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RELIEF THERAPEUTICS Holding SA, traded as RLFTF, is a biopharmaceutical company dedicated to providing innovative treatment options for select specialty, unmet, and rare diseases. The company focuses on advancing treatment paradigms and delivering improvements in efficacy, safety, and convenience to benefit patients. Relief Therapeutics offers a diversified portfolio of marketed products, proprietary platform technologies, and a targeted clinical development pipeline. With a mission to provide therapeutic relief to those suffering from rare diseases, Relief Therapeutics is led by an experienced team of industry leaders. Headquartered in Geneva, the company is listed on the SIX Swiss Exchange and quoted on the OTCQB.
Relief Therapeutics Holding SA has announced an increase in its share capital from 4.62 billion to 5.62 billion shares by issuing 1 billion new shares, fully subscribed by its subsidiary, Relief Therapeutics International SA. These new shares will be listed on the SIX Swiss Exchange around December 22, 2022. Following this issuance, Relief expects about 1.2 billion shares to be held in treasury for future financing transactions, while the outstanding shares will remain unchanged until placement.
Relief Therapeutics announces leadership changes with Jack Weinstein appointed as CEO and Jeremy Meinen as CFO. Effective immediately, Weinstein aims to enhance the company's long-term strategy following the launch of their first product, PKU GOLIKE. Meinen, who has been with Relief since 2020, now takes on more responsibility in driving financial growth. These appointments come after the settlement of litigation with NRx Pharmaceuticals, signaling a strategic shift for Relief to focus on expanding its operations in the biopharmaceutical sector.
Relief Therapeutics announced the filing of Amendment No. 1 to its Registration Statement on Form F-1 with the U.S. SEC for a proposed offering of ordinary shares in the form of American Depositary Shares (ADSs). Details regarding the number and pricing of the ADSs are yet to be determined. The company plans to list these ADSs on the NASDAQ under the symbol RLFT. The offering will only proceed with an effective prospectus.
Relief Therapeutics Holding SA and NRx Pharmaceuticals have reached settlement agreements to resolve litigation. Within the next 30 days, NRx will transfer assets used in aviptadil development to Relief. Relief will gain exclusive rights to develop and commercialize aviptadil while continuing the Right to Try Program for two years. They will pay NRx milestone payments for successful product approvals and royalties up to $30 million based on sales. NRx will refrain from future competition in aviptadil development. The success of aviptadil commercialization is uncertain.
Relief Therapeutics Holding SA and NRx Pharmaceuticals, Inc. have extended the stay of their pending litigation until November 11, 2022. They are progressing in negotiations for a settlement; however, no final agreements have been reached, introducing uncertainty about the outcome.
Relief specializes in developing treatments for rare diseases, with products including PKU GOLIKE and ongoing projects like aviptadil and APR-TD011, which has FDA Orphan Drug Designation. The company is listed on the SIX Swiss Exchange under symbol RLF and OTCQB under RLFTF and RLFTD.
Relief Therapeutics, a Swiss biopharmaceutical company, has announced promising six-month stability data for a new formulation of RLF-100 (aviptadil) that shows high purity across various temperatures. This data supports the commercialization of RLF-100, which targets serious lung diseases like pulmonary sarcoidosis and ARDS. Relief plans to initiate a Phase 2b study in 2023 for pulmonary sarcoidosis. The company has also filed a provisional patent application for this formulation, underlining its potential clinical and commercial value.
Relief Therapeutics Holding SA (SIX:RLF, OTCQB:RLFTF, RLFTY) has announced an extension of its pending litigation settlement with NRx Pharmaceuticals, Inc. until November 7, 2022. This extension provides both parties additional time to finalize their tentative settlement agreement, although there are no guarantees of a successful conclusion. Relief is a biopharmaceutical company focused on developing treatments for rare diseases and has a diverse pipeline, including therapies for metabolic disorders and pulmonary indications.
Relief Therapeutics has filed Amendment No. 2 to its Form F-6 Registration Statement with the U.S. SEC to implement a reverse split of its American Depositary Receipts (ADRs), changing the ratio from 1:150 to 1:200. This change will take effect on November 3, 2022, as part of Relief's strategy to uplist its ADRs to the NASDAQ. The new ratio means that three new ADRs will be issued for every four existing ADRs. Relief aims to enhance accessibility for U.S. investors and maintain rights comparable to holders of ordinary shares.
Relief Therapeutics announced the promotion of Paolo Galfetti to Chief Operating Officer, effective October 14, 2022. Galfetti will maintain his role as CEO of APR Applied Pharma Research and continue his contributions to Relief's Board of Directors. With extensive experience in the pharmaceutical sector and a pivotal role in Relief's management since APR's acquisition, Galfetti is expected to enhance the company’s strategic initiatives, particularly the U.S. launch of PKU GOLIKE. Relief focuses on developing treatments for rare diseases, with significant ongoing projects including ACER-001 and aviptadil.
Relief Therapeutics has launched PKU GOLIKE in the U.S., a medical food for managing phenylketonuria (PKU). This launch, aided by an exclusive distributor, fulfills a milestone from the acquisition of APR Applied Pharma Research. Relief will make a milestone payment of CHF 2.8 million and issue 150 million shares, increasing its treasury by 200 million shares. Approximately 20,000 PKU patients in the U.S. require this dietary supplement for metabolic management. PKU GOLIKE offers improved patient compliance with its unique formulation, previously available in the E.U. since 2019.