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TransCode Therapeutics, Inc. (NASDAQ: RNAZ) is a Boston-based clinical-stage biopharmaceutical company dedicated to combating metastatic disease through the discovery, development, and commercialization of novel microRNA (miRNA) therapeutics. The company's pioneering work centers around its proprietary TTX nanoparticle platform, designed to effectively deliver RNA-based therapies to target and treat various cancers.
The lead therapeutic candidate of TransCode Therapeutics, TTX-MC138, focuses on metastatic tumors that overexpress microRNA-10b, a well-known biomarker associated with metastasis. This candidate is currently undergoing rigorous clinical trials, with initial results indicating promising accumulation of the therapy in metastatic lesions.
The company also boasts a diverse pipeline of RNA therapeutic candidates, including TTX-siPDL1 and TTX-RIGA, aimed at overcoming the delivery challenges of RNA therapies and addressing novel genetic targets relevant to different cancer types. TransCode is actively engaged in expanding its research collaborations, as highlighted by its project combining the TTX platform with Debiopharm’s drug delivery technologies.
However, TransCode faces noteworthy financial and regulatory challenges. Recent communications reveal that the company is addressing compliance issues with Nasdaq listing requirements and the potential need for a reverse stock split to maintain its listing status. Despite these hurdles, TransCode remains committed to advancing its research and development efforts, securing strategic partnerships, and raising sufficient capital to drive its innovative pipeline forward.
TransCode’s vision extends beyond treating metastatic cancer; they aim to revolutionize cancer therapy by creating highly selective treatments that trigger the immune response against tumors while sparing healthy tissues. This approach is exemplified by their tumor-selective RIG-I agonists currently in development.
TransCode Therapeutics (NASDAQ: RNAZ) reported Q3 2022 financial results, highlighting significant advancements in its RNA oncology pipeline. The company remains on schedule to submit an exploratory IND application for a Phase 0 trial involving TTX-MC138 in advanced solid tumors. Recently granted orphan drug designation for TTX-siPDL1 for pancreatic cancer emphasizes its focus on high-need areas. Financially, cash reserves decreased to $8.8 million, while R&D expenses surged to $3 million, reflecting ongoing investment in therapeutic development. The company expects funding will last through Q1 2023.
TransCode Therapeutics (RNAZ) announced positive preclinical results for its immunotherapy candidate TTX-siPDL1 in treating pancreatic adenocarcinoma. After two weekly treatments with TTX-siPDL1 and gemcitabine, tumor volumes were significantly reduced, with 75% of treated animals surviving compared to 25% for gemcitabine alone. The study demonstrated effective PD-L1 inhibition and immune activation. CEO Michael Dudley highlighted the platform's capability to overcome challenges in RNA delivery within tumors, marking a significant opportunity for the company.
TransCode Therapeutics (Nasdaq: RNAZ) has announced its participation in the Sidoti Virtual Investor Conference on November 9-10, 2022. CEO Michael Dudley will present the company's advancements in RNA-based therapies targeting metastatic cancer, including its lead candidate TTX-MC138, which is entering first-in-human clinical trials. The presentation is scheduled for 2:30 pm ET on November 9 and will be available via webcast. TransCode aims to innovate cancer treatment through RNA therapeutics and has developed multiple candidates addressing various tumors.
TransCode Therapeutics, Inc. (Nasdaq: RNAZ) reported positive preclinical results for its lead candidate TTX-MC138 in treating pancreatic adenocarcinoma. The murine study showed a 40% complete response rate with treated mice and a successful pharmacodynamic response demonstrated by down-regulation of microRNA-10b. Further studies are underway to optimize dosing. TTX-MC138 has previously shown efficacy in breast cancer models, and the company plans to file an exploratory Investigational New Drug application for a Phase 0 clinical trial later this year.
TransCode Therapeutics (Nasdaq: RNAZ) announced the publication of a case study in Frontiers in Oncology regarding its lead therapeutic candidate, TTX-MC138. The study involved a feline patient with spontaneous metastatic breast cancer that had previously failed multiple chemotherapy rounds. TTX-MC138 demonstrated effective delivery to tumor cells via MRI and fluorescence microscopy. The patient experienced tolerable treatment and survived five months longer than expected, suggesting TTX-MC138's potential in advancing clinical trials for human metastatic cancer treatment.
BOSTON, Sept. 27, 2022 (GLOBE NEWSWIRE) -- TransCode Therapeutics (Nasdaq: RNAZ) announced its participation at the Chardan 6th Annual Genetic Medicines Conference on October 3-4, 2022. CEO Michael Dudley will present the company's RNA-based innovations aimed at enhancing cancer treatment, including the lead candidate TTX-MC138 focused on metastatic disease, set to enter clinical trials this year. The presentation is scheduled for 1:00 pm ET on October 3 and will be available for live streaming.
TransCode Therapeutics (RNAZ) announced the appointment of Frank J. Slack, PhD, a leader in small noncoding RNA research, to its advisory board. His expertise is anticipated to bolster the company’s mission as it enters clinical development phases with its lead product, TTX-MC138, aimed at treating metastatic cancers responsible for approximately 90% of cancer deaths globally. Slack's background includes pioneering studies on microRNAs, which are crucial for cancer targeting. This strategic addition aligns with upcoming first-in-human studies intended to advance TransCode's innovative RNA therapeutic approaches.
TransCode Therapeutics (NASDAQ: RNAZ) reported its Q2 2022 financial results and business advancements. The company is progressing with its therapeutic programs, aiming to submit an exploratory Investigational New Drug application for TTX-MC138. Notably, it received orphan drug designation for TTX-siPDL1 targeting pancreatic cancer. Cash reserves stood at $13.4 million as of June 30, 2022, down from $20.8 million at the end of 2021, with an operating loss of $4.7 million. A strategic alliance with MD Anderson Cancer Center was also announced to enhance RNA-targeted therapies.
TransCode Therapeutics (Nasdaq: RNAZ) announced a strategic alliance with MD Anderson Cancer Center to enhance its RNA-targeted oncology pipeline. The collaboration focuses on validating therapeutic candidates through preclinical studies, which will aid future clinical trials, including the lead candidate TTX-MC138 aimed at treating metastatic cancers. The partnership aims to leverage MD Anderson's expertise to develop innovative cancer treatment options. TransCode emphasizes its commitment to advancing RNA-based therapies for improved patient outcomes.
BOSTON, July 11, 2022 (GLOBE NEWSWIRE) -- TransCode Therapeutics (NASDAQ: RNAZ) announced the filing of a provisional patent application (US 63/356,449) for a method combining radiotherapy with RNA-based nanoparticles for cancer therapy. The approach aims to activate the immune system by leveraging tumor-derived neoantigens and activating the RIG-I signaling pathway. CEO Michael Dudley emphasized the potential for enhanced cancer treatment through this technology. TransCode is advancing its lead candidate, TTX-MC138, into clinical studies, underscoring its commitment to innovative cancer solutions.