Welcome to our dedicated page for Rigel Pharmaceuticals (New) news (Ticker: RIGL), a resource for investors and traders seeking the latest updates and insights on Rigel Pharmaceuticals (New) stock.
Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) is a leading biotechnology company based in South San Francisco, California, dedicated to discovering, developing, and providing novel therapies that significantly improve the lives of patients with immune and hematologic disorders, cancer, and rare diseases. Established in 1996, Rigel has built a solid reputation in the pharmaceutical industry by focusing on the development of small-molecule drugs.
The company's flagship product, TAVALISSE (fostamatinib disodium hexahydrate) tablets, is the only oral spleen tyrosine kinase (SYK) inhibitor approved for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment.
REZLIDHIA (olutasidenib), another key product, is an oral small-molecule inhibitor of mutant isocitrate dehydrogenase-1 (mIDH1), indicated for the treatment of adult patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) with a susceptible IDH1 mutation.
Rigel's pipeline includes a variety of promising candidates such as R289, an IRAK1/4 dual inhibitor for the treatment of lower-risk myelodysplastic syndrome (LR-MDS), R552, R835, THF-beta Inhibitors, and AZD0449 - an inhaled JAK inhibitor. The company is also exploring the potential of olutasidenib in high-grade glioma (HGG) through a collaboration with CONNECT, an international network of pediatric cancer centers.
Recent financial highlights include a reported net product sales of $104.3 million in 2023, showcasing a significant growth of 36% over the previous year. Rigel's partnership with major pharmaceutical companies like AstraZeneca for their rheumatoid arthritis drug and Grifols S.A. for delivery of drug supplies reinforces their strong market position.
In 2024, Rigel announced the acquisition of U.S. rights to GAVRETO (pralsetinib), a kinase inhibitor approved for treating metastatic RET fusion-positive non-small cell lung cancer (NSCLC) and advanced or metastatic RET fusion-positive thyroid cancer. This acquisition aligns with Rigel's strategy to expand its hematology and oncology portfolio, leveraging its existing commercial infrastructure.
Rigel continues to focus on commercial execution, strategic collaborations, and advancing its robust pipeline to reach financial breakeven and deliver transformative treatments to underserved patient populations.
Optime Care has announced an enhanced partnership with Rigel Pharmaceuticals, effective July 1, 2024, to support patients using GAVRETO® (pralsetinib), a targeted cancer therapy. This collaboration leverages Optime Care’s comprehensive services, which include pre-commercialization expertise, market access, national medication fulfillment, and high-touch patient support designed to improve outcomes. The partnership aims to streamline patient access to GAVRETO® through personalized clinical guidance, support with insurance coverage, financial assistance programs, and more. Rigel Pharmaceuticals values Optime Care’s extensive experience in managing complex diseases and their commitment to patient care, aiming to improve therapeutic outcomes for patients with cancers caused by abnormal RET genes.
Rigel Pharmaceuticals announced a 1-for-10 reverse stock split, effective June 27, 2024. This decision will reduce the total outstanding shares from approximately 175.6 million to 17.6 million, aiming to increase the per-share trading price. The reverse split was approved by stockholders on May 24, 2024, and finalized by the Board on June 15, 2024. Post-split, Rigel’s stock will trade under the same symbol (RIGL) and a new CUSIP number (766559702). The reverse split intends to enhance the company’s appeal to institutional investors and maintain Nasdaq listing compliance. No action is required from stockholders who hold shares electronically or in street name; those with physical certificates will receive instructions for the exchange. Fractional shares will be compensated with cash.
Rigel Pharmaceuticals completed the transfer of the New Drug Application (NDA) for GAVRETO® (pralsetinib), an oral targeted therapy for patients with RET fusion-positive non-small cell lung cancer (NSCLC) and advanced thyroid cancer. GAVRETO will be available in the U.S. starting June 27, 2024. The NSCLC indication is fully approved by the FDA, while the advanced thyroid indication is approved under accelerated approval. The drug will be available in 100 mg capsules priced at $11,144.58 for 60 capsules and $16,716.85 for 90 capsules. Rigel offers patient assistance programs and comprehensive support through its RIGEL ONECARE® service. The acquisition of GAVRETO’s U.S. rights from Blueprint Medicines was announced in February 2024.
Rigel Pharmaceuticals (NASDAQ: RIGL) announced multiple presentations at the EHA2024 Hybrid Congress, focusing on the efficacy of REZLIDHIA® (olutasidenib) in treating mIDH1 AML. Highlights include five-year data from a Phase 2 trial indicating significant responses in heavily pretreated patients, including those resistant to prior venetoclax regimens. REZLIDHIA showed a median overall survival of 11.6 months and a 48% overall response rate. Poster presentations demonstrated olutasidenib's effectiveness across various patient subgroups, including elderly patients and those with AML secondary to MPNs. The data support REZLIDHIA as a promising treatment for mIDH1 AML with rapid, durable responses and manageable safety profiles.
Rigel Pharmaceuticals presented three studies at the 2024 ASCO Annual Meeting highlighting the long-term efficacy of REZLIDHIA® (olutasidenib) in treating relapsed or refractory (R/R) mutated isocitrate dehydrogenase-1 (mIDH1) acute myeloid leukemia (AML). The Phase 2 trial showed a 35% complete remission or partial hematologic recovery rate among 147 patients, while elderly patients (aged 75+) achieved a 31% CR/CRh rate. Additionally, Rigel presented the Phase 1b trial of R289, an IRAK1/4 inhibitor, in lower-risk myelodysplastic syndrome (LR-MDS). The studies suggest durable responses and tolerability of olutasidenib, even in difficult-to-treat cases.
Rigel Pharmaceuticals (Nasdaq: RIGL) announced that its president and CEO, Raul Rodriguez, will present a company overview at the Jefferies Global Healthcare Conference on June 6, 2024, at 9:30 am ET in New York, NY.
The presentation will be available via live webcast on Rigel's Investor Relations website.
Founded in 1996 and based in South San Francisco, Rigel focuses on developing therapies for hematologic disorders and cancer. For more information, visit www.rigel.com.
Rigel Pharmaceuticals announces significant presentations at the upcoming 2024 ASCO and EHA Hybrid Congresses, showcasing the efficacy of their lead products, REZLIDHIA (olutasidenib) for mIDH1 AML and TAVALISSE (fostamatinib) for chronic immune thrombocytopenia (ITP).
The final five-year results from the Phase 2 trial highlight REZLIDHIA's durable responses in heavily pretreated mIDH1 AML patients. Further, REZLIDHIA proves effective in elderly, transplant-eligible, and post-MPN patients.
Additionally, data from a Phase 1b trial of R2891, an IRAK1/4 inhibitor for lower-risk myelodysplastic syndrome (LR-MDS), and real-world analyses of TAVALISSE for ITP will be presented.
These results underscore Rigel's robust hematology and oncology portfolio, promising significant benefits for patients with challenging conditions.
Rigel Pharmaceuticals, Inc. reported total revenue of $29.5 million for the first quarter of 2024, driven by strong commercial demand for TAVALISSE® and REZLIDHIA®. The company acquired GAVRETO®, a U.S. marketed product for lung and thyroid cancer, expanded its portfolio, and appointed a new Chief Medical Officer. Rigel is progressing clinical trials, collaborating with MD Anderson and CONNECT, and advancing pipeline programs. Financially, total revenue included $21.1 million from TAVALISSE sales, $4.9 million from REZLIDHIA sales, and $3.5 million from collaborations. The net loss was $8.2 million. Rigel had $49.6 million in cash and investments as of March 31, 2024.
Rigel Pharmaceuticals, Inc. will report its first quarter 2024 financial results on May 7, 2024, followed by a conference call and webcast discussing financial results and business updates. Rigel Pharmaceuticals is focused on developing therapies for hematologic disorders and cancer.
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