Cartesian Therapeutics Announces Positive Updated Results from Phase 2b Trial of Descartes-08 in Participants with Myasthenia Gravis and Outlines Design of Planned Phase 3 Trial
Cartesian Therapeutics (NASDAQ: RNAC) announced positive updated results from its Phase 2b trial of Descartes-08 for myasthenia gravis treatment. The trial showed deepening responses over time, with participants experiencing a 5.5-point reduction in MG-ADL at Month 4, and durable responses through Month 12. The company outlined its planned Phase 3 AURORA trial, set to commence in 1H2025, which will evaluate approximately 100 participants. The Phase 2b trial demonstrated a favorable safety profile supporting outpatient administration without preconditioning chemotherapy. Notably, participants without prior biologic therapy exposure showed particularly strong responses, with a 6.6-point average MG-ADL reduction at Month 4.
Cartesian Therapeutics (NASDAQ: RNAC) ha annunciato risultati aggiornati positivi dal suo trial di Fase 2b di Descartes-08 per il trattamento della miastenia grave. Lo studio ha mostrato risposte sempre più profonde nel tempo, con i partecipanti che hanno registrato una riduzione di 5,5 punti nel MG-ADL al mese 4 e risposte durature fino al mese 12. L'azienda ha delineato il suo trial di Fase 3 AURORA, previsto per iniziare nella prima metà del 2025, che valuterà circa 100 partecipanti. Il trial di Fase 2b ha dimostrato un profilo di sicurezza favorevole che supporta la somministrazione ambulatoriale senza precondizionamento chemioterapico. È notevole che i partecipanti senza esposizione precedente a terapie biologiche abbiano mostrato risposte particolarmente forti, con una riduzione media di 6,6 punti nel MG-ADL al mese 4.
Cartesian Therapeutics (NASDAQ: RNAC) anunció resultados actualizados positivos de su ensayo de Fase 2b de Descartes-08 para el tratamiento de la miastenia gravis. El ensayo mostró respuestas cada vez más profundas con el tiempo, con participantes que experimentaron una reducción de 5.5 puntos en el MG-ADL al mes 4, y respuestas duraderas hasta el mes 12. La compañía delineó su ensayo de Fase 3 AURORA, que comenzará en la primera mitad de 2025, que evaluará aproximadamente a 100 participantes. El ensayo de Fase 2b demostró un perfil de seguridad favorable que respalda la administración ambulatoria sin quimioterapia de preacondicionamiento. Es notable que los participantes sin exposición previa a terapia biológica mostraron respuestas particularmente fuertes, con una reducción promedio de 6.6 puntos en el MG-ADL al mes 4.
Cartesian Therapeutics (NASDAQ: RNAC)는 Descartes-08의 중증 근무력증 치료를 위한 2b상 시험에서 긍정적인 업데이트 결과를 발표했습니다. 이 시험은 시간이 지남에 따라 점점 더 깊어진 반응을 보였으며, 참가자들은 4개월째에 MG-ADL에서 5.5점 감소를 경험했고, 12개월까지 지속적인 반응을 나타냈습니다. 이 회사는 2025년 상반기에 시작될 예정인 3상 AURORA 시험을 계획 중이며, 약 100명의 참가자를 평가할 예정입니다. 2b상 시험은 사전 화학요법 없이 외래환자로서의 투여를 지원하는 긍정적인 안전성 프로필을 보여주었습니다. 특히, 이전에 생물학적 치료를 받은 적이 없는 참가자들은 4개월째에 평균 6.6점 감소를 보이며 특히 강한 반응을 보였습니다.
