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Arcus Biosciences, Inc. (NASDAQ: RCUS) is a cutting-edge, clinical-stage biopharmaceutical company dedicated to developing innovative immunotherapies for cancer treatment. Founded in 2015 by experienced researchers from the biotechnology and pharmaceutical sectors, Arcus is based in the San Francisco Bay Area, a hub for biotechnological innovation.
Arcus Biosciences focuses on leveraging insights in immunology to create new cancer therapeutics. The company is particularly known for its work on the ATP-adenosine pathway, a significant driver of immunosuppression in the tumor microenvironment. Their aim is to optimize small-molecule immuno-oncology product candidates that could revolutionize cancer treatment.
Arcus has a robust product pipeline that includes several promising candidates such as Domvanalimab, Etrumadenant, AB598, and Casdatifan. These drugs target different aspects of the immune system to either modulate cellular processes in cancer or directly combat tumor growth.
Significant achievements include successful clinical trials for treating various types of cancers, including lung, colorectal, and pancreatic cancers. The company operates through a single segment focused on the development and commercialization of its immunotherapies.
Arcus prides itself on maintaining an internal team of highly skilled professionals rather than outsourcing its research and development efforts. This approach ensures the highest quality and innovation in their drug discovery process.
With ongoing partnerships and collaborations, notably with Gilead Sciences, Arcus is well-positioned to bring its innovative therapies to market, providing new hope for patients with cancer.
Arcus Biosciences (NYSE:RCUS), a clinical-stage biopharmaceutical company focused on cancer therapies, has granted equity awards to six new employees. The Compensation Committee approved stock options to purchase 28,600 shares at $17.33 per share (the closing price on October 23, 2024) and restricted stock units for 14,300 shares. These awards were granted under the company's 2020 Inducement Plan, which was approved under NYSE Listed Company Manual Rule 303A.08's inducement exception.
Arcus Biosciences presented promising first clinical data for casdatifan, their HIF-2a inhibitor, in treating metastatic kidney cancer. The Phase 1/1b study (ARC-20) showed a 34% objective response rate (2 responses pending confirmation) and 25% confirmed response rate in the 100mg daily dose expansion cohort of 32 patients. The treatment demonstrated an 81% disease control rate with only 19% primary progression. Safety profile was manageable, with Grade 3 treatment-related adverse events at 42%, mainly including anemia (36%) and hypoxia (9%). The company plans to initiate PEAK-1, their first Phase 3 study, in the first half of 2025.
Arcus Biosciences (NYSE:RCUS), a clinical-stage, global biopharmaceutical company focusing on cancer therapies, has announced a conference call and webcast scheduled for November 6th, 2024, at 2 PM PT / 5 PM ET. The call will discuss the company's third-quarter 2024 financial results and provide a pipeline update for the quarter ended September 30th, 2024.
Investors can join the call by dialing +1 (404) 975-4839 (local) or +1 (833) 470-1428 (toll-free), using Access Code: 940081. Online registration is also available. A live webcast and slide presentation will be accessible through the "Investors & Media" section of the Arcus Biosciences website. A replay of the webcast will be made available after the event.
Arcus Biosciences (NYSE:RCUS), a clinical-stage global biopharmaceutical company focusing on cancer treatments, has announced new employment inducement grants. The Compensation Committee of the company's Board of Directors has granted four new employees options to purchase a total of 24,100 shares of common stock at an exercise price of $17.47 per share, which was the closing price on October 8, 2024. Additionally, these employees received restricted stock units to acquire a total of 12,050 shares of common stock.
These equity awards were granted under the company's 2020 Inducement Plan, which was approved by the Board of Directors in January 2020 in accordance with the "inducement exception" under NYSE Listed Company Manual Rule 303A.08.
Arcus Biosciences (NYSE:RCUS) will present first clinical data from the ARC-20 study at the 2024 EORTC-NCI-AACR Symposium. The oral presentation will highlight data from the 100mg daily monotherapy expansion cohort of ARC-20, a Phase 1/1b study evaluating casdatifan in late-line clear cell renal cell carcinoma (ccRCC). Data will include safety, efficacy, objective response rate, and rate of primary progression.
