials and new product launches.
For more information, visit www.royaltypharma.com.
Royalty Pharma (RPRX) has entered into an R&D funding agreement with Biogen, committing up to $250 million to support the development of litifilimab, a first-in-class investigational drug for lupus treatment. The funding will be provided over six quarters in exchange for regulatory milestones and mid-single digit royalties on worldwide sales.
Litifilimab is currently in Phase 3 trials for both systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE), with results expected between 2026 and 2027. The drug has shown proof of concept and a generally well-tolerated safety profile in both conditions, with results published in the New England Journal of Medicine. SLE affects over 3 million patients worldwide, and litifilimab could potentially become the first targeted biologic specifically approved for CLE treatment.
Royalty Pharma (RPRX) reported strong financial results for Q4 and FY 2024, with Portfolio Receipts reaching $742 million in Q4 and $2,801 million for FY 2024. The company achieved 12% growth in Royalty Receipts in Q4 and 13% for FY 2024, driven by strong performance from products including Evrysdi, CF franchise, Trelegy, and Tremfya.
Key highlights include $2.8 billion in capital deployment in 2024, with royalties acquired on eight new therapies. The company provided 2025 guidance projecting Portfolio Receipts between $2,900-$3,050 million, representing 4-9% growth. Net cash from operations was $743 million in Q4 and $2,769 million for FY 2024.
In January 2025, RPRX announced a new $3 billion share repurchase program, with plans to repurchase $2 billion in 2025. The company also announced the acquisition of its external manager, expected to generate over $100 million in cash savings by 2026.
Royalty Pharma (RPRX) has completed the monetization of MorphoSys Development Funding Bonds, receiving $511 million in upfront cash. Combined with previous payments, this brings total proceeds to $530 million on their original $300 million investment made in September 2022.
The monetization was executed at a 5.35% discount rate, following Novartis' acquisition of MorphoSys. Prior to this transaction, RPRX received two quarterly payments of $9.7 million each in Q4 2024 and January 2025. The company plans to reinvest the proceeds into share repurchases and new royalty acquisitions as part of their updated capital allocation strategy.
The Development Funding Bonds were part of a larger 2021 strategic partnership where RPRX provided up to $2.025 billion for MorphoSys' acquisition of Constellation Pharmaceuticals, including royalties on Tremfya and other development-stage assets.
Royalty Pharma (Nasdaq: RPRX) has scheduled its fourth quarter and full year 2024 financial results announcement for Tuesday, February 11, 2025, before U.S. markets open. The company will host a conference call and webcast at 8:30 a.m. Eastern Time on the same day. Investors can access the conference call details and live webcast through the company's website investor relations section. A replay of both the call and webcast will remain available on the website for a minimum of 30 days.
Royalty Pharma (RPRX) expects 2024 Portfolio Receipts of approximately $2.8 billion, reaching the upper end of guidance, driven by ~13% year-over-year growth in Royalty Receipts. The company deployed $2.8 billion in royalty transactions during 2024, including a record year for synthetic royalty deals at $925 million.
The company's development-stage pipeline, comprising over 40 projects, has the potential to generate peak royalties exceeding $1.2 billion annually. This is based on projected un-risk adjusted peak sales of over $21 billion for potential therapies in the late-stage pipeline.
In 2025, Royalty Pharma will benefit from several new product launches, including Voranigo, Yorvipath, Niktimvo, Rytelo, and Cobenfy. The company expects Adjusted EBITDA of $2,560-2,570 million and Portfolio Cash Flow of $2,450-2,455 million for full year 2024.
Royalty Pharma (RPRX) announced two major initiatives to enhance shareholder value: the acquisition of its external manager, RP Management, , and a new $3 billion share repurchase program. The internalization transaction will generate significant cash savings exceeding $100 million in 2026 and $175 million in 2030, with cumulative savings of over $1.6 billion over ten years.
The acquisition involves approximately 24.5 million shares of Royalty Pharma equity vesting over 5-9 years, $100 million in cash, and assuming $380 million of existing Manager debt. The total transaction value is approximately $1.1 billion. The company plans to repurchase $2 billion of shares in 2025, subject to market conditions.
The integration will simplify corporate structure, enhance governance, ensure management continuity, and increase economic returns on investments. Royalty Pharma maintains its commitment to mid-single digit annual dividend growth and investment grade credit rating.
Royalty Pharma (RPRX) has announced a 5% increase in its quarterly dividend for the first quarter of 2025. The company will pay a dividend of $0.22 per Class A ordinary share, up from the previous quarter's dividend. The payment is scheduled for March 10, 2025, and shareholders must be on record by the close of business on February 21, 2025 to receive the dividend.
Royalty Pharma (Nasdaq: RPRX) has announced its participation in two major healthcare investor conferences in December 2024. The company will present at the 7th Annual Evercore ISI HealthCONx Conference on December 3 at 12:55 p.m. ET, followed by Citi's 2024 Global Healthcare Conference on December 4 at 1:45 p.m. ET. Both presentations will be available via webcast on the company's investor relations website and will remain archived for at least thirty days.
Royalty Pharma (Nasdaq: RPRX) has awarded its inaugural Prize for Impact in Healthcare to Michael Milken, founder of the Milken Institute, Faster Cures, and the Prostate Cancer Foundation. The prize includes a $250,000 charitable donation to support medical research initiatives. Milken's Prostate Cancer Foundation has raised over $1 billion since 1993, supporting 2,240 research projects across 245 cancer centers in 28 countries, leading to FDA approval of six new drugs for advanced prostate cancer. The foundation's work has contributed to declining prostate cancer mortality rates over the past two decades.
Royalty Pharma (RPRX) has announced the acquisition of a synthetic royalty on U.S. sales of RYTELO from Geron for $125 million in cash upfront. RYTELO, FDA-approved in June 2024 for treating low- to intermediate-1 risk myelodysplastic syndromes with transfusion-dependent anemia, will generate tiered royalty payments ranging from 7.75% on annual net sales up to $500 million, 3.0% on sales between $500 million-$1 billion, and 1.0% on sales over $1 billion. The agreement includes provisions for royalty payment cessation based on multiple thresholds of the initial investment.
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