Cartesian Therapeutics (NASDAQ: RNAC) a annoncé des résultats positifs actualisés de son essai de Phase 2b de Descartes-08 pour le traitement de la myasthénie grave. L'essai a montré des réponses de plus en plus marquées au fil du temps, avec des participants enregistrant une réduction de 5,5 points dans le MG-ADL au mois 4, et des réponses durables jusqu'au mois 12. L'entreprise a présenté son essai de Phase 3 AURORA, prévu pour commencer dans la première moitié de 2025, qui évaluera environ 100 participants. L'essai de Phase 2b, a démontré un profil de sécurité favorable soutenant l'administration en ambulatoire sans chimiothérapie de préconditionnement. Il est notable que les participants sans exposition préalable à une thérapie biologique aient montré des réponses particulièrement fortes, avec une réduction moyenne de 6,6 points dans le MG-ADL au mois 4.
Cartesian Therapeutics (NASDAQ: RNAC) gab aktualisierte positive Ergebnisse aus ihrer Phase-2b-Studie zu Descartes-08 zur Behandlung von Myasthenia Gravis bekannt. Die Studie zeigte im Laufe der Zeit sich vertiefende Reaktionen, wobei die Teilnehmer eine Verringerung um 5,5 Punkte im MG-ADL nach 4 Monaten erlebten und bis Monat 12 anhaltende Reaktionen zeigten. Das Unternehmen skizzierte seine geplante Phase-3 AURORA-Studie, die im ersten Halbjahr 2025 beginnen soll und etwa 100 Teilnehmer bewerten wird. Die Phase-2b-Studie zeigte ein günstiges Sicherheitsprofil, das die ambulante Verabreichung ohne präventive Chemotherapie unterstützt. Besonders bemerkenswert ist, dass Teilnehmer ohne vorherige Exposition gegenüber biologischen Therapien besonders starke Reaktionen zeigten, mit einer durchschnittlichen Reduktion von 6,6 Punkten im MG-ADL nach 4 Monaten.
- Phase 2b trial met its primary endpoint with significant MG-ADL score improvements
- Strong efficacy with 5.5-point reduction in MG-ADL at Month 4
- 80% of evaluable participants maintained clinically meaningful response through Month 12
- Favorable safety profile with no cases of CRS or ICANS
- FDA granted RMAT and Orphan Drug Designations
- Two participants were lost to follow-up after Month 3 assessments
- long-term data with only five participants evaluable at Month 12
Insights
The Phase 2b trial results for Descartes-08 demonstrate compelling efficacy in treating myasthenia gravis (MG). Key highlights include a significant 5.5-point reduction in MG-ADL at Month 4, with even stronger results (6.6-point reduction) in biologic-naive patients. The durability of response is particularly noteworthy, with 80% of evaluable patients maintaining clinically meaningful responses through Month 12.
The safety profile is exceptional - no cases of cytokine release syndrome or neurotoxicity syndrome were reported, a significant advantage over traditional CAR-T therapies. The planned Phase 3 AURORA trial design, targeting 100 participants with a clear primary endpoint of ≥3-point MG-ADL improvement, appears well-positioned for success based on current data.
This development significantly strengthens Cartesian's market position in the MG treatment landscape. The outpatient administration without preconditioning chemotherapy represents a major commercial advantage, potentially reducing healthcare costs and improving patient accessibility. The RMAT and Orphan Drug designations provide accelerated regulatory pathways and market exclusivity benefits.
The retreatment data showing sustained efficacy suggests potential recurring revenue opportunities. With current MG treatments showing efficacy and broad immunosuppression, Descartes-08's targeted approach and strong efficacy profile could capture significant market share in this $3+ billion market.
Phase 3 AURORA trial on track to commence in 1H2025; Primary endpoint to assess proportion of Descartes-08-treated participants with myasthenia gravis demonstrating an MG-ADL improvement of ≥3 points at Month 4 relative to placebo
Deepening responses observed over time in Phase 2b trial, with Descartes-08-treated participants observed to have a 5.5-point reduction in MG-ADL at Month 4
Durable responses observed through Month 12 in Phase 2b trial
Safety profile consistent with previously reported data and continues to support outpatient administration
Company to host conference call and webcast with key opinion leader today at 7:30 a.m. ET
FREDERICK, Md., Dec. 03, 2024 (GLOBE NEWSWIRE) -- Cartesian Therapeutics, Inc. (NASDAQ: RNAC) (the “Company”), a clinical-stage biotechnology company pioneering mRNA cell therapy for autoimmune diseases, today announced updated efficacy and safety data from the Phase 2b trial of Descartes-08 in participants with generalized myasthenia gravis (MG) and provided details on the design of its planned Phase 3 AURORA trial. The updated data will be presented today at the 2nd Annual Cell Therapy for Autoimmune Disease Summit being held in Philadelphia.
