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Pulmatrix - PULM STOCK NEWS

Welcome to our dedicated page for Pulmatrix news (Ticker: PULM), a resource for investors and traders seeking the latest updates and insights on Pulmatrix stock.

Overview

Pulmatrix Inc (PULM) is a clinical-stage biotechnology company dedicated to transforming the field of inhaled therapeutics. With a strong foundation in advanced drug delivery sciences, Pulmatrix is focused on the discovery and development of novel inhaled therapeutic products designed to address critical respiratory and central nervous system disorders that present significant unmet medical needs. The company has positioned itself at the intersection of pharmaceutical science and cutting-edge particle engineering, making its innovations highly relevant to both healthcare providers and investors seeking scientifically validated approaches to disease management.

Innovative iSPERSE Technology

The heart of Pulmatrix's innovation lies in its patented dry powder technology, iSPERSE, which stands for "inhaled Small Particles Easily Respirable and Emitted." This technology represents a paradigm shift in inhalation therapy by producing particles that are purposely engineered to be small, dense, and exceptionally dispersible. Such properties enable efficient delivery of drugs deep into the lungs while maximizing local concentrations and minimizing systemic side effects. The inherent versatility of the iSPERSE platform allows it to be integrated with various dry powder inhaler devices, thereby accommodating a broad spectrum of drug substances ranging from small molecule compounds to peptides, proteins, and nucleic acids.

Therapeutic Product Pipeline

Pulmatrix’s pipeline is strategically designed to target diseases where inhalation delivery can yield clinically significant benefits. Focusing on both respiratory conditions, such as chronic obstructive pulmonary disease (COPD) and other pulmonary infections, as well as central nervous system disorders including acute migraine, the company is exploring clinical applications where improved local drug delivery results in enhanced therapeutic outcomes. By emphasizing localized treatment, Pulmatrix aims to deliver medications that work more efficiently at the site of disease action while potentially mitigating overall systemic exposure, which is a distinct advantage over traditional routes of administration.

Business Model and Market Position

Operating as a clinical-stage biopharmaceutical entity, Pulmatrix’s strategy revolves around the discovery, development, and eventual commercialization of its innovative inhaled products. The company derives its value from a combination of advancing clinical programs and leveraging strategic partnerships and licensing agreements. Its emphasis on technological innovation and solid scientific methodology positions it uniquely among its peers in the biotechnology sector. Pulmatrix differentiates itself by focusing on a specialized drug delivery platform that challenges the limitations of conventional aerosol and nebulized therapies, thereby offering a competitive alternative in high-need therapeutic areas.

Industry and Regulatory Context

In the highly regulated realm of biotechnology, compliance with stringent safety and quality standards is paramount. Pulmatrix operates under rigorous regulatory oversight, ensuring its clinical trials meet evolving guidelines for safety, efficacy, and quality control. The company’s methodical approach to clinical testing, which includes detailed assessments of pharmacokinetics, tolerability, and dose optimization, exemplifies its commitment to precision and responsibility in the development of novel therapeutics. This regulatory focus not only reinforces confidence in its scientific output but also contributes to the overall trust placed in its advanced drug delivery solutions.

Collaborations and Strategic Partnerships

Pulmatrix has established a network of strategic alliances that bolster its clinical programs and technological capabilities. Through licensing agreements and collaborative transactions with other leading companies in the industry, Pulmatrix is able to enhance the commercialization potential of its iSPERSE platform. Such partnerships facilitate access to complementary technologies and market channels, thereby strengthening the company’s position within the competitive landscape of inhaled therapeutics. These collaborative efforts provide financial flexibility and strategic insight, ensuring that Pulmatrix remains agile and capable of adapting to evolving market dynamics.

Clinical Development Focus

The company’s clinical development programs are designed with rigorous scientific scrutiny to ensure that every product candidate is backed by robust clinical data. Pulmatrix’s trials focus on assessing quickly acting treatments with optimized safety profiles—a critical consideration for acute conditions such as migraine and chronic pulmonary disorders. The emphasis on detailed pharmacodynamic and pharmacokinetic evaluations is reflective of its commitment to evidence-based medicine and comprehensive patient care. By systematically refining dosage and delivery methodologies, Pulmatrix lays a strong foundation for future clinical success and enhanced patient outcomes.

