Welcome to our dedicated page for Replimune Group news (Ticker: REPL), a resource for investors and traders seeking the latest updates and insights on Replimune Group stock.
Replimune Group, Inc. (NASDAQ: REPL) is a clinical-stage biotechnology company committed to advancing cancer treatment through innovative oncolytic immune-gene therapies. Founded in 2015 and headquartered in Woburn, Massachusetts, Replimune leverages its proprietary Immulytic™ platform to develop product candidates aimed at activating the immune system against solid tumors.
The core of Replimune’s portfolio includes RP1, RP2, and RP3, all based on genetically-engineered strains of herpes simplex virus 1 (HSV-1). These strains are modified to maximize tumor killing and stimulate a systemic anti-tumor immune response. RP1, the company’s lead product, is designed for enhanced tumor killing and has shown promising results in combination with anti-PD1 therapies. It is currently undergoing clinical trials for anti-PD1 failed melanoma and other skin cancers, with plans to submit a Biologics License Application (BLA) in 2H 2024.
Another notable candidate is RP2, which expresses an anti-CTLA-4 antibody-like protein to further enhance immune response. RP2 has demonstrated durable response rates in advanced uveal melanoma patients, a particularly challenging cancer type with limited treatment options. RP3, the third candidate in the pipeline, is engineered to express multiple immune-activating proteins, though its development has currently been paused to focus on higher priority programs.
Replimune's recent achievements include favorable safety profiles and substantial response rates in clinical trials. For instance, RP2 in combination with nivolumab showed a durable overall response rate of nearly 30% in patients with metastatic uveal melanoma. Additionally, RP1 has demonstrated significant anti-tumor activity in organ transplant recipients who typically cannot undergo systemic immunotherapy.
The company has established alliances with major pharmaceutical entities, such as Regeneron Pharmaceuticals, to further its clinical trials and explore combination therapies. Financially, Replimune is robust, with a cash runway extending into early 2026, thanks to strategic reprioritization and successful capital management.
Replimune is dedicated to evolving its portfolio and optimizing its RPx platform. The dual local and systemic mechanism of action of its therapies offers a versatile approach that can be combined with various other cancer treatment modalities, thus holding significant promise for the future of oncology.
Replimune Group, a clinical-stage biotechnology company based in Woburn, MA, announced that CEO Philip Astley-Sparke will present at the SVB Securities Global Biopharma Conference on February 14, 2023, at 9:20 AM ET. This event will highlight Replimune's innovative work in developing tumor-directed oncolytic immunotherapies through its proprietary RPx platform. This platform, leveraging a potent HSV-1 backbone, aims to enhance anti-tumor immune response. A webcast of the presentation will be accessible on their website, with a replay available for 30 days post-event.
Replimune Group, Inc. (NASDAQ: REPL) announced the grant of inducement equity awards to Chris Sarchi, its new Chief Commercial Officer. These awards include non-qualified stock options to purchase 82,500 shares and restricted stock units for 55,000 shares. The options have an exercise price of $27.20, vesting over four years. The awards were approved under the Employment Commencement Incentive Plan and align with Nasdaq regulations. Replimune aims to transform cancer treatment through innovative oncolytic immunotherapies, utilizing its proprietary RPx platform.
Replimune Group, Inc. (NASDAQ: REPL) announced the appointment of Christopher Sarchi as Chief Commercial Officer and Sushil Patel, Ph.D., as Chief Strategy Officer, effective immediately. These leadership changes aim to enhance commercial planning ahead of the expected 2024 launch of RP1. Sarchi brings extensive oncology experience, including successful drug launches, while Patel will focus on global commercialization strategies. The company is pioneering oncolytic immunotherapies to transform cancer treatment.
Replimune Group, a clinical-stage biotechnology company focused on oncolytic immunotherapies, will have CEO Philip Astley-Sparke present at the 41st Annual J.P. Morgan Healthcare Conference on January 9, 2023, at 9:45 AM PT in San Francisco. The event will be broadcasted via webcast, available on their website, with a replay accessible for 30 days. Replimune's innovative RPx platform utilizes a robust HSV-1 backbone, aiming to enhance immune response against tumors, showcasing potential synergy with various cancer treatments.
BOSTON, Dec. 08, 2022 - Replimune Group, Inc. (Nasdaq: REPL) has announced the pricing of a public offering of 5,374,486 shares of common stock at $23.50 per share and pre-funded warrants for 4,200,000 shares at $23.4999 each. The total gross proceeds are expected to be approximately $225 million, before expenses. This offering is managed by J.P. Morgan and others, with a closing date of December 13, 2022, pending customary conditions. Replimune's innovative approach targets cancer treatment through its proprietary RPx platform, enhancing immunogenic responses and potentially interacting synergistically with existing therapies.
Boston, Dec. 07, 2022 - Replimune Group, Inc. (Nasdaq: REPL) has announced a proposed public offering of $125 million in common stock and pre-funded warrants. The offering includes an option for underwriters to buy an additional $18.75 million in shares. J.P. Morgan and SVB Securities are serving as joint book-running managers. This offering will follow a previously filed shelf registration statement. Adverse market conditions may impact the timing and completion of this offering.
Replimune Group announced promising results from the IGNYTE clinical trial of RP1 combined with nivolumab for anti-PD1 failed melanoma, showing an overall response rate (ORR) of 36% and a complete response (CR) rate of 20% among 75 patients. The trial demonstrated clinically meaningful activity, especially in advanced cases. Furthermore, safety data revealed a favorable profile with mostly mild side effects. Replimune aims to expand its cancer treatment franchise with RP1 and leverage collaborations to expedite development in various cancer types.
Replimune Group, Inc. (NASDAQ: REPL) has announced a collaboration with Roche to advance its RP2/3 program for treating colorectal cancer (CRC) and hepatocellular carcinoma (HCC). The agreement includes cost sharing for clinical trials, with Roche supplying its FDA-approved drugs, atezolizumab and bevacizumab. This collaboration aims to enhance treatment options for patients and is aligned with Replimune's strategy to partner with industry leaders. The Phase 2 clinical trials are set to begin in the first half of 2023, focusing on various cancers.
Replimune Group, a clinical-stage biotechnology company based in Woburn, MA, announced a fireside chat presentation at the Piper Sandler 34th Annual Healthcare Conference on December 1, 2022, at 1:00 PM ET. The company focuses on developing tumor-directed oncolytic immunotherapies utilizing its proprietary RPx platform, which employs a potent HSV-1 backbone. This platform aims to induce systemic anti-tumor responses by killing tumors and altering the tumor microenvironment. Replimune was founded in 2015 and is publicly traded on NASDAQ under the symbol REPL.
Replimune Group Inc. (NASDAQ: REPL) is set to host an investor event on December 7, 2022, at 8:00 AM ET to present preliminary data from the six-month follow-up of its IGNYTE clinical trial involving RP1 and Opdivo® for melanoma patients who failed anti-PD1 therapy. The event will also explore the commercial potential of RP1 in skin cancer and provide updates on the RP2 and RP3 programs. Live access to the event will be available on the company’s website, with a replay option thereafter.
FAQ
What is the current stock price of Replimune Group (REPL)?
What is the market cap of Replimune Group (REPL)?
What is Replimune Group, Inc.?
What is the Immulytic™ platform?
What are Replimune’s main product candidates?
What recent achievements has Replimune made?
What are the clinical goals for RP1?
How does RP2 differ from RP1?
What is the financial outlook for Replimune?
What partnerships does Replimune have?
What is the RPx platform?