Descartes-08, Cartesian’s lead mRNA cell therapy candidate, is an autologous mRNA-engineered chimeric antigen receptor T-cell therapy (mRNA CAR-T) product candidate targeting B-cell maturation antigen (BCMA). Descartes-08 is designed to be administered without preconditioning chemotherapy and does not use integrating vectors. Descartes-08 was previously granted Regenerative Medicine Advanced Therapy (RMAT) Designation and Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for the treatment of MG.
“Current standards of care are associated with broad immunosuppression and limited efficacy, and patients with MG, which is a rare and incurable autoimmune disorder, are in dire need of new treatment options,” said James F. Howard Jr., M.D., Professor of Neurology, Medicine, and Allied Health at the University of North Carolina School of Medicine, and investigator in the Phase 2b trial. “These updated results continue to show deep responses durable for months after cessation of treatment in both heavily pre-treated participants and, notably, participants without prior exposure to biologic drugs, underscoring the potential for Descartes-08 to emerge as a meaningful addition to available MG treatments.”
“Data reported today add to the growing body of evidence supporting the potential for Descartes-08 to provide deep and durable improvements for participants with MG in the convenient outpatient setting and without the need for preconditioning chemotherapy,” said Carsten Brunn, Ph.D., President and Chief Executive Officer of Cartesian. “Importantly, we believe these updated results align well with the endpoints of our planned Phase 3 trial, strengthening our confidence in the design of the next phase of Descartes-08’s development. We look forward to commencing the trial during the first half of next year as we continue to work toward our mission to deliver this much-needed therapy to patients with MG.”
Overview of Planned Phase 3 AURORA Trial
The Company today provided details on the design of its planned Phase 3 trial of Descartes-08 in patients with MG.
The randomized, double-blind, placebo-controlled Phase 3 AURORA trial is designed to assess Descartes-08 versus placebo (1:1 randomization) administered as six weekly outpatient infusions without preconditioning chemotherapy in approximately 100 participants with acetylcholine receptor autoantibody positive (AChR Ab+) MG. The primary endpoint will assess the proportion of Descartes-08 participants with an improvement in MG Activities of Daily Living (MG-ADL) score of three points or more at Month 4 compared to placebo. Secondary endpoints will assess safety and tolerability and the proportion of participants with a reduction of four points or more in MG Composite (MGC) score, as well as improvements in other validated MG severity scales, including Quantitative MG (QMG) and MG Quality of Life Revised Scale (MG-QoL-15R).
Cartesian expects to commence the trial in the first half of 2025.
Updated Phase 2b Trial Results
In the Phase 2b double-blind, placebo-controlled, crossover trial, a total of 36 heavily pre-treated, highly symptomatic participants with MG were randomized 1:1 to receive either Descartes-08 or placebo administered as six weekly outpatient infusions without preconditioning chemotherapy. As previously announced, the trial met its primary endpoint and demonstrated a safety profile supporting outpatient administration of Descartes-08.
The primary efficacy dataset for the follow-up portion of the trial consisted of a modified intent-to-treat (mITT) population of all subjects enrolled at academic medical centers who received at least one dose of Descartes-08 and completed at least one post-Month 3 MG-ADL score follow-up assessment. As of an October 31, 2024 cutoff date, 12 participants in the primary efficacy dataset completed their Month 4 and Month 6 follow-up assessments, with eight participants evaluable for their Month 9 assessment, and five participants evaluable for their Month 12 assessment. Two participants who were MGC responders at Month 3 were lost to follow-up after their Month 3 assessments and were not assessed in the follow-up portion of the treatment.