Commitment to Advancing Patient Care

Beyond technological innovation, Pulmatrix is driven by a commitment to improving patient care on a fundamental level. The targeted delivery approach facilitated by its iSPERSE platform is designed to achieve higher local drug concentrations, which can result in more effective treatment outcomes with reduced systemic side effects. This patient-centric strategy not only addresses unmet therapeutic needs in respiratory and CNS disorders but also underscores the company’s broader mission of leveraging advanced science to improve quality of life. The holistic integration of research, technology, and clinical insight exemplifies Pulmatrix’s dedication to advancing healthcare standards through smart and efficient drug delivery mechanisms.

Rhea-AI Summary

Pulmatrix (PULM) announced its Q4 and full-year 2024 financial results, highlighting its planned merger with Cullgen expected to close in H1 2025. The company reported revenues of $7.8 million for 2024, up from $7.3 million in 2023. Research and development expenses decreased to $7.2 million from $15.5 million, while general and administrative expenses increased to $7.8 million from $6.5 million.

As part of the merger strategy, Pulmatrix plans to divest its clinical assets, including the Phase 2-ready PUR3100 for acute migraine, PUR1800 for AECOPD, and PUR1900 antifungal treatment. The company's cash position stands at $9.5 million as of December 31, 2024, deemed sufficient until the merger completion.

The company's iSPERSE™ technology portfolio includes 149 granted patents, with 19 U.S. patents expiring between 2024 and 2037, plus approximately 50 pending applications.

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Pulmatrix (NASDAQ: PULM) announced a merger agreement with privately-held Cullgen, creating a Nasdaq-listed company focused on targeted protein degradation technology. The combined entity will have approximately $65 million in cash, providing funding through multiple clinical milestones and runway through 2026. The merger includes three degrader programs approaching or in Phase 1 clinical trials - two for cancer treatment and one for acute and chronic pain. As part of the agreement, Pulmatrix will divest its assets, including PUR3100 for acute migraine and other iSPERSE™ technology-based candidates. Cullgen brings its proprietary uSMITE™ platform for developing targeted protein degraders and degrader-antibody conjugates (DACs).

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Pulmatrix (PULM) reported Q3 2024 financial results with revenues decreasing to $0.4M from $1.8M in Q3 2023. Research and development expenses decreased to $0.8M from $4.0M, while general and administrative expenses increased to $2.2M from $1.7M. The company's cash position of $10.8M is projected to fund operations into Q4 2026. Key developments include completing PUR1900 wind down activities, closing transactions with MannKind for iSPERSE™ technology licensing, and pursuing strategic alternatives for PUR3100, their acute migraine treatment candidate which is Phase 2-ready.

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Pulmatrix (NASDAQ: PULM) announced Q2 2024 financial results and corporate updates. Key highlights include:

  • $12.4 million in cash and cash equivalents, with an additional $1.4 million in restricted cash becoming unrestricted in August 2024
  • Projected cash runway extended into Q4 2026
  • Completed transactions with MannKind , validating iSPERSE™ technology
  • Pursuing strategic alternatives for PUR3100 and iSPERSE™ technology
  • Revenues decreased to $1.6 million in Q2 2024 from $1.8 million in Q2 2023
  • R&D expenses decreased to $2.8 million from $4.2 million year-over-year
  • Net loss of $5.8 million in Q2 2024 compared to $3.8 million in Q2 2023

The company is focusing on cost-saving measures and exploring partnerships for its clinical assets.

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Pulmatrix announced a series of transactions with MannKind involving a cross-license agreement and transfer of laboratory assets. Pulmatrix's iSPERSE™ technology will be licensed to MannKind, while Pulmatrix gains access to MannKind's Cricket® inhalation device for its PUR3100 formulation, aimed at treating acute migraine. Additionally, MannKind will assume Pulmatrix's lease for its Bedford, Mass. R&D facility, extending Pulmatrix's cash runway into 2026. The agreement, expected to close in July 2024, also includes a master service arrangement for MannKind to provide future dry powder drug formulation services to Pulmatrix.

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Pulmatrix announced the publication of clinical results for its orally inhaled DHE (PUR3100) for acute migraine in the peer-reviewed journal Headache: The Journal of Head and Face Pain. The Phase 1 study showed that PUR3100 has rapid systemic pharmacokinetics (PK) similar to intravenous (IV) DHE, with a mean time to maximum concentration (Tmax) of 5 minutes and a mean concentration (Cmax) in the therapeutic window for all doses tested.

Compared to IV DHE, PUR3100 demonstrated improved safety and tolerability, with lower incidences of nausea, vomiting, and headache. Pulmatrix received FDA acceptance for an Investigational New Drug (IND) application for a Phase 2 study, and the company is exploring options to advance PUR3100 into Phase 2 trials.

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Pulmatrix, Inc. reported $16.3 million cash, with a cash runway into Q1 2026. The partnership amendment with Cipla led to the halt of PUR1900 Phase 2b study, reducing cash burn. Cipla will now develop PUR1900 outside the US. Revenue increased to $5.9 million, net income rose to $0.8 million, and R&D expenses decreased. PUR3100 is Phase 2-ready, while PUR1800 showed positive results for AECOPD treatment.

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Pulmatrix, Inc. reported $19.2 million in cash and cash equivalents at the end of 2023, ensuring cash runway until Q1 2026. The 3rd amendment to the Cipla partnership led to the cessation of the PUR1900 Phase 2b study, reducing cash burn. Cipla will now independently develop PUR1900, focusing on high-demand markets, with Pulmatrix receiving a 2% royalty on net sales.
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Pulmatrix, Inc. (PULM) announces a further amendment to its agreement with Cipla for the development of PUR1900, refocusing on markets with the greatest unmet need and a faster path to approval. Cipla will take sole responsibility for the development of PUR1900, while Pulmatrix will significantly reduce cash burn and focus on strategic alternatives. Pulmatrix will receive 2% royalties on net sales of Pulmazole in the Cipla Territory.
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Pulmatrix, Inc. (PULM) reports Q3 2023 results, with $21.3 million in cash and cash equivalents providing projected cash runway into Q1 2025. Phase 2b study of PUR1900 ongoing with 17 active sites in four countries, topline data expected in H2 2024. Received 'study may proceed' letter for Phase 2 study of PUR3100 for acute migraine.
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FAQ

What is the current stock price of Pulmatrix (PULM)?

The current stock price of Pulmatrix (PULM) is $6.06 as of April 2, 2025.

What is the market cap of Pulmatrix (PULM)?

The market cap of Pulmatrix (PULM) is approximately 22.4M.

What is Pulmatrix's primary business focus?

Pulmatrix develops novel inhaled therapeutic products using its proprietary iSPERSE technology to address respiratory and CNS disorders with significant unmet medical needs.

How does the iSPERSE technology work?

The technology produces small, dense, and dispersible particles that enable efficient deep lung delivery, enhancing local therapeutic concentrations while reducing systemic exposure.

What types of drug substances can be delivered using this platform?

The platform is versatile and can accommodate small molecules, peptides, proteins, and nucleic acids, making it relevant for a wide array of therapeutic applications.

How does Pulmatrix differentiate itself from traditional inhalation therapies?

Its advanced particle engineering creates highly efficient drug delivery systems that ensure superior deposition in the lungs compared to conventional aerosolized therapies.

Which therapeutic areas does Pulmatrix target?

The company focuses on respiratory diseases, like COPD and pulmonary infections, as well as central nervous system disorders such as acute migraine.

What role do strategic partnerships play in Pulmatrix's business model?

Partnerships and licensing agreements enhance the commercialization potential of its iSPERSE platform, providing financial flexibility and market access to support its clinical programs.

How does Pulmatrix ensure compliance with industry regulations?

The company rigorously adheres to clinical safety protocols and quality control standards, engaging regularly with regulatory agencies to ensure its trials meet all necessary guidelines.

What sets Pulmatrix apart in the competitive biopharmaceutical landscape?

Its unique focus on engineered dry powder technology and targeted inhalation delivery offers a distinct competitive edge by addressing challenges inherent in traditional drug delivery methods.
Pulmatrix

Nasdaq:PULM

PULM Rankings

PULM Stock Data

22.44M
3.63M
0.65%
9.01%
0.95%
Biotechnology
Pharmaceutical Preparations
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United States
FRAMINGHAM