Arcus is pursuing a broad development program for casdatifan in ccRCC, including the planned initiation of their first Phase 3 study, PEAK-1, in the first half of 2025. The company will also present posters on casdatifan's preclinical evaluation, human pharmacokinetics/pharmacodynamics, and AB801, Arcus's AXL inhibitor.
A conference call to discuss the ARC-20 results will be held on October 24, 2024, at 5:00 AM PT / 8:00 AM ET.
Arcus Biosciences (NYSE:RCUS) has announced a clinical trial collaboration agreement with AstraZeneca to evaluate casdatifan (AB521), Arcus's investigational HIF-2a inhibitor, in combination with volrustomig, AstraZeneca's investigational PD-1/CTLA-4 bispecific antibody, in patients with clear cell renal cell carcinoma (ccRCC). This marks the second clinical collaboration between the two companies.
The study, sponsored and operationalized by AstraZeneca, aims to assess the safety and early efficacy of the combination therapy in advanced ccRCC patients. Arcus believes casdatifan has best-in-class potential based on observed PK and PD profiles and emerging clinical data from their ARC-20 study. The collaboration seeks to improve outcomes for ccRCC patients by combining HIF-2a inhibition with volrustomig.
Under the Gilead and Arcus collaboration agreement, Gilead retains the right to opt-in to development and commercialization for casdatifan after Arcus delivers a qualifying data package.
Arcus Biosciences (NYSE:RCUS), a clinical-stage global biopharmaceutical company focused on developing differentiated molecules and combination therapies for cancer, has announced new employment inducement grants. The Compensation Committee of the Company's Board of Directors has granted five new employees options to purchase 38,600 shares of the Company's common stock at an exercise price of $15.71 per share, which was the closing price on September 23, 2024. Additionally, restricted stock units to acquire 19,300 shares of the Company's common stock were granted. These equity awards were granted under the Company's 2020 Inducement Plan, approved by the Board of Directors in January 2020 pursuant to the "inducement exception" under NYSE Listed Company Manual Rule 303A.08.
Arcus Biosciences (NYSE:RCUS), a clinical-stage biopharmaceutical company focused on cancer therapies, has announced new employment inducement grants. The Compensation Committee of the company's Board of Directors has awarded four new employees with:
- Options to purchase a total of 27,800 shares of common stock at an exercise price of $16.31 per share
- Restricted stock units to acquire a total of 13,900 shares of common stock
These equity awards were granted under Arcus Biosciences' 2020 Inducement Plan, approved by the Board in January 2020 under the NYSE Listed Company Manual Rule 303A.08 'inducement exception'.
Arcus Biosciences (NYSE:RCUS) has secured a $250 million term loan facility from Hercules Capital, enhancing its financial position and operational flexibility. The facility includes $150 million committed, with $50 million drawn at closing and $100 million available at Arcus's discretion. This non-dilutive funding will support the recently announced Phase 3 PEAK-1 study for casdatifan, Arcus's HIF-2a inhibitor for clear cell renal cell carcinoma (ccRCC). The loan matures in five years, extendable to six, with an interest-only period of four years, extendable to five based on regulatory milestones. This financial boost allows Arcus to accelerate its development program for casdatifan across multiple ccRCC settings.
Arcus Biosciences (NYSE:RCUS), a clinical-stage biopharmaceutical company focusing on cancer therapies, has announced new employment inducement grants. The Compensation Committee of the company's Board of Directors has granted three new employees options to purchase 21,100 shares of common stock at an exercise price of $18.01 per share, which was the closing price on August 23, 2024. Additionally, restricted stock units to acquire 10,550 shares of common stock were granted. These equity awards were issued under the company's 2020 Inducement Plan, approved by the Board in January 2020 under the 'inducement exception' of NYSE Listed Company Manual Rule 303A.08.
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