Updated Efficacy Results
- Deepening responses were observed over time, with participants included in the primary efficacy dataset (n=12) experiencing an average MG-ADL reduction of 5.5 (±1.1) at Month 4.
- At Month 4, particularly deep responses were observed in participants without prior exposure to biologic therapies (n=7), including complement or neonatal fragment crystallizable receptor (FcRn) inhibitors, with an average MG-ADL reduction of 6.6 (±1.5).
- Responses were observed to further deepen at Month 6, with
33% (4/12) of participants in the primary efficacy dataset and57% (4/7) of participants with no prior exposure to biologic therapy observed to have minimum symptom expression, defined as an MG-ADL score of 0 or 1. - Responses were observed to be durable through Month 12, with
80% (4/5) of evaluable participants from the primary efficacy dataset maintaining a clinically meaningful response, defined as a reduction in MG-ADL score of at least 2 points. - Of the two participants with no prior exposure to biologic therapy that reached Month 12, both maintained at least a clinically meaningful response, with one continuing to demonstrate minimum symptom expression.
Safety
- Descartes-08 continues to be observed as well-tolerated, supporting outpatient administration without the need for lymphodepleting chemotherapy. Consistent with previously reported data, Descartes-08 was observed to be well-tolerated across the safety dataset (n=36), and adverse events were transient and mostly mild. Notably, there were no cases of cytokine release syndrome (CRS), and no cases of immune effector cell-associated neurotoxicity syndrome (ICANS). In addition, treatment with Descartes-08 was not observed to lead to a decrease in vaccine titers for common viruses and was not associated with increased rates of infection or hypogammaglobulinemia.
Updated Phase 2a Open-Label Trial Results
Cartesian today also announced positive updated results from retreated participants enrolled in the Phase 2a open-label portion of the trial. Two participants were previously retreated, and experienced rapid improvement in clinical scores and maintained minimum symptom expression for up to one year after receiving a second treatment cycle. A third participant received a second treatment cycle and at the participant’s Month 2 visit, two weeks after the last Descartes-08 infusion, achieved a 4-point reduction in MG-ADL and 6-point reduction in MGC scores from baseline, without reports of CRS or ICANS. The time course and magnitude of treatment response upon retreatment were similar to the time course and magnitude of treatment response observed when the participants were first treated. Four of the seven remaining participants from the Phase 2a portion of the trial maintained clinically meaningful responses for at least one year following initial dosing.
The Company previously announced positive long-term follow up data from the Phase 2a trial in which Descartes-08 was administered in an outpatient setting without preconditioning chemotherapy. Durable depletion of autoantibodies and clinically meaningful improvements in MG severity scores were observed at the one-year follow-up period. The data were subsequently featured during an oral session at the American Society of Gene and Cell Therapy 27th Annual Meeting in May 2024.
Conference Call and Webcast
The Company will host a conference call and webcast to discuss the updated data, as well as the design of its planned Phase 3 trial today, Tuesday, December 3, 2024, at 7:30 a.m. ET. Joining members of the Cartesian management team will be Dr. Howard.
To access the conference call, please dial 1-800-715-9871 (toll-free) or 1-646-307-1963 (international) at least 10 minutes prior to the start time and ask to be joined into the Cartesian Therapeutics call. The live audio webcast, along with accompanying slides, can be accessed on the Events & Presentations section of Cartesian’s website at https://ir.cartesiantherapeutics.com/news-and-events/events-presentations. A replay of the webcast will be available for a limited time following the event on Cartesian’s website.
About Myasthenia Gravis
Myasthenia gravis (MG) is a chronic autoimmune disorder that causes disabling muscle weakness and fatigue. For most people with MG, the disease is characterized by the presence of antibodies against the acetylcholine receptor, a protein found on the surface of nerve cells that plays a key role in muscle contraction. There is currently no cure for MG, and treatment typically requires chronic immunosuppressive medicines, with their attendant risks and side effects.
About Descartes-08
Descartes-08, Cartesian’s lead mRNA cell therapy candidate, is an autologous mRNA-engineered chimeric antigen receptor T-cell therapy (mRNA CAR-T) product targeting B-cell maturation antigen (BCMA) in clinical development for generalized myasthenia gravis (MG) and systemic lupus erythematosus. In contrast to conventional DNA-based CAR T-cell therapies, mRNA CAR-T administration is designed to not require preconditioning chemotherapy, can be administered in the outpatient setting, and does not carry the risk of genomic integration associated with cancerous transformation. Descartes-08 has been granted Orphan Drug Designation and Regenerative Medicine Advanced Therapy Designation by the U.S. Food and Drug Administration for the treatment of MG, and Rare Pediatric Disease Designation for the treatment of juvenile dermatomyositis.
About Cartesian Therapeutics
Cartesian Therapeutics is a clinical-stage company pioneering mRNA cell therapies for the treatment of autoimmune diseases. The Company’s lead asset, Descartes-08, is an mRNA CAR-T in Phase 2b clinical development for patients with generalized myasthenia gravis and Phase 2 development for systemic lupus erythematosus, with a Phase 2 basket trial planned in additional autoimmune indications. The Company’s clinical-stage pipeline also includes Descartes-15, a next-generation, autologous anti-BCMA mRNA CAR-T. For more information, please visit www.cartesiantherapeutics.com or follow the Company on LinkedIn or X, formerly known as Twitter.
Forward Looking Statements
Any statements in this press release about the future expectations, plans and prospects of the Company, including without limitation, statements regarding observations and data from the myasthenia gravis Phase 2a/2b trial, the ability of the Company’s product candidates to be administered in an outpatient setting or without the need for preconditioning lymphodepleting chemotherapy, the potential of Descartes-08, Descartes-15, or any of the Company’s other product candidates to treat myasthenia gravis, systemic lupus erythematosus, juvenile dermatomyositis, or any other disease, the anticipated timing or the outcome of ongoing and planned clinical trials, studies and data readouts, the anticipated timing or the outcome of the FDA’s review of the Company’s regulatory filings, the Company’s ability to conduct its clinical trials and preclinical studies, the timing or making of any regulatory filings, the novelty of treatment paradigms that the Company is able to develop, the potential of any therapies developed by the Company to fulfill unmet medical needs, and enrollment in the Company’s clinical trials and other statements containing the words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “hypothesize,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including, but not limited to, the following: the uncertainties inherent in the initiation, completion and cost of clinical trials including proof of concept trials, including uncertain outcomes, the availability and timing of data from ongoing and future clinical trials and the results of such trials, whether preliminary results from a particular clinical trial will be predictive of the final results of that trial and whether results of early clinical trials will be indicative of the results of later clinical trials, the ability to predict results of studies performed on human beings based on results of studies performed on non-human subjects, the unproven approach of the Company’s technology, potential delays in enrollment of patients, undesirable side effects of the Company’s product candidates, its reliance on third parties to conduct its clinical trials, the Company’s inability to maintain its existing or future collaborations, licenses or contractual relationships, its inability to protect its proprietary technology and intellectual property, potential delays in regulatory approvals, the availability of funding sufficient for its foreseeable and unforeseeable operating expenses and capital expenditure requirements, the Company’s recurring losses from operations and negative cash flows, substantial fluctuation in the price of the Company’s common stock, risks related to geopolitical conflicts and pandemics and other important factors discussed in the “Risk Factors” section of the Company’s most recent Annual Report on Form 10-K and subsequently filed Quarterly Reports on Form 10-Q, and in other filings that the Company makes with the Securities and Exchange Commission. In addition, any forward-looking statements included in this press release represent the Company’s views only as of the date of its publication and should not be relied upon as representing its views as of any subsequent date. The Company specifically disclaims any intention to update any forward-looking statements included in this press release, except as required by law.
Investor Contact
Blaine Davis
Chief Financial Officer
blaine@cartesiantx.com
Media Contact
David Rosen
Argot Partners
david.rosen@argotpartners